C-Reactive Protein Levels and Risk of Cardiovascular Diseases: A Two-Sample Bidirectional Mendelian Randomization Study

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9129 - 9129

Published: May 23, 2023

Elevated C-reactive protein (CRP) levels are an indicator of inflammation, a major risk factor for cardiovascular disease (CVD). However, this potential association in observational studies remains inconclusive. We performed two-sample bidirectional Mendelian randomization (MR) study using publicly available GWAS summary statistics to evaluate the relationship between CRP and CVD. Instrumental variables (IVs) were carefully selected, multiple approaches used make robust conclusions. Horizontal pleiotropy heterogeneity evaluated MR-Egger intercept Cochran’s Q-test. The strength IVs was determined F-statistics. causal effect on hypertensive heart (HHD) statistically significant, but we did not observe significant myocardial infarction, coronary artery disease, failure, or atherosclerosis. Our primary analyses, after performing outlier correction MR-PRESSO Multivariable MR method, revealed that increased also HHD risk. excluding identified PhenoScanner, initial results altered, sensitivity analyses remained congruent with from analyses. found no evidence reverse causation CVD CRP. findings warrant updated confirm role as clinical biomarker HHD.

Language: Английский

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Hypertension among persons living with HIV/AIDS and its association with HIV-related health factors

AIDS Research and Therapy, Journal Year: 2024, Volume and Issue: 21(1)

Published: Jan. 11, 2024

Abstract Background Human Immunodeficiency Virus ( HIV) infection remains a public health concern in many countries. The increased life expectancy the post-Antiretroviral Therapy (ART) era has led to an risk of cardiovascular disease and death among Persons Living with HIV (PLHIV). Hypertension significant factor for PLHIV. Some studies have suggested associations between hypertension PLHIV HIV-related factors. Objective To determine prevalence on antiretroviral medications examine its association Methods A cross-sectional study was conducted attendants at adult clinic. 362 participants were selected by systematic sampling. Data diagnosis, factors, sociodemographic other traditional factors collected using standardized questionnaire patient chart review. Multivariate logistic regression model used adjusting hypertension. Results mean age 47.9 years majority female (77.1%). 42% had been > 10 years. 17.4%. Age 50 associated higher odds (aOR: 3.75, 95%CI 1.68, 8.55, p-value: 0.002). BMI overweight obese categories, history comorbid medical conditions (diabetes, hyperlipidemia) also 3. 76, 1.44, 9.81, 0.007), 3.17, 1.21, 8.32, 0.019) 14.25, 7.41, 27.41, < 0.001) respectively. No Conclusion common condition medications. Traditional years, BMI, conditions.

Language: Английский

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Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 26, 2025

This study aimed to investigate the interactions between Dietary approaches stop hypertension (DASH) and rs1501299 rs6450176 SNPs in terms of cardiometabolic risk factors. cross-sectional was conducted on 387 adults (20–70 years old) residing Yazd, Iran. The participants were selected from recruitment phase Yazd Health Study (YaHS) which is a population-based cohort 9,962 adults. genotypes determined using restriction fragment length polymorphism (RFLP) method. Unlike for G allele carriers rs1501299, high adherence DASH dietary pattern related lower diastolic blood pressure (DBP; P-interaction = 0.014) systolic (SBP; 0.051) with TT genotype. Moreover, individuals AA genotype SNP, this diet associated SBP (P-interaction 0.012), waist-to-hip ratio (WHR; 0.026) waist-to-height (WHtR; 0.040), while carriers, mean these items greater diet. results suggest that following may be central obesity indices only rs6450176, respectively, whereas it can higher WHR WHtR rs6450176.

Language: Английский

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Association of lipid accumulation products, or cardiometabolic index with asymptomatic intracranial arterial stenosis: a population-based study in Shandong, China

Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 108273 - 108273

Published: March 1, 2025

This study aimed to investigate the association of novel obesity indicators (lipid accumulation product [LAP] and cardiometabolic index [CMI]) with asymptomatic intracranial arterial stenosis (aICAS), particularly in different statuses. The included 1,994 participants (aged ≥ 40 years) from Rose Asymptomatic Intracranial Artery Stenosis (RICAS) study, free stroke or transient ischemic attack. Participants aICAS were screened using transcranial Doppler ultrasound diagnosed via magnetic resonance angiography. Multivariate logistic regression receiver operating characteristic (ROC) curves used explore LAP CMI aICAS. A total 146 Higher levels associated aICAS, moderate-to-severe Notably, was significantly (OR 1.58; 95% CI, 1.00-2.49; P = 0.048), showed highest area under curve (AUC, 0.654) among three (LAP, CMI, BMI) underweight normal-weight (Body mass [BMI] ≤23.9 kg/m²). In population (BMI ≥28.0kg/m2), 1.40; 1.11-1.77; 0.005), AUC (0.610). found a positive between elevated Furthermore, correlated normal weight individuals, while individuals. Our findings may provide additional risk stratification information for

Language: Английский

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Identification of Novel Therapeutic Targets for Hypertension

Hypertension, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

BACKGROUND: Persistently high blood pressure remains the leading risk factor for mortality worldwide. This study aims to identify potential drug targets hypertension. METHODS: Mendelian randomization was used therapeutic Genome-wide association summary statistics were obtained from UK Biobank and FinnGen study. Cis-expression quantitative trait loci eQTLGen Consortium served as genetic instruments. Colocalization analysis evaluated likelihood of shared causal variants between single-nucleotide polymorphisms influencing hypertension gene expression. Survival data assessed risks across participants with different alleles. RESULTS: identified 190 in discovery cohort 65 replication after multiple testing correction. 14 hypertension-related targets, including angiotensin-converting enzyme, AIMP1, CDC25A, EHMT2, FES, GPX1, GRK4, HSD3B7, NEK4, PTPN12, SIK2, SLC22A4, SLC2A4, TNFSF12. revealed individuals A allele at rs4308 enzyme had a higher incidence hypertension, while those T rs11242109 SLC22A4 showed lower hypertension-specific rate. CONCLUSIONS: Drug target studies offer new directions treatment, providing insights into its mechanisms robust developing antihypertensive drugs.

Language: Английский

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Elevated Waist-to-Height Ratio Increases the Risk of Cardiovascular and Cerebrovascular Disease Mortality in Elderly Type 2 Diabetes Mellitus Populations

Journal of Multidisciplinary Healthcare, Journal Year: 2025, Volume and Issue: Volume 18, P. 2681 - 2692

Published: May 1, 2025

To investigate the association between anthropometric indicators and cardiovascular cerebrovascular disease (CCVD) mortality risk in elderly patients with type 2 diabetes mellitus (T2DM). This retrospective cohort study included 897 T2DM who received long-term follow-up from January 2017 to 2020. Baseline data demographics, medical history, such as body mass index (BMI), waist circumference (WC), hip (HC), waist-to-hip ratio (WHR), waist-to-height (WHtR). The primary outcome was CCVD-related mortality. A Cox proportional hazards model used analyze associations physical measurements CCVD risk. During a mean of 7.13 ± 2.45 years, 45 deaths occurred, rate 70.37 per 10,000 person-years. regression analysis showed that higher WHtR significantly associated increased overall population. Subgroup analyses revealed elevated WHR predicted males, while BMI were greater females. Among without dyslipidemia or hyperuricemia, also indicated Elevated is an independent predictor patients. males females are important factors. Monitoring managing abdominal obesity may help reduce this

Language: Английский

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Higher cortisol level and reduced circulating triiodothyronine in patients with cardiovascular diseases: A case-control study

JRSM Cardiovascular Disease, Journal Year: 2025, Volume and Issue: 14

Published: April 1, 2025

Thyroid hormone plays a key role in cardiovascular diseases (CVDs), and stress may impact this relationship by affecting cortisol triiodothyronine (T3) levels. This study explored the association between stress, indicated levels, thyroid function patients, particularly those with hypertension. A cohort of 87 patients (37 females, 50 males) 60 healthy controls (28 32 was analyzed. Patients included coronary artery disease, acute myocardial infarction, high proportion anterior wall infarction (AWMI, 52%). Anthropometric data blood samples were collected, T3 levels measured using radioimmunoassay method. Blood pressure measurements also recorded to assess associations cortisol, function, Cardiovascular had significantly higher (1065.99 ± 700.54 ng/mL vs 768.35 563.10 ng/mL, p < .001) lower (1.25 0.48 1.33 0.46 ng/mL) compared controls. The prevalence AWMI 52%. both sexes (p .0007). Additionally, 39% elevated 38% reduced T3. No sex-based differences observed. found significant Although stress-induced dysfunction remains hypothesis, these findings suggest potential link T3, CVD. Further longitudinal research is needed explore causal mechanisms.

Language: Английский

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Risk Factors of Cardiovascular and Cerebrovascular Events in Patients With Uraemia Complicated With Hypertension During Maintenance Haemodialysis Treatment

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

Introduction: This study aimed to investigate the risk factors associated with major adverse cardiovascular (group of events that affect heart and blood vessels) cerebrovascular (events affecting vessels supplying brain) (MACCE) in patients uraemia complicated hypertension who required maintenance haemodialysis (MHD) treatment. Methodology: Clinical data laboratory indicators 156 were collected retrospectively analysed. The admitted a tertiary care hospital (Abbas Institute Medical Sciences AIMS) Muzaffarabad, Pakistan, from February 2018 2022. was through consecutive sampling recruited after following inclusion exclusion criteria. Results: Eighty-one out not MACCE, 75 MACCE during MHD treatment cycle, an incidence 48.08%. Compared non-MACCE group, group’s diabetes, body mass growth rate, triglyceride (TG), NT-proBNP, standard deviation coefficient variance for systolic diastolic pressure (SBP-SD, SBP-CV, DBP-SD, DBP-CV) showed significant differences (P<0.05) between groups. Diabetes, TG, SBP-SD, DBP-CV odds ratios 3.074, 3.202, 2.188, 2.512, 2.357, 2.431, 2.299, 2.062 respectively hypertension. Conclusion: From results this study, we inferred by cycle related DBP-CV.

Language: Английский

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Risk factors for cardiovascular and cerebrovascular events in patients with uremia and hypertension during maintenance hemodialysis

American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(4), P. 1228 - 1236

Published: Jan. 1, 2024

This study aimed to investigate risk factors for major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with uremia hypertension during maintenance hemodialysis (MHD).

Language: Английский

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Higher dietary inflammatory index linked to increased risk of hypertension: a systematic review and dose-response meta-analysis

European Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Language: Английский

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