Adult neurogenesis and “immature” neurons in mammals: an evolutionary trade-off in plasticity? DOI Creative Commons
Luca Bonfanti, Chiara La Rosa, Marco Ghibaudi

et al.

Brain Structure and Function, Journal Year: 2023, Volume and Issue: 229(8), P. 1775 - 1793

Published: Oct. 13, 2023

Neuronal plasticity can vary remarkably in its form and degree across animal species. Adult neurogenesis, namely the capacity to produce new neurons from neural stem cells through adulthood, appears widespread non-mammalian vertebrates, whereas it is reduced mammals. A growing body of comparative studies also report variation occurrence activity cell niches between mammals, with a general trend reduction small-brained large-brained Conversely, recent have shown that mammals host large amounts expressing typical markers neurogenesis absence division. In layer II cerebral cortex, populations prenatally generated, non-dividing continue express molecules indicative immaturity throughout life (cortical immature neurons; cINs). After remaining dormant state for very long time, these cINs retain potential differentiating into mature integrate within preexisting circuits. They are restricted paleocortex rodents, while extending widely expanded neocortex highly gyrencephalic, The current hypothesis non-newly generated "immature" might represent reservoir developmentally plastic mammalian species characterized by cell-driven adult neurogenesis. This indicates there may be trade-off various forms coexist during brain evolution. balance necessary maintain "reservoir plasticity" regions distinct roles species-specific socioecological adaptations, such as olfactory structures.

Language: Английский

Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications DOI
Alexandria Tartt,

Madeline Mariani,

René Hen

et al.

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 27(6), P. 2689 - 2699

Published: March 30, 2022

Language: Английский

Citations

230
Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells DOI Creative Commons
Daniel Franjic, Mario Škarica, Shaojie Ma

et al.

Neuron, Journal Year: 2021, Volume and Issue: 110(3), P. 452 - 469.e14

Published: Nov. 18, 2021

The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To investigate potential cellular diversity, we profiled single-nucleus transcriptomes five subregions humans, macaques, pigs. Integrated cross-species analysis revealed robust transcriptomic histologic signatures of neurogenesis the adult mouse, pig, macaque but not humans. Doublecortin (DCX), a widely accepted marker newly generated granule cells, was detected diverse human neurons, it did define immature neuron populations. explore species differences diversity implications for disease, characterized subregion-specific, transcriptomically defined cell types transitional changes from three-layered archicortex six-layered neocortex. Notably, METTL7B subregion-specific excitatory neurons astrocytes primates, associated with endoplasmic reticulum lipid droplet proteins, including disease-related proteins. This resource reveals cell-type- species-specific properties shaping function.

Language: Английский

Citations

227
Molecular landscapes of human hippocampal immature neurons across lifespan DOI
Yi Zhou, Yijing Su, Shiying Li

et al.

Nature, Journal Year: 2022, Volume and Issue: 607(7919), P. 527 - 533

Published: July 6, 2022

Language: Английский

Citations

209
Neurogenesis in aging and age-related neurodegenerative diseases DOI Creative Commons

Luka Čulig,

Xixia Chu,

Vilhelm A. Bohr

et al.

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 78, P. 101636 - 101636

Published: April 29, 2022

Language: Английский

Citations

117
Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans DOI Open Access
Wei Wang, Mengdi Wang, Meng Yang

et al.

Cell Research, Journal Year: 2022, Volume and Issue: 32(8), P. 729 - 743

Published: June 24, 2022

Language: Английский

Citations

89
The transition to motherhood: linking hormones, brain and behaviour DOI
Camila Servin-Barthet, Magdalena Martínez‐García, Clara Pretus

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(10), P. 605 - 619

Published: Aug. 23, 2023

Language: Английский

Citations

55
Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction DOI Creative Commons
Yi Lü,

Faqian Bu,

Fang Wang

et al.

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: Feb. 27, 2023

Abstract Physical exercise is of great significance for maintaining human health. Exercise can provide varying degrees benefits to cognitive function at all stages life cycle. Currently, with the aging world’s population and increase expectancy, dysfunction has gradually become a disease high incidence, which accompanied by neurodegenerative diseases in elderly individuals. Patients often exhibit memory loss, aphasia weakening orientation once diagnosed, are unable have normal life. Cognitive largely affects physical mental health, reduces quality life, causes economic burden society. At present, most interventions aimed maintain current level delay deterioration cognition. In contrast, as nonpharmacological therapy advantages its nontoxicity, low cost universal application. The molecular mechanisms underlying effect on cognition complex, studies been extensively centered neural plasticity, direct target brain. addition, mitochondrial stability energy metabolism essential brain status. Meanwhile, organ-brain axis responds induces release cytokines related this review, we summarize latest evidence effects cognition, point out directions future research.

Language: Английский

Citations

54
Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: Reconciling controversy or fueling the debate? DOI Creative Commons
Giorgia Tosoni, Dilara Ayyildiz, Julien Bryois

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(11), P. 1714 - 1731.e3

Published: April 3, 2023

The notion of exploiting the regenerative potential human brain in physiological aging or neurological diseases represents a particularly attractive alternative to conventional strategies for enhancing restoring function. However, major first question address is whether does possess ability regenerate. existence adult hippocampal neurogenesis (AHN) has been at center fierce scientific debate many years. advent single-cell transcriptomic technologies was initially viewed as panacea resolving this controversy. recent RNA sequencing studies hippocampus yielded conflicting results. Here, we critically discuss and re-analyze previously published AHN-related datasets. We argue that, although promising, profiling AHN can be confounded by methodological, conceptual, biological factors that need consistently addressed across openly discussed within community.

Language: Английский

Citations

45
Walking and Hippocampal Formation Volume Changes: A Systematic Review DOI Creative Commons

Mohamed Hesham Khalil

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(1), P. 52 - 52

Published: Jan. 8, 2025

Sustaining the human brain's hippocampus from atrophy throughout ageing is critical. Exercise proven to be effective in promoting adaptive hippocampal plasticity, and has a bidirectional relationship with physical environment. Therefore, this systematic review explores effects of walking, simple activity environment, on formation volume changes for lifelong brain cognitive health. PubMed, Scopus, Web Science were searched studies humans published up November 2022 examining walking. Twelve met inclusion criteria. Study quality was assessed using PEDro scale ROBINS-I tool. A narrative synthesis explored walking factors associated total, subregional, hemisphere-specific changes. Overall, had positive volumes. Several found benefits higher-intensity greater amounts total volume. The subiculum increased after low-intensity nature exposure, while parahippocampal gyrus benefited vigorous intensity. right spatial navigation during No examined effect dentate gyrus. This highlights as multifaceted variable that can lead manifold These findings support promotion simple, strategy enhance health prevent decline, suggesting design environments natural biophilic characteristics layouts walkability stimulation. Future research encouraged explore subregional instead focusing volume, since multicompartmental subfields respond differently different walking-related variables.

Language: Английский

Citations

3
Towards Substitution of Hexane as Extraction Solvent of Food Products and Ingredients with No Regrets DOI Creative Commons
Christian Cravotto, Anne‐Sylvie Fabiano‐Tixier, Ombéline Claux

et al.

Foods, Journal Year: 2022, Volume and Issue: 11(21), P. 3412 - 3412

Published: Oct. 28, 2022

Hexane is a solvent used extensively in the food industry for extraction of various products such as vegetable oils, fats, flavours, fragrances, colour additives or other bioactive ingredients. As it classified “processing aid”, does not have to be declared on label under current legislation. Therefore, although traces hexane may found final products, especially processed its presence known consumers. However, hexane, and particular n-hexane isomer, has been shown neurotoxic humans even listed cause occupational diseases several European countries since 1970s. In order support strategy toxic-free environment (and food), seemed important collect scientific information this substance by reviewing available literature. This review contains valuable nature origin applications industry, toxicological evaluation possible alternatives natural products. Numerous publications investigated toxicity studies demonstrated toxic metabolite 2,5-hexanedione (2,5-HD) urine general, non-occupationally exposed population. Surprisingly, tolerable daily intake (TDI) apparently never established any safety authority. Since residues are undoubtedly foods, seems more than necessary clearly assess risks associated with hidden exposure. A clear indication packaging better could encourage switch towards one numerous alternative methods already developed.

Language: Английский

Citations

61