Mortality of Post-COVID-19 Condition: 2025 Update

COVID, Journal Year: 2025, Volume and Issue: 5(1), P. 11 - 11

Published: Jan. 14, 2025

Background: The coronavirus disease 2019 (COVID-19) pandemic has generated profound health, societal, and economic consequences, which have been further compounded by long-term sequelae commonly referred to as post-COVID-19 or long-COVID syndrome. Understanding the real-world impact of mortality is therefore critical for effective healthcare planning resource allocation. Methods: A descriptive epidemiological study was conducted using data from US National Center Health Statistics identify deaths attributed condition, classified ICD-10 code U09.9, October 2021 December 2024. Demographic factors such gender, age, place death were also extracted. Results: By 2024, 2653 under corresponding an age-adjusted rate 0.089 × 100,000. Mortality significantly higher in males compared females (0.098 vs. 0.081 100,000; p < 0.001). clear age-related gradient observed, with rates increasing almost linearly advancing age. largest fraction occurred at home (33.0%), followed nursing homes (26.3%) medical facilities (24.1%). Conclusions: These findings highlight substantial yet complex condition on mortality, observed males, older adults, individuals home, highlighting need targeted interventions allocation, particularly these higher-risk groups.

Language: Английский

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Epidemiology and Predisposing Factors of Post-COVID Venous Thrombosis: A Concise Review

Seminars in Thrombosis and Hemostasis, Journal Year: 2023, Volume and Issue: 50(02), P. 271 - 274

Published: June 16, 2023

Abstract Long-coronavirus disease 2019 (COVID-19) represents a heterogeneous clinical syndrome characterized by pathologic continuum of signs, symptoms, and also laboratory/radiologic abnormalities that may persist for long time after recovering from an acute severe respiratory syndrome-coronavirus 2 infection. Among the various components this postviral condition, risk venous thromboembolism in patients hospitalized COVID-19 remains considerably higher discharge, especially older individuals, men, with longer hospital stays more aggressive treatment (e.g., mechanical ventilation and/or intensive care), when thromboprophylaxis is not used, those persistent prothrombotic state. Patients who have these predisposing factors should be monitored closely to intercept any thrombosis occur post-COVID time-related manner but benefit extended antiplatelet therapy.

Language: Английский

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Long COVID management: a mini review of current recommendations and underutilized modalities

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: June 14, 2024

Long COVID is a condition that develops in subset of patients after COVID-19 infection comprising symptoms varying severity encompassing multiple organ systems. Currently, long without consensus on formal definition, identifiable biomarkers, and validated treatment. expected to be long-term chronic for associated with suffering incapacity. There an urgent need clear management guidelines the primary care provider, who essential bridging gap more specialized improve quality life functionality their living COVID. The purpose this mini review provide providers latest highlights from existing literature regarding most common current recommendations. This also underutilized interventions stellate ganglion blocks low-dose naltrexone, both well-established safety profiles demonstrated some COVID, encourages prompt referral interventional pain management.

Language: Английский

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Post-infective myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID as two puzzling faces of the same medal. Recent insights.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 114365 - 114365

Published: March 1, 2025

Language: Английский

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Multi-layered deep immune profiling, SARS-CoV-2 RNAemia and inflammation in unvaccinated COVID-19 individuals with persistent symptoms

Communications Medicine, Journal Year: 2025, Volume and Issue: 5(1)

Published: May 5, 2025

Long-COVID immunopathogenesis involves diverse factors. We longitudinally characterize hospitalized COVID-19 patients, examining the role of SARS-CoV-2 RNAemia and inflammation in immune dysregulation. Hospitalized patients are evaluated during acute infection (T0), 3 months post-symptom onset (T1), years if symptoms persisted (T2). Immune profile includes characterization SARS-CoV-2-specific/non-specific T/B cells (flow cytometry) antibodies (ELISA, neutralization, ADCC). cytokines quantified (RT-PCR, cytometric beads array) correlated. non-parametric cross-sectional, longitudinal correlation analyses. Here we show 48 individuals COVID-19, 38 exhibit early persistent (EPS+) post-symptoms onset, 10 do not (EPS-). Groups comparable for age, sex, co-morbidities. The EPS+ shows fatigue, dyspnoea, anosmia/dysgeusia, diarrhea, chronic pain, mnestic disorders. Over time, they a reduction neutralization ability total SARS-CoV-2-specific CD4 T cells, with increased TEMRA, failure to increase RBD-specific B IgA+ MBCs. higher levels T0-IFN-γ + T1-IL-2 TEM T1-TNF-α cTfh. In EPS+, baseline positively correlates follow-up ADCC. Among at T1, 33 after infection, 5 lost follow-up. 10/33 long-term (late symptoms, EPS LPS+), whereas 23/33 fully recover (EPS LPS-). Antibodies, RNAemia, no differences between/within groups any time point. Early associated multi-layered SARS-CoV-2-specific/non-SARS-CoV-2-specific shift towards non-Ag-specific TEMRA ADCC trigger may relate RNAemia. dysregulation does associate symptoms. Further research on is needed.

Language: Английский

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Physical Activity, Long-COVID, and Inactivity: A Detrimental Endless Loop

Journal of Physical Activity and Health, Journal Year: 2024, Volume and Issue: 21(5), P. 420 - 422

Published: March 11, 2024

The risk of developing medium- and long-term sequelae after recovery from COVID-19 is validated. Long-COVID burden represents a major health care issue, thus paving the way to effective prevention and/or treatment measures. Physical activity prevents many human pathologies, including COVID-19. Being physically active before immediately severe acute respiratory syndrome coronavirus 2 infection substantially lowers long-COVID. In addition, long-COVID an important cause physical inactivity. Physically inactive individuals are at increased long-COVID, while patients with more likely reduce their levels recovering infection, generating continuous loop. This harmful interaction needs be recognized by public institutions, adoption as routine clinical practice in all proactively promoted.

Language: Английский

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Long COVID: An Epidemic within the Pandemic

COVID, Journal Year: 2023, Volume and Issue: 3(5), P. 773 - 776

Published: May 19, 2023

Coronavirus disease 2019 (COVID-19), a life-threatening infectious caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in the Chinese city of Wuhan late and has subsequently spread worldwide, reaching pandemic proportions [...]

Language: Английский

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Envisioning Mobile Telemanipulator Robots for Long Covid

Published: March 11, 2024

Long Covid (LC) is a debilitating disease impacting over 65 million people worldwide. The heterogeneity, severity, and unpredictability of LC symptoms cause episodic disability, leading to widespread social isolation among People with (PwLC). Mobile Telemanipulator Robots (MTRs) offer the potential support inclusion PwLC. However, nuanced MTR design needed accommodate PwLC's fluctuating needs avoid perpetuating stigma. In this work, we engaged PwLC in participatory process explore how MTRs can be designed them. We present considerations, grounded lenses critical disability studies access studies, for accessible systems plan expand on develop new shared control algorithms ethical implications autonomous behaviors such systems.

Language: Английский

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Piecing together the narrative of #longcovid: an unsupervised deep learning of 1,354,889 X (formerly Twitter) posts from 2020 to 2023

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 16, 2024

To characterize the public conversations around long COVID, as expressed through X (formerly Twitter) posts from May 2020 to April 2023.

Language: Английский

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Physiotherapy interventions in post- and long-COVID-19: a scoping review protocol

BMJ Open, Journal Year: 2024, Volume and Issue: 14(8), P. e077420 - e077420

Published: Aug. 1, 2024

Introduction Post- or long-COVID-19 conditions manifest with a spectrum of symptoms reminiscent pulmonary, musculoskeletal, psychological and neurological disorders. Individuals post- syndrome often present myalgia, pulmonary problems fatigue, which significantly impact their daily functioning. Physiotherapy interventions are an accepted medical remedy for these symptoms. This scoping review aims to outline the evidence physiotherapy documented in scientific literature, specifically focusing on hands-on therapy. Methods analysis conforms methodological framework established by Joanna Briggs Institute (JBI). The procedure drafting involves several steps, starting defining research question inclusion exclusion criteria. Eligible studies those analysing treatment parameters direct patient interaction patients. Telemedicine entirely home-based workouts will be excluded aligning context outpatient Germany. literature search conducted PubMed, EBSCO research, Scopus, Web Science, Embase, PEDRO, Cochrane WISO databases two independent researchers. Screening, data extraction critical appraisal performed researchers using assessment tools provided JBI. Extracted encompass demographic characteristics, definitions conditions, descriptions interventions, outcome. Subsequently, findings disseminated through article conference presentation. Ethics dissemination Given that this does not involve human participants, ethical committee approval is deemed unnecessary. results published peer-reviewed journals presented at academic physiotherapeutic conferences.

Language: Английский

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