Hypertension: A Continuing Public Healthcare Issue

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 123 - 123

Published: Dec. 26, 2024

Hypertension is a cardiovascular disease defined by an elevated systemic blood pressure. This devastating afflicts 30–40% of the adult population worldwide. The burden for hypertension great, and it greatly increases risk morbidity mortality. Unfortunately, there are myriad factors that result in These include genetic factors, sedentary lifestyle, obesity, salt intake, aging, stress. Although lifestyle modifications have had limited success, anti-hypertensive drugs been moderately effective lowering New approaches to control treat digital health tools compounds activate angiotensin receptor type 2 (AT2), which can promote health. Nonetheless, research on its management vital lessening significant economic this condition.

Language: Английский

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Predictive ability of traditional and novel anthropometric measurement indices for cardio-metabolic diseases in Chinese adults: China Health and Nutrition Survey (CHNS) cohort study

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2023, Volume and Issue: 33(4), P. 737 - 748

Published: Jan. 5, 2023

Language: Английский

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Sex Differences in the Impact of BMI on Length of Hospital Stay in Hypertensive Patients Admitted to a Cardiology Department: A Retrospective Cohort Study

Vascular Health and Risk Management, Journal Year: 2024, Volume and Issue: Volume 20, P. 579 - 591

Published: Dec. 1, 2024

Body mass index (BMI), as a straightforward measure, is widely used in clinical practice, and its results are linked to HT patient prognosis. This study aimed ascertain if sex differences exist the prognostic significance of BMI at time admission cardiology unit, how this impacts LOHS for patients suffering from hypertension.

Language: Английский

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Calcium Channel Blockade Mediates the Vasorelaxant Activity of Dichloromethane Extract from Roots of Oncidium cebolleta on Isolated Rat Aorta

Biointerface Research in Applied Chemistry, Journal Year: 2022, Volume and Issue: 13(1), P. 80 - 80

Published: Feb. 6, 2022

Oncidium cebolleta belongs to the Orchidaceae family, and it is used in preparations Mexican traditional medicine treat several diseases. This research aimed study vasorelaxant activity of dichloromethane extract from roots (DEROc) on endothelium-intact -removed rat aorta segments determine its mode action. Several extracts (hexane, dichloromethane, methanol) obtained leaves were evaluated isolated rings with without endothelium their effect. Except for methanolic leaves, all induced a concentration-dependent effect pre-contracted noradrenaline (NA, 0.1 µM). Dichloromethane was most potent efficient, endothelium-independent. Also, DEROc could relax KCl-induced contraction (80 mM) inhibit by CaCl2-cumulative concentration endothelium-denuded rings. However, less than control nifedipine (L-type calcium channel blocker), but effectiveness similar. Contractions NA 5-HT [0.001 µM µM] significantly reduced DEROc. vasorelaxation not TEA (potassium blocker, 10 nor ODQ (soluble guanylyl cyclase inhibitor, µM) aortic Our functional results suggest that induces relaxant an endothelium-independent mechanism due Ca2+ channels blockade

Language: Английский

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Body Mass Index and Risk for Hypertension of Adults with Type 2 Diabetes Mellitus Body Mass Index and Risk for Hypertension of Adults with Type 2 Diabetes Mellitus

Journal of Pharmaceutical Negative Results, Journal Year: 2022, Volume and Issue: 13(SO3)

Published: Jan. 1, 2022

Obesity has been proven to significantly increase the prevalence of hypertension and limiting effectiveness antihypertensive drug therapy.Several different studies have reported an in risk rising blood pressure individuals with higher BMI.Multiple claim independent correlation between sex, age, race towards changes onset risks.A multicenter observational study was conducted cross-sectional approach on 153 GLD controlled T2DM patients.Data GLD, doses, HbA1c, first time being diagnosed T2DM, symptoms heart failure, weight BMI will be extracted from medical record.Correlative Analysis Hypertension Chi Square Spearman test.Stratum analysis Hypertension, BMI, diabetes Square.The results showed that 98 (64.1%) respondents develop 63 them overweight (BMI > 25).BMI a not significant yet positively linear relation compared normoweight counterpart (OR 1.39, 95% CI 0.71 -2.74; p = 0.39).

Language: Английский

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Fractalkine levels in patients with type 2 diabetes mellitus with various body weight

Clinical endocrinology and endocrine surgery, Journal Year: 2023, Volume and Issue: 1, P. 20 - 25

Published: March 30, 2023

The obesity and diabetes mellitus (DM) are considered as concomitant pathologies in the most cases. risk of developing cardiovascular overall mortality increases even when upper limit normal body weight is reached. chemokine family important pathogenesis diseases, it activates leukocytes provokes their adhesion to vascular wall, i.e., inflammation endothelium, plays an role at all stages diseases (CVD). Objective — investigate fractalkine level patients with type 2 various weights establish correlations between factors, cytokine levels, morpho functional parameters heart. Materials methods. Examinations involved 100 DM normal, overweight, varying degrees; control group consisted 10 practically healthy subjects. mean age was 47.9±3.4 years. Patients didn’t have history CVD or signs during examinations, part from arterial hypertension. Echocardiography assessment levels were performed patients. Results. A significantly higher found compared group. There a significant increase this indicator depending on mass index. It that there direct correlation average strength index (r=0.45; p=0.0001), thickness left ventricular posterior wall (r=0.53; p=0.0005), myocardial (r=0.589; atrium (r=0.49; p=0.0005); strong waist circumference (r=0.72; p<0.0001), moderate total cholesterol (r=0.46; (r=0.62; p<0.00001) glycated hemoglobin. also relationship interleukin‑6 (0.69; p=0.0005) C‑reactive protein (0.63; p<0.00001), (r=0.63 leptin levels. Conclusions. study results demonstrated DM, index, blood increases, which closely correlates circumference, indicators carbohydrate lipid metabolism, pro‑inflammatory cytokines. thickness, ventricular, atrial

Language: Английский

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Hypertension Among Persons Living With HIV/Aids and Its Association With Hiv-Related Health Factors

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 17, 2023

Abstract Background Human Immunodeficiency Virus ( HIV) infection remains a public health concern in many countries. The increased life expectancy the post-Antiretroviral Therapy (ART) era has led to an risk of cardiovascular disease and death among Persons Living with HIV (PLHIV). Hypertension significant factor for PLHIV. Some studies have suggested associations between hypertension PLHIV HIV-related factors. Objective To determine prevalence on antiretroviral medications examine its association Methods A cross-sectional study was conducted attendants at adult clinic. 362 participants were selected by systematic sampling. Data diagnosis, factors, sociodemographic other traditional factors collected using standardized questionnaire patient chart review. Multivariate logistic regression model used adjusting hypertension. Results mean age 47.9 years majority female (77.1%). 42% had been > 10 years. 17.4%. Age 50 associated higher odds (aOR:3.75, 95%CI:1.68,8.55, p-value:0.002). BMI overweight obese categories, history comorbid medical conditions (diabetes, hyperlipidemia) also (aOR:3.76, 95%CI:1.44,9.81, p-value:0.007), (aOR:3.17, 95%CI:1.21,8.32, p-value:0.019) (aOR:14.25, 95%CI:7.41,27.41, p-value:<0.001) respectively. No Conclusion common condition medications. Traditional years, BMI, conditions.

Language: Английский

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Evaluation of Clotting Parameters in Pregnant Women with Placental Blood Clots: Impact of Patient Characteristics and Assessment of Clexane Efficacy

Azerbaijan Pharmaceutical and Pharmacoterapy Journal, Journal Year: 2023, Volume and Issue: 22(2), P. 83 - 91

Published: Dec. 31, 2023

Background: Clexane is used in pregnant women (PW) to minimize placental blood clotting (PBC) and fetal danger. Standard coagulation tests such as prothrombin time (PT), activated partial thromboplastin (APTT), international normalized ratio (INR) are critical for anticoagulant medication optimization. As a result, the study's goal was evaluate efficacy of clexane well adherence American Heart Association's recommended limits routine tests. Methods: The study included forty normal PW controls with PBC patients from Al-Mafraq Hospital Jordan. Patients were administered daily subcutaneous injections 40 mg an anticoagulant, conjunction 75 aspirin regimen. During first trimester, 5 ml venous drawn each participant. PT, INR APTT measured. This assessment also considered variables including plasma fibrinogen concentration (PFC), age, body mass index (BMI), type, gender. Results: mean age \(\pm\) SD 29.6 6.2 patient group 28.3 5.9 years control group. changes INR, PFC between groups statistically significant independent mother's BMI, baby gender, or type. displayed inadequate anticoagulation 0.8, falling below therapeutic range 2-3 treatment. Surprisingly, by end clinical study, all under investigation had safely delivered their babies without difficulties. Conclusion: observed rise levels among may contribute formation, necessitating further investigation. Evaluation safety combined regimen region, Jordan, warranted.

Language: Английский

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Association of the PDE4D gene variant with selected markers in individuals with ischaemic heart disease: a pilot study

Central European Journal of Public Health, Journal Year: 2023, Volume and Issue: 31(Suppl 1), P. S75 - S81

Published: Dec. 31, 2023

Objective: The aim of the study was to evaluate variant (rs2910829) PDE4D gene in relation its influence on biochemical, anthropometric and physiological parameters patients with coronary artery disease healthy subjects Eastern Slovak population. Methods: male group consisted 72 individuals female 132 individuals. On basis clinical screening were divided into two groups - ischaemic heart control group. Genomic DNA isolated from peripheral blood using a commercial NucleoSpin® Blood Machenery-Nagel kit. Molecular genetic analysis polymorphism under performed StepOne™ Real-Time PCR System instrument. lipid profile markers TC, HDL, LDL, TG measured by Cobas Integra 400 plus biochemical analyser, systolic diastolic pressure digital monitor. Among parameters, body height weight, waist hip circumference BMI WHR indices calculated. Results: A statistically significant (p = 0.018) possible association between mutant T allele found men. In women, we difference 0.013) 0.005) CC genotype. differences all observed LDL TC markers. men BMI, statistical significance 0.028). women disease, negative correlation HDL. Conclusion: contributes new findings representation genotypes alleles rs2910829 This is pilot study. Interactions genotype anthropometric, confirmed.

Language: Английский

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