Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2024, Volume and Issue: 62(11), P. 2091 - 2093
Published: Sept. 2, 2024
Language: Английский
Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(4), P. 134 - 134
Published: March 30, 2025
Biopsychosocial factors, including family history, influence the development of breast cancer. Malignancies in women with a history cancer may be detectable based on DNA methylation and microRNA. Objectives: The present study extended an integrative analysis microRNA to identify genes associated biopsychosocial factors. Methods: We identified 3060 healthy from Taiwan Biobank included 32 blood plasma samples for factors epigenetic changes. GEO databases bioinformatics approaches were used identification validation potential genes. Results: Our revealed GNPDA1 SLC25A16 as Age, cancer, alcohol consumption current data set set. exhibited significant expression tissues UALCAN analysis, where they overexpressed underexpressed, respectively. Through MethSurv hypomethylation hypermethylation poor prognoses terms overall survival Moreover, through MetaCore functional enrichment BRCA1, BRCA2, pro-oncogenic actions androgen receptor Further, enriched known targets approved drugs Conclusions: These two might serve biomarkers early detection especially
Language: Английский
Citations
0
IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 189224 - 189224
Published: Nov. 1, 2024
Language: Английский
Citations
3
Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 30(4)
Published: Aug. 9, 2024
Tamoxifen is a widely used anti‑estrogen drug in the endocrine therapy of breast cancer (BC). It blocks estrogen signaling by competitively binding to receptor α (ERα), thereby inhibiting growth BC cells. However, with long‑term application tamoxifen, subset patients have shown resistance which leads low overall survival and progression‑free survival. The molecular mechanism mainly due downregulation ERα expression abnormal activation PI3K/AKT/mTOR pathway. Moreover, targeted gene mediated DNA methylation an important regulatory mode control protein expression. In present review, tamoxifen are briefly introduced, followed focus on effect sensitivity. Finally, clinical for described, including its use as prognostic indicator. it hypothesized that when combination could recover tamoxifen.
Language: Английский
Citations
2
ACS Omega, Journal Year: 2024, Volume and Issue: 9(42), P. 43034 - 43045
Published: Oct. 10, 2024
Uveal Melanoma (UM), a highly aggressive and metastatic intraocular cancer with strong propensity for liver metastasis, presents limited therapeutic alternatives unfavorable survival outcomes. Despite its low incidence, the underlying mechanisms of UM pathogenesis precise role mitochondrial metabolism in remain inadequately understood. Utilizing Cox proportional hazards regression analysis was used to assess prognostic relevance, consensus clustering employed molecular subtyping. A risk signature constructed using Least Absolute Shrinkage Selection Operator (LASSO) regression. We further conducted comparative analyses on clinicopathological characteristics, somatic mutation profiles, drug sensitivity, gene expression patterns, tumor microenvironment features across different subtypes. Moreover, nomogram developed evaluated. Among 1234 mitochondria metabolism-related genes (MMRGs), 343 were identified as significantly associated prognosis UM. These prognosis-associated MMRGs facilitated classification into two distinct subtypes, which displayed notable differences pathological staging. Furthermore, an index termed MMRGs-derived (MMI) derived from eight MMRGs, serving quantitative measure poor MMI demonstrated significant associations mutations, responsiveness, microenvironment, where higher levels corresponded worse prognosis, advanced stages, increased immune cell infiltration. The built upon provided potential tool clinical assessment patients. This study value predicting stratification within UM; however, additional basic research is warranted validate their applicability elucidate related mechanisms.
Language: Английский
Citations
1
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 26, 2024
Abstract Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer and characterized by significant molecular heterogeneity poor prognosis, primarily due to late-stage diagnoses. Therefore, detailed characterization LUAD crucial for developing biomarkers accurately detect disease in its early stages. This study investigates role DNA methylation LUAD, emphasizing potential as a biomarker detection tool understanding tumor biology. The identified 4,925 differentially methylated sites (DMSs) prioritized top 200 DMSs downstream analyses. Functional enrichment analysis revealed that site-specific hypermethylation exon 1 distal promoter regions are linked critical developmental processes, including morphogenesis, pattern specification, stem cell differentiation, synaptic transmission, suggesting these epigenetic changes may disrupt normal cellular functions contribute tumorigenesis. Support vector machines demonstrated diagnostic hypermethylated sites, achieving perfect classification adjacent tissues with few five features. Additionally, strong correlation between levels feature importance scores further explained predictive accuracy markers. also distinct subgroups within tumors, independent traditional staging, each associated unique transcriptional dysregulation biological such repair, immune response, ribosome biogenesis. These findings not only enhance our pathophysiology but underscore clinical utility guide patient management.
Language: Английский
Citations
0
Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2024, Volume and Issue: 62(11), P. 2091 - 2093
Published: Sept. 2, 2024
Language: Английский
Citations
0