The anterior fusiform gyrus: The ghost in the cortical face machine

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 158, P. 105535 - 105535

Published: Jan. 6, 2024

Face-selective regions in the human ventral occipito-temporal cortex (VOTC) have been defined for decades mainly with functional magnetic resonance imaging. This face-selective VOTC network is traditionally divided a posterior 'core' system thought to subtend face perception, and of anterior temporal lobe as semantic memory component an extended general system. In between these two putative systems lies fusiform gyrus surrounding sulci, affected by susceptibility artifacts. Here we suggest that this methodological gap overlaps contributes conceptual (visual) perception faces. Filling intracerebral recordings direct electrical stimulation reveals robust face-selectivity crucial role region, especially right hemisphere, identity recognition both familiar unfamiliar Based on observations, propose integrated theoretical framework (identity) according which join dots cortical memories.

Language: Английский

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Temporopolar regions of the human brain

Brain, Journal Year: 2022, Volume and Issue: 146(1), P. 20 - 41

Published: Nov. 4, 2022

Following prolonged neglect during the formative decades of behavioural neurology, temporopolar region has become a site vibrant research on neurobiology cognition and conduct. This turnaround can be attributed to increasing recognition neurodegenerative diseases that target regions for peak destruction. The resultant syndromes include dementia, associative agnosia, semantic forms primary progressive aphasia dementia. Clinicopathological correlations show object naming word comprehension are critically dependent language-dominant (usually left) region, whereas control non-verbal display more bilateral representation with rightward bias. Neuroanatomical experiments in macaques neuroimaging humans temporoparietal sits at confluence auditory, visual limbic streams processing downstream (deep) pole 'what' pathway. functional neuroanatomy this revolves around three axes, an anterograde horizontal axis from unimodal heteromodal paralimbic cortex; radial where (ventral), auditory (dorsal) (medial) territories encircle cortex hemispheric asymmetry; vertical depth-of-processing elaboration words, objects interoceptive states. One function neural matrix is support transformation representations percepts multimodal concepts. underlying process likely start canonical gateways successively lead generic (superordinate), specific (basic) unique levels recognition. A first sign left dysfunction takes form taxonomic blurring boundaries among categories preserved but not exemplars category. Semantic paraphasias coordinate errors word-picture verification tests consequences phenomenon. Eventually, also blurred impairments profound. medial belongs amygdalocentric component system stands integrate exteroceptive information states social interactions. Review pertinent literature shows conduct caused by strokes temporal lobectomy far less severe than those seen atrophies. explanation unexpected discrepancy invokes miswiring residual neurons many years indolently neurodegeneration. According hypothesis, only dysfunctional sources aberrant outputs interfere areas elsewhere language networks, juxtaposition or stroke.

Language: Английский

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Hippocampus and temporal pole functional connectivity is associated with age and individual differences in autobiographical memory

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(41)

Published: Oct. 3, 2022

Recollection of one’s personal past, or autobiographical memory (AM), varies across individuals and the life span. This manifests in amount episodic content recalled during AM, which may reflect differences associated functional brain networks. We take an individual approach to examine resting-state connectivity temporal lobe regions known coordinate AM retrieval with default network (anterior posterior hippocampus, pole) test for associations AM. Multiecho magnetic resonance imaging (fMRI) interviews were collected 158 younger 105 older healthy adults. Interviews scored internal (episodic) external (semantic) details. Age group profiles revealed that adults had lower within anterior pole but greater compared pattern was positively related hippocampal volumes adults, smaller than adult volumes. Connectivity showed two significant patterns. The first dissociated vs. participants. Internal hippocampus orbitofrontal cortex hippocampus. External lateral cortex. In second pattern, displayed throughout more detailed AMs overall. Our findings provide evidence discrete ensembles scale systematic variation recollective styles

Language: Английский

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Graded and sharp transitions in semantic function in left temporal lobe

Brain and Language, Journal Year: 2024, Volume and Issue: 251, P. 105402 - 105402

Published: March 13, 2024

Recent work has focussed on how patterns of functional change within the temporal lobe relate to whole-brain dimensions intrinsic connectivity variation (Margulies et al., 2016). We examined two such 'connectivity gradients' reflecting separation (i) unimodal versus heteromodal and (ii) visual auditory-motor cortex, examining visually presented verbal associative feature judgments, plus picture-based context emotion generation. Functional responses along first dimension sometimes showed graded between modality-tuned cortex (in matching task), other times sharp transitions, with deactivation at extremes activation in middle this gradient (internal generation). The second revealed more than activation, regardless content (associative, feature, context, emotion) or task process (matching/generation). also uncovered subtle differences across each for type, which predominantly manifested as relative magnitude deactivation.

Language: Английский

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How does the “default mode” network contribute to semantic cognition?

Brain and Language, Journal Year: 2024, Volume and Issue: 252, P. 105405 - 105405

Published: April 4, 2024

Language: Английский

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Intracerebral electrical stimulation of the right anterior fusiform gyrus impairs human face identity recognition

NeuroImage, Journal Year: 2022, Volume and Issue: 250, P. 118932 - 118932

Published: Jan. 24, 2022

Brain regions located between the right fusiform face area (FFA) in middle gyrus and temporal pole may play a critical role human identity recognition but their investigation is limited by large signal drop-out functional magnetic resonance imaging (fMRI). Here we report an original case who suddenly unable to recognize of faces when electrically stimulated on focal location inside this intermediate region anterior gyrus. The reliable transient deficit occurs without any change percept, even during nonverbal tasks (i.e., pointing out famous picture among three options; matching pictures unfamiliar or familiar for identities), difficulty at recognizing visual objects written names. effective contact associated with largest frequency-tagged electrophysiological signals face-selectivity recognition. This extensive multimodal points as hub cortical network, posterior ventral occipito-temporal face-selective directly connected low-level cortex, medial lobe involved generic memory encoding, holding semantic associations people's identity.

Language: Английский

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Amygdala function in emotion, cognition, and behavior

Handbook of clinical neurology, Journal Year: 2022, Volume and Issue: unknown, P. 359 - 380

Published: Jan. 1, 2022

Language: Английский

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The role of the ventrolateral anterior temporal lobes in social cognition

Human Brain Mapping, Journal Year: 2022, Volume and Issue: 43(15), P. 4589 - 4608

Published: June 18, 2022

A key challenge for neurobiological models of social cognition is to elucidate whether brain regions are specialised that domain. In recent years, discussion surrounding the role anterior temporal epitomises such debates; some argue lobe (ATL) part a domain-specific network processing, while others claim it comprises domain-general hub semantic representation. present study, we used ATL-optimised fMRI map contribution different ATL structures variety paradigms frequently probe crucial ability, namely 'theory mind' (ToM). Using multiple tasks enables clearer attribution activation ToM as opposed idiosyncratic features stimuli. Further, directly explored these same also activated by non-social task probing representations. We revealed common all was ventrolateral region often invisible standard fMRI. This constitutes novel evidence in support view contributes via processing and against claims function.

Language: Английский

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Intracerebral Electrophysiological Recordings to Understand the Neural Basis of Human Face Recognition

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(2), P. 354 - 354

Published: Feb. 18, 2023

Understanding how the human brain recognizes faces is a primary scientific goal in cognitive neuroscience. Given limitations of monkey model face recognition, key approach this endeavor recording electrophysiological activity with electrodes implanted inside epileptic patients. However, number challenges that must be overcome for meaningful knowledge to emerge. Here we synthesize 10 year research program combining intracerebral (StereoElectroEncephaloGraphy, SEEG) ventral occipito-temporal cortex (VOTC) large samples participants and fast periodic visual stimulation (FPVS), objectively define, quantify, characterize neural basis recognition. These large-scale studies reconcile wide distribution recognition its (right) hemispheric regional specialization extend face-selectivity anterior regions VOTC, including temporal lobe (VATL) typically affected by magnetic susceptibility artifacts functional resonance imaging (fMRI). Clear spatial dissociations category-selectivity between other stimuli such as landmarks (houses, medial VOTC regions) or written words (left lateralized VOTC) are found, confirming extending neuroimaging observations while supporting validity clinical population tested inform about normal function. The identity - arguably ultimate form beyond mere differences physical features essentially supported selective populations neurons right inferior occipital gyrus lateral portion middle fusiform gyrus. In addition, low-frequency high-frequency broadband iEEG signals appear largely concordant association cortex. We conclude outlining understand next years.

Language: Английский

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The “limbic network,” comprising orbitofrontal and anterior temporal cortex, is part of an extended default network: Evidence from multi-echo fMRI

Network Neuroscience, Journal Year: 2024, Volume and Issue: 8(3), P. 860 - 882

Published: Jan. 1, 2024

Abstract Resting-state functional magnetic resonance imaging (fMRI) investigations have provided a view of the default network (DN) as composed specific set frontal, parietal, and temporal cortical regions. This spatial topography is typically defined with reference to an influential parcellation scheme that designated DN one seven large-scale networks (Yeo et al., 2011). However, precise organization still under debate, studies arguing for varying subnetwork configurations inclusion subcortical In this vein, so-called limbic network—defined distinct comprising bilateral poles, ventral anterior lobes, orbitofrontal cortex—is particular interest. A large multi-modal multi-species literature on anatomical, functional, cognitive properties these regions suggests close relationship DN. Notably, poor signal quality conventional fMRI acquisition, likely obscuring their affiliation in most studies. Here, we leverage multi-echo dataset high signal-to-noise whole-brain coverage, including regions, examine resting-state connectivity assess associations Consistent our hypotheses, results support majority cortex part reveal significant heterogeneity connectivity. We observed left-lateralized within poles well medial exhibited greatest DN, across subnetworks. Overall, findings suggest that, rather than being functionally network, comprise larger, extended network.

Language: Английский

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