Neuroimaging-Based Glymphatic Function Predicts Conversion from Prodromal to Manifest Parkinson's Disease DOI
Amei Chen,

Zhanyu Kuang,

Pek‐Lan Khong

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract This study investigated glymphatic system integrity in prodromal Parkinson’s disease (pPD) using diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) technique, analyzing data from 51 healthy controls, 83 pPD individuals, and 202 de novo (dnPD) patients. The DTI-ALPS index was significantly reduced both dnPD groups compared to controls correlated with anxiety scores cerebrospinal fluid tau levels group. Longitudinal revealed that a higher associated lower risk of conversion clinical PD, suggesting dysfunction may serve as predictive biomarker for progression.

Language: Английский

Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke DOI
Diana Alsbrook, Mario Di Napoli, Kunal Bhatia

et al.

Current Neurology and Neuroscience Reports, Journal Year: 2023, Volume and Issue: 23(8), P. 407 - 431

Published: July 3, 2023

Language: Английский

Citations

157
The translational neuroscience of sleep: A contextual framework DOI
Michael A. Grandner, Fabian‐Xosé Fernandez

Science, Journal Year: 2021, Volume and Issue: 374(6567), P. 568 - 573

Published: Oct. 28, 2021

Sleep is entwined across many physiologic processes in the brain and periphery, thereby exerting tremendous influence on our well-being. Yet sleep exists a social-environmental context. Contextualizing health with respect to its determinants—from individual- societal-level factors—would enable neuroscientists more effectively translate into clinical practice. Key challenges opportunities pertain (i) recognizing exploring sleep’s functional roles, (ii) clarifying causal mechanisms relation key outcomes, (iii) developing richer model systems, (iv) linking models known contextual factors, (v) leveraging advances multisensory technology. Meeting these would help transcend disciplinary boundaries such that considerations related become an ever-greater presence clinic.

Language: Английский

Citations

115
Metabolic Contribution and Cerebral Blood Flow Regulation by Astrocytes in the Neurovascular Unit DOI Creative Commons
Shinichi Takahashi

Cells, Journal Year: 2022, Volume and Issue: 11(5), P. 813 - 813

Published: Feb. 25, 2022

The neurovascular unit (NVU) is a conceptual framework that has been proposed to better explain the relationships between neural cells and blood vessels in human brain, focused mainly on brain gray matter. major components of NVU are neurons, astrocytes (astroglia), microvessels, pericytes, microglia. In addition, we believe oligodendrocytes should also be included as an indispensable component white Of all these components, particular have attracted interest researchers because their unique anatomical location; interposed neurons microvessels brain. Their location suggests might regulate cerebral flow (CBF) response neuronal activity, so ensure adequate supply glucose oxygen meet metabolic demands neurons. fact, adult which accounts for only 2% entire body weight, consumes approximately 20–25% total amount consumed by whole body. needs continuous essential energy sources through CBF, there practically no stores or brain; both acute chronic cessation CBF can adversely affect functions. another important putative function elimination heat waste materials produced activity. Recent evidence play pivotal roles not supplying glucose, but fatty acids amino Loss astrocytic support expected lead malfunction whole, underlies numerous neurological disorders. this review, shall focus historical recent findings with regard contributions NVU.

Language: Английский

Citations

57
The glymphatic system’s role in traumatic brain injury-related neurodegeneration DOI
Matthew E. Peters, Constantine G. Lyketsos

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(7), P. 2707 - 2715

Published: April 25, 2023

Language: Английский

Citations

30
Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm DOI
Rüssel J. Reiter, Ramaswamy Sharma, Maira Smaniotto Cucielo

et al.

Cellular and Molecular Life Sciences, Journal Year: 2023, Volume and Issue: 80(4)

Published: March 14, 2023

Language: Английский

Citations

29
The nasal lymphatic route of CSF outflow: implications for neurodegenerative disease diagnosis and monitoring DOI Creative Commons
J. Chae, Mina Choi,

Juyoung Choi

et al.

Animal Cells and Systems, Journal Year: 2024, Volume and Issue: 28(1), P. 45 - 54

Published: Jan. 29, 2024

Cerebrospinal fluid (CSF) plays a crucial role in the brain's lymphatics as it traverses central nervous system (CNS). Its primary function is to facilitate outward transport of waste. Among various CSF outflow pathways, route through cribriform plate along olfactory nerves stands out most predominant. This review describes pathway into nasal lymphatics. Additionally, we examine existing studies describe mutual influences observed between brain and extracranial regions due this pathway. Notably, pathological conditions CNS often influence outflow, leading observable changes regions. The established connection nose significant, our underscores its potential relevance monitoring ailments, including neurodegenerative diseases. Considering that aging – significant risk factor for onset neurodegeneration also principal turnover alterations, suggest novel approach studying diseases therapeutic terms.

Language: Английский

Citations

12
Perivascular enhancement pattern: Identification, Diagnostic spectrum and Practical approach – A pictorial review DOI Creative Commons

Matthias Babin,

Marianne Golse,

Manel Khaterchi

et al.

Journal of Neuroradiology, Journal Year: 2025, Volume and Issue: 52(3), P. 101242 - 101242

Published: Jan. 17, 2025

Language: Английский

Citations

1
Near-Infrared Imaging of Glymphatic Clearance in a Pre-Clinical Model of Repetitive Closed Head Traumatic Brain Injury DOI Creative Commons
Eleftheria Michalaki, Alexis N. Pulliam,

Pooja M. Datta Roy

et al.

Neurotrauma Reports, Journal Year: 2025, Volume and Issue: 6(1), P. 115 - 128

Published: Jan. 1, 2025

Traumatic brain injury (TBI) is a major health disorder for which there are few treatments. The glymphatic system the brain's inbuilt lymphatic-like that thought to be responsible clearing waste products from lymph nodes. Although evidence drainage crucial homeostasis, its role in TBI pathogenesis remains elusive. Here, we investigated how clearance altered following rats using real-time non-invasive imaging. Twenty-four hours repetitive closed-head or sham conditions, injected infrared dye intraventricularly and used near-infrared (NIR) imaging quantify signal intensity, intensity over time, appearance time of NIR different regions. yielded lower rate change lateral ventricle surrounding parietal cortex compared with indicating reduced cerebrospinal fluid perfusion. took significantly longer reach anterior regions brain, while perfusion posterior was faster animals. Aquaporin-4 (AQP4) expression 24 h after across all cortical examined ventral at coronal levels, suggesting complex relationship between AQP4 glymph function. Furthermore, revealed detectable cervical nodes (CLNs) animals but not animals, yet blood accumulation CLNs TBI-related extravascular removed through system. These data indicate disrupts normal efflux kinetics reduces CLNs, demonstrating restoring function may promising therapeutic target.

Language: Английский

Citations

1
Molecular, Pathological, Clinical, and Therapeutic Aspects of Perihematomal Edema in Different Stages of Intracerebral Hemorrhage DOI Creative Commons
Chao Jiang, Hengtao Guo, Zhiying Zhang

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 38

Published: Sept. 17, 2022

Acute intracerebral hemorrhage (ICH) is a devastating type of stroke worldwide. Neuronal destruction involved in the brain damage process caused by ICH includes primary injury formed mass effect hematoma and secondary induced degradation products blood clot. Additionally, factors coagulation cascade complement activation also contribute to promoting disruption blood-brain barrier neuronal cell degeneration enhancing inflammatory response, oxidative stress, etc. Although treatment options for direct are limited, various strategies have been proposed treat post-ICH. Perihematomal edema (PHE) potential surrogate marker may poor outcomes after ICH. Therefore, it essential investigate underlying pathological mechanism, evolution, therapeutic PHE. Here, we review pathophysiology imaging characteristics PHE at different stages acute As illustrated preclinical clinical studies, discussed merits limitations varying quantification protocols, including absolute volume, relative extension distance calculated with images other techniques. Importantly, this summarizes that affect focusing on traditional variables, cerebral venous drainage system, lymphatic system. Finally, facilitate translational research, analyze why relationship between functional outcome currently controversial. We emphasize promising approaches modulate multiple targets alleviate promote neurologic recovery

Language: Английский

Citations

30
DTI-ALPS index decreased in patients with Type 2 Diabetes Mellitus DOI Creative Commons

Shuncheng Yu,

Jiang Hongjun,

Langxuan Yu

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 22, 2024

Backgrounds Type 2 Diabetes Mellitus (T2DM) has become a significant global public health issue, characterized by rising prevalence and associated deficits across multiple organ systems. Our study aims to utilize the DTI-ALPS technique assess change of ALPS index in T2DM patients, explore whether such changes are correlated with cognition level diffusion parameters. Methods The involved 41 patients (mean age, 60.49 ± 8.88 years) 27 healthy controls 58.00 7.63 years). All subjects underwent MRI examination, cognitive assessment, laboratory tests. Tract-based spatial statistics (TBSS) was used evaluate white matter changes. GLM performed check difference between HC groups. Spearman correlation analysis partial were analyze properties & scores. Results results show that lower patients. MoCA score significantly index. Patients had increase both mean diffusivity (MD) radial (RD) decrease fractional anisotropy (FA) compared group. Conclusion suggest is decreased associates level.

Language: Английский

Citations

8