NeuroImmune Pharmacology and Therapeutics,
Journal Year:
2024,
Volume and Issue:
3(2), P. 97 - 111
Published: June 1, 2024
Although
treatable
with
antiretroviral
therapy,
HIV
infection
persists
in
people
living
(PLWH).
It
is
well
known
that
the
virus
finds
refuge
places
for
which
medications
do
not
reach
therapeutic
levels,
mainly
CNS.
clear
as
PLWH
age,
likelihood
of
developing
HIV-associated
neurological
deficits
increases.
At
biochemical
level
dysfunction
manifestation
altered
cellular
function
and
ineffective
intercellular
communication.
In
this
review,
we
examine
how
signaling
brain
disrupted
context
HIV.
Specifically,
concept
blood-brain
barrier
can
be
a
convergence
point
crosstalk,
explored.
Crosstalk
between
cells
neurovascular
unit
(NVU)
(endothelium,
pericytes,
astrocytes,
microglia
neurons)
critical
maintaining
proper
function.
fact,
NVU
allows
rapid
matching
neuronal
metabolic
needs,
regulation
(BBB)
dynamics
nutrient
transport
changes
to
immunosurveillance.
This
review
invites
reader
conceptually
consider
BBB
router
or
facilitate
better
understanding
intricate
events
underpin
during
associated
neuropathology.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(19), P. 10535 - 10535
Published: Sept. 30, 2024
Progress
made
by
the
medical
community
in
increasing
lifespans
comes
with
costs
of
incidence
and
prevalence
age-related
diseases,
neurodegenerative
ones
included.
Aging
is
associated
a
series
morphological
changes
at
tissue
cellular
levels
brain,
as
well
impairments
signaling
pathways
gene
transcription,
which
lead
to
synaptic
dysfunction
cognitive
decline.
Although
we
are
not
able
pinpoint
exact
differences
between
healthy
aging
neurodegeneration,
research
increasingly
highlights
involvement
neuroinflammation
chronic
systemic
inflammation
(inflammaging)
development
age-associated
via
pathogenic
cascades,
triggered
dysfunctions
circadian
clock,
gut
dysbiosis,
immunosenescence,
or
impaired
cholinergic
signaling.
In
addition,
gender
susceptibility
course
neurodegeneration
that
appear
be
mediated
glial
cells
emphasize
need
for
future
this
area
an
individualized
therapeutic
approach.
rejuvenation
still
its
very
early
infancy,
accumulated
knowledge
on
various
involved
promoting
senescence
opens
perspective
interfering
these
preventing
delaying
senescence.
Journal of Neurochemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 29, 2024
Abstract
The
neurovascular
unit,
composed
of
vascular
endothelium,
smooth
muscle,
extracellular
matrix
components,
pericytes,
astrocytes,
microglia,
and
neurons,
allows
the
highly
regulated
exchange
molecules
limited
trafficking
cells
to
brain
through
coordinated
signaling
activity.
passage
peripheral
immune
parenchyma
is
observed
when
there
clear
damage
barriers
this
as
occurs
in
traumatic
injury.
possibility
leukocyte
infiltration
neurodegenerative
conditions
has
been
proposed.
In
review,
we
focus
on
describing
evidence
for
cell
two
most
frequent
diseases:
Alzheimer's
Parkinson's
diseases.
particular,
address
mechanisms
that
promote
these
into
under
such
pathological
conditions.
We
also
discuss
relevance
resulting
cellular
interactions,
which
provide
presence
a
key
point
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(14), P. 3106 - 3106
Published: July 11, 2023
This
comprehensive
narrative
review
explores
the
concept
of
neuro-vulnerability
in
energy
metabolism
regulation
and
its
implications
for
metabolic
disorders.
The
highlights
complex
interactions
among
neural,
hormonal,
pathways
involved
metabolism.
key
topics
discussed
include
role
organs,
hormones,
neural
circuits
maintaining
balance.
investigates
association
between
disorders,
such
as
obesity,
insulin
resistance,
eating
considering
genetic,
epigenetic,
environmental
factors
that
influence
subsequent
dysregulation.
Neuroendocrine
food
intake
expenditure
are
examined,
with
a
focus
on
impact
appetite
dysregulation
altered
expenditure.
neuroinflammation
health
is
discussed,
emphasizing
bidirectional
relationship
neuroinflammatory
processes.
also
evaluates
use
neuroimaging
techniques
studying
their
potential
applications
clinical
settings.
Furthermore,
well
contribution
to
examined.
Potential
therapeutic
interventions
targeting
neuro-vulnerability,
including
pharmacological
treatments
lifestyle
modifications,
reviewed.
In
conclusion,
understanding
crucial
addressing
provides
valuable
insights
into
underlying
neurobiological
mechanisms
health.
Targeting
holds
promise
developing
innovative
strategies
prevention
treatment
ultimately
improving
outcomes.
Neuroscience Bulletin,
Journal Year:
2024,
Volume and Issue:
40(5), P. 621 - 634
Published: March 30, 2024
Epilepsy
is
a
multifaceted
neurological
syndrome
characterized
by
recurrent,
spontaneous,
and
synchronous
seizures.
The
pathogenesis
of
epilepsy,
known
as
epileptogenesis,
involves
intricate
changes
in
neurons,
neuroglia,
endothelium,
leading
to
structural
functional
disorders
within
neurovascular
units
culminating
the
development
spontaneous
epilepsy.
Although
current
research
on
epilepsy
treatments
primarily
centers
around
anti-seizure
drugs,
it
imperative
seek
effective
interventions
capable
disrupting
epileptogenesis.
To
this
end,
comprehensive
exploration
molecular
mechanisms
underlying
epileptogenesis
holds
promise
identifying
vital
biomarkers
for
accurate
diagnosis
potential
therapeutic
targets.
Emphasizing
early
timely
intervention
paramount,
stands
significantly
improve
patient
prognosis
alleviate
socioeconomic
burden.
In
review,
we
highlight
unit
provide
theoretical
basis
drug
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(14), P. 3189 - 3189
Published: July 19, 2023
The
Euterpe
genus
(mainly
oleracea
Martius,
precatoria
and
edulis
Martius)
has
recently
gained
commercial
scientific
notoriety
due
to
the
high
nutritional
value
of
its
fruits,
which
are
rich
in
polyphenols
(phenolic
acids
anthocyanins)
have
potent
antioxidant
activity.
These
characteristics
contributed
increased
number
neuropharmacological
evaluations
three
species
over
last
10
years,
especially
açaí
Martius.
fruits
exert
neuroprotective
effects
through
modulation
inflammatory
oxidative
pathways
other
mechanisms,
including
inhibition
mTOR
pathway
protection
blood–brain
barrier,
all
them
intimately
involved
several
neuropathologies.
Thus,
a
better
understanding
properties
these
may
open
new
paths
for
development
therapeutic
tools
aimed
at
preventing
treating
variety
neurological
conditions.
