Oxidative Stress and Age-Related Tumors

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1109 - 1109

Published: Sept. 13, 2024

Oxidative stress is the result of imbalance between reactive oxygen and nitrogen species (RONS), which are produced by several endogenous exogenous processes, antioxidant defenses consisting molecules that protect biological systems from free radical toxicity. a major factor in aging process, contributing to accumulation cellular damage over time. biomolecules, leads DNA alterations, lipid peroxidation, protein oxidation, mitochondrial dysfunction resulting senescence, immune system tissue dysfunctions, increased susceptibility age-related pathologies, such as inflammatory disorders, cardiovascular neurodegenerative diseases, diabetes, cancer. stress-driven mutations, or methylation histone modification, alter gene expression, key determinants tumor initiation, angiogenesis, metastasis, therapy resistance. Accumulation genetic epigenetic damage, oxidative contributes, eventually unrestrained cell proliferation, inhibition differentiation, evasion death, providing favorable conditions for tumorigenesis. Colorectal, breast, lung, prostate, skin cancers most frequent aging-associated malignancies, implicated their pathogenesis behavior. Our aim shed light on molecular mechanisms link stress, aging, cancers, highlighting impact both RONS antioxidants, provided diet exercise, immunity, development an antitumor response. The dual role ROS physiological regulators signaling responsible well its use anti-tumor therapeutic purposes, will also be discussed. Managing crucial promoting healthy reducing risk tumors.

Language: Английский

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HAP/ClpP-Mediated Disaggregation and Degradation of Mutant SOD1 Aggregates: A Potential Therapeutic Strategy for Amyotrophic Lateral Sclerosis (ALS)

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151533 - 151533

Published: Feb. 1, 2025

Language: Английский

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Amyotrophic lateral sclerosis caused by SOD1 variants: from genetic discovery to disease prevention

The Lancet Neurology, Journal Year: 2024, Volume and Issue: 24(1), P. 77 - 86

Published: Dec. 18, 2024

Language: Английский

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The Current Potential Pathogenesis of Amyotrophic Lateral Sclerosis

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: June 3, 2024

Language: Английский

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