Microglia emerge as central players in brain disease

Nature Medicine, Journal Year: 2017, Volume and Issue: 23(9), P. 1018 - 1027

Published: Sept. 1, 2017

Language: Английский

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Negative feedback control of neuronal activity by microglia

Nature, Journal Year: 2020, Volume and Issue: 586(7829), P. 417 - 423

Published: Sept. 30, 2020

Language: Английский

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Microglia: Dynamic Mediators of Synapse Development and Plasticity

Trends in Immunology, Journal Year: 2015, Volume and Issue: 36(10), P. 605 - 613

Published: Oct. 1, 2015

Language: Английский

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Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

The Journal of Physiology, Journal Year: 2016, Volume and Issue: 595(6), P. 1929 - 1945

Published: April 22, 2016

Microglia are the only immune cells that permanently reside in central nervous system (CNS) alongside neurons and other types of glial cells. The past decade has witnessed a revolution our understanding their roles during normal physiological conditions. Cutting-edge techniques revealed these resident critical for proper brain development, actively maintain health mature brain, rapidly adapt function to or pathophysiological needs. In this review, we highlight recent studies on microglial origin (from embryonic yolk sac) factors regulating differentiation homeostasis upon invasion. Elegant experiments tracking microglia CNS allowed unique compared with macrophages. Here review emerging plasticity cognition, discuss implications depletion dysfunction disease pathogenesis. Immune activation, inflammation various conditions resulting undesirable activity at different stages life could severely impair learning, memory essential cognitive functions. diversity phenotypes across lifespan, between compartments CNS, sexes, as well crosstalk body external environment, is also emphasised. Understanding what defines particular major importance future development innovative therapies controlling effector functions, consequences cognition chronic stress, ageing, neuropsychiatric neurological diseases.

Language: Английский

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Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity

Cell, Journal Year: 2020, Volume and Issue: 182(2), P. 388 - 403.e15

Published: July 1, 2020

Language: Английский

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Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

Nature Communications, Journal Year: 2016, Volume and Issue: 7(1)

Published: March 7, 2016

Abstract Microglia are the resident immune cells of brain. Increasingly, they recognized as important mediators normal neurophysiology, particularly during early development. Here we demonstrate that microglia critical for ocular dominance plasticity. During visual period, closure one eye elicits changes in structure and function connections underlying binocular responses neurons cortex. We find respond to monocular deprivation altering their morphology, motility phagocytic behaviour well interactions with synapses. To explore mechanism, focused on P2Y12 purinergic receptor, which is selectively expressed non-activated mediates process injury responses. disrupting this receptor alters microglial response abrogates These results suggest actively contribute experience-dependent plasticity adolescent

Language: Английский

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The semantics of microglia activation: neuroinflammation, homeostasis, and stress

Journal of Neuroinflammation, Journal Year: 2021, Volume and Issue: 18(1)

Published: Nov. 6, 2021

Microglia are emerging as critical regulators of neuronal function and behavior in nearly every area neuroscience. Initial reports focused on classical immune functions microglia pathological contexts, however, immunological concepts from these studies have been applied to describe neuro-immune interactions the absence disease, injury, or infection. Indeed, terms such 'microglia activation' 'neuroinflammation' used ubiquitously changes disparate contexts; particularly stress research, where prompt undue comparisons conditions. This creates a barrier for investigators new neuro-immunology ultimately hinders our understanding effects microglia. As more seek understand role neurobiology behavior, it is increasingly important develop standard methods study define microglial phenotype function. In this review, we summarize primary research physiological contexts. Further, propose framework better microglia1 chronic stress. approach will enable precise characterization different which should facilitate development microglia-directed therapeutics psychiatric neurological disease.

Language: Английский

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Dual Functions of Microglia in Ischemic Stroke

Neuroscience Bulletin, Journal Year: 2019, Volume and Issue: 35(5), P. 921 - 933

Published: May 6, 2019

Language: Английский

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Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Sept. 22, 2023

Abstract Microglia activation is observed in various neurodegenerative diseases. Recent advances single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity. Some identified specific states correlate pathological hallmarks are associated functions. both exert protective function by phagocytosing clearing protein aggregates play detrimental roles due to excessive uptake of aggregates, which would lead microglial phagocytic ability impairment, neuroinflammation, eventually neurodegeneration. In addition, peripheral immune cells infiltration shapes into a pro-inflammatory phenotype accelerates disease progression. also act as mobile vehicle propagate aggregates. Extracellular vesicles released from autophagy impairment all contribute progression Thus, enhancing phagocytosis, reducing microglial-mediated inhibiting exosome synthesis secretion, promoting conversion considered be promising strategies for the therapy Here we comprehensively review biology diseases, including Alzheimer’s disease, Parkinson’s multiple system atrophy, amyotrophic lateral sclerosis, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, dementia Lewy bodies Huntington’s disease. We summarize possible microglia-targeted interventions treatments against diseases preclinical clinical evidence cell experiments, animal studies, trials.

Language: Английский

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Neuroinflammation in the central nervous system: Symphony of glial cells

Glia, Journal Year: 2018, Volume and Issue: 67(6), P. 1017 - 1035

Published: Dec. 11, 2018

Abstract Neuroinflammation in the central nervous system (CNS) is an important subject of neuroimmunological research. Emerging evidence suggests that neuroinflammation a key player various neurological disorders, including neurodegenerative diseases and CNS injury. complex well‐orchestrated process by groups glial cells peripheral immune cells. The cross‐talks between extremely dynamic which resembles symphony. However, understanding how interact with each other to shape distinctive responses remains limited. In this review, we will discuss joint actions three phases neuroinflammation, initiation, progression, prognosis, movements symphony, as role type depends on nature inflammatory cues specific course diseases. This perspective might provide helpful clues development early diagnosis therapeutic intervention

Language: Английский

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