Predictive coding and stochastic resonance as fundamental principles of auditory phantom perception

Brain, Journal Year: 2023, Volume and Issue: 146(12), P. 4809 - 4825

Published: July 27, 2023

Mechanistic insight is achieved only when experiments are employed to test formal or computational models. Furthermore, in analogy lesion studies, phantom perception may serve as a vehicle understand the fundamental processing principles underlying healthy auditory perception. With special focus on tinnitus-as prime example of perception-we review recent work at intersection artificial intelligence, psychology and neuroscience. In particular, we discuss why everyone with tinnitus suffers from (at least hidden) hearing loss, but not loss tinnitus. We argue that intrinsic neural noise generated amplified along pathway compensatory mechanism restore normal based adaptive stochastic resonance. The increase can then be misinterpreted input perceived This formalized Bayesian brain framework, where percept (posterior) assimilates prior prediction (brain's expectations) likelihood (bottom-up signal). A higher mean lower variance (i.e. enhanced precision) shifts posterior, evincing misinterpretation sensory evidence, which further confounded by plastic changes underwrite predictions. Hence, two provide most explanatory power for emergence perceptions: predictive coding top-down resonance complementary bottom-up mechanism. conclude both also play crucial role Finally, context neuroscience-inspired improve contemporary machine learning techniques.

Language: Английский

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Hearing loss and brain plasticity: the hyperactivity phenomenon

Brain Structure and Function, Journal Year: 2021, Volume and Issue: 226(7), P. 2019 - 2039

Published: June 7, 2021

Language: Английский

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Preclinical Efficacy And Safety Evaluation of AAV‐OTOF in DFNB9 Mouse Model And Nonhuman Primate

Advanced Science, Journal Year: 2023, Volume and Issue: 11(3)

Published: Nov. 28, 2023

Abstract OTOF mutations are the principal causes of auditory neuropathy. There reports on Otof ‐related gene therapy in mice, but there is no preclinical research drug evaluations. Here, Anc80L65 and mouse hair cell‐specific Myo15 promoter (mMyo15) used to selectively effectively deliver human cells mice nonhuman primates evaluate efficacy safety drugs. A new dual‐AAV ‐OTOF‐ hybrid strategy transfer full‐length generated, which can stably restore hearing adult p.Q939*/Q939* with profound deafness, longest duration being at least 150 days, best therapeutic effect without difference from wild‐type mice. An AAV microinjection method into cochlea cynomolgus monkeys impairment further established found be safely driven by mMyo15 cells. In addition, dose drugs has impact normal does not cause significant systemic toxicity both primates. summary, this study develops a potential for DFNB9 patients clinic provides complete, standardized, systematic data clinical application.

Language: Английский

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Predictors of Tinnitus Symptom Relief With Hearing Aids in a European Multicenter Study

Ear and Hearing, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Objectives: Hearing aids (HAs) are a widely accepted first-line treatment option for individuals suffering from both hearing loss and chronic tinnitus. Though HAs highly effective at improving speech understanding, their effectiveness in ameliorating tinnitus symptoms is less clear. In recent years, several investigators have reported on attempts to predict using an array of variables. These included attributes (e.g., frequency, loudness, character), audiological characteristics degree configuration loss), or HA signal processing parameters gain, noise reduction processing). The aims this study were determine whether (1) usage improves tinnitus-related distress subjective loudness and, if so, (2) loss, HA-use time, the accuracy fitting influence effect. Design: Participants recruited as part “Unification Treatments Interventions Tinnitus Patients (UNITI)” study, large multicenter randomized controlled trial conducted across five European sites. Here, we report 60 participants with mild-to-moderate that HAs-only arm UNITI. programmed according National Acoustic Laboratories-Nonlinear 2 Desired Sensation Level ((i/o) v.5) prescriptive formulas was verified in-situ verification. Subsequently, underwent 12-week phase. Improvements measured Handicap Inventory (THI) Functional Index (TFI), well (dB HL), assessed after 6 12 weeks treatment. Accuracy operationalized deviation real ear–aided response target parameters, specified by respective formula. Results: Participants’ time averaged 4.8 hr/d (SD 2.4 hr/d) over Multilevel regression analyses revealed significant reductions scores (THI: F (2,156) = 7.80, p < 0.01; TFI: (2,155) 8.79, 0.01) treatment, compared baseline. After usage, THI decreased 11.64 points TFI 12.80 points, average. There no further statistically between M 1.75, 0.89; −1.58, 0.91). Contrary expectations, none factors predicted these effects. Subjective remained unchanged (M 1.90; (1,105) 0.40, 0.53). Conclusions: associated distress—irrespective attributes, characteristics. Future research designs include additional predictors, control groups larger, more heterogeneous samples needed clarify mechanisms change amplification

Language: Английский

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Tinnitus and hyperacusis: central noise, gain and variance

Current Opinion in Physiology, Journal Year: 2020, Volume and Issue: 18, P. 123 - 129

Published: Nov. 13, 2020

Language: Английский

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Development of ebselen for the treatment of sensorineural hearing loss and tinnitus

Hearing Research, Journal Year: 2021, Volume and Issue: 413, P. 108209 - 108209

Published: Feb. 21, 2021

Language: Английский

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What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(3)

Published: Feb. 15, 2024

Abstract The hippocampus and parahippocampal gyrus have been implicated as part of a tinnitus network by number studies. These structures are usually considered in the context “limbic system,” concept typically invoked to explain emotional response tinnitus. Despite this common framing, it is not apparent from current literature that necessarily main functional role these persistent Here, we highlight different encompasses their most commonly position within brain—that is, memory system. We consider an auditory object held memory, which may be made associated activity gyrus. Evidence animal human studies implicating reviewed used anchor for hypothesis. potential hippocampus/parahippocampal facilitate maintenance percept via communication with cortex, rather than (or addition to) mediating responses percept.

Language: Английский

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Disturbed Balance of Inhibitory Signaling Links Hearing Loss and Cognition

Frontiers in Neural Circuits, Journal Year: 2022, Volume and Issue: 15

Published: Jan. 6, 2022

Neuronal hyperexcitability in the central auditory pathway linked to reduced inhibitory activity is associated with numerous forms of hearing loss, including noise damage, age-dependent and deafness, as well tinnitus or processing deficits autism spectrum disorder (ASD). In most cases, accompanying are interpreted an active compensatory response absence synaptic activity, increased neural gain control (increased output relative input). We here suggest that also could be related immaturity impairment tonic strength typically develops activity-dependent process ascending experience. these high-SR nerve fibers, which critical for shortest latencies lowest sound thresholds, may have either not matured (possibly congenital deafness autism) dysfunctional after sudden, stressful trauma loss cognitive decline). Fast can occur despite maintained basal hearing. case, nuclei, fast parvalbumin positive interneuron (PV-IN) dendrites diminished frontal brain regions. This leads hippocampal LTP/LTD deficiencies, deficits, unbalanced extra-hypothalamic stress control. Under conditions, a weaken local neuronal coupling homeostatic vascular responses required metabolic support adjustment processes. emphasize need distinguish two states excitatory/inhibitory imbalance disorders: (i) conditions preserved sustained strength, following deprivation maintain precise through memory linked, transient disinhibition enhanced spiking fidelity (central gain⇑) (ii) critically part synchronization over broader frequency range, reliability gain⇓). latter stage mutually reinforces processes, increasing risks canonical dementia syndromes.

Language: Английский

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Disruptions of default mode network and precuneus connectivity associated with cognitive dysfunctions in tinnitus

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: April 7, 2023

Tinnitus is the perception of a ringing, buzzing or hissing sound "in ear" without external stimulation. Previous research has demonstrated changes in resting-state functional connectivity tinnitus, but findings do not overlap and are even contradictory. Furthermore, how altered tinnitus related to cognitive abilities currently unknown. Here we investigated differences between 20 patients with chronic control participants matched age, sex hearing loss. All underwent magnetic resonance imaging, audiometric assessments, filled questionnaires targeting anxiety depression. Significant were obtained. However, did find significant associations scores coupling default mode network precuneus superior parietal lobule, supramarginal gyrus, orbitofrontal cortex. Further, distress correlated lateral occipital complex. This first study providing evidence for disruptions that dysfunctions tinnitus. The constant attempt decrease sensation might occupy certain brain resources otherwise available concurrent operations.

Language: Английский

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Hyperacusis and Tinnitus

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 501 - 513

Published: Jan. 1, 2024

Language: Английский

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