Neuron, Journal Year: 2017, Volume and Issue: 93(2), P. 299 - 307
Published: Jan. 1, 2017
Language: Английский
eLife, Journal Year: 2016, Volume and Issue: 5
Published: Sept. 26, 2016
Rapid and stable control of pupil size in response to light is critical for vision, but the neural coding mechanisms remain unclear. Here, we investigated basis by monitoring across time while manipulating each photoreceptor input or neurotransmitter output intrinsically photosensitive retinal ganglion cells (ipRGCs), a relay size. We show that transient sustained responses are mediated distinct photoreceptors neurotransmitters. Transient utilize from rod classical glutamate, adapt within minutes. In contrast, dominated non-conventional signaling mechanisms: melanopsin phototransduction ipRGCs neuropeptide PACAP, which provide maintenance day. These results highlight temporal switch circuit support proper behavioral dynamics.
Language: Английский
Citations
104
Neuron, Journal Year: 2017, Volume and Issue: 93(4), P. 914 - 928.e4
Published: Feb. 1, 2017
Language: Английский
Citations
104
Current Biology, Journal Year: 2013, Volume and Issue: 23(17), P. 1696 - 1701
Published: Aug. 15, 2013
Melanopsin-expressing photosensitive retinal ganglion cells (pRGCs) represent a third class of photoreceptor [1Hankins M.W. Peirson S.N. Foster R.G. Melanopsin: an exciting photopigment.Trends Neurosci. 2008; 31: 27-36Abstract Full Text PDF PubMed Scopus (305) Google Scholar, 2Do M.T. Yau K.W. Intrinsically cells.Physiol. Rev. 2010; 90: 1547-1581Crossref (280) 3Hughes S. Hankins Melanopsin phototransduction: slowly emerging from the dark.Prog. Brain Res. 2012; 199: 19-40Crossref (68) Scholar]. These are intrinsically photosensitive, but also receive inputs rod and cone photoreceptors [4Belenky M.A. Smeraski C.A. Provencio I. Sollars P.J. Pickard G.E. bipolar amacrine cell synapses.J. Comp. Neurol. 2003; 460: 380-393Crossref (229) 5Viney T.J. Balint K. Hillier D. Siegert Boldogkoi Z. Enquist L.W. Meister M. Cepko C.L. Roska B. Local circuits melanopsin-containing identified by transsynaptic viral tracing.Curr. Biol. 2007; 17: 981-988Abstract (152) 6Wong K.Y. Dunn F.A. Graham D.M. Berson Synaptic influences on rat ganglion-cell photoreceptors.J. Physiol. 582: 279-296Crossref (203) 7Schmidt T.M. Kofuji P. Differential pathway influence subtypes.J. 30: 16262-16271Crossref (80) Scholar], acting as primary sensory conduit mediating non-image-forming responses to light [8Altimus C.M. Güler A.D. Villa K.L. McNeill D.S. Legates T.A. Hattar Rods-cones melanopsin detect dark modulate sleep independent image formation.Proc. Natl. Acad. Sci. USA. 105: 19998-20003Crossref (197) 9Güler Ecker J.L. Lall G.S. Haq Altimus Liao H.W. Barnard A.R. Cahill H. Badea T.C. Zhao et al.Melanopsin principal conduits for rod-cone input vision.Nature. 453: 102-105Crossref (614) 10Hatori Le Vollmers C. Keding S.R. Tanaka N. Buch T. Waisman A. Schmedt Jegla Panda Inducible ablation melanopsin-expressing reveals their central role in non-image forming visual responses.PLoS ONE. 3: e2451Crossref (217) 11Lucas R.J. Allen A.E. Brown How rod, cone, come together enlighten mammalian circadian clock.Prog. 1-18Crossref (127) Multiple subtypes pRGC have been described mouse retina with characteristic morphologies functional properties, which perform distinct physiological roles [12Chen S.K. Photoentrainment pupillary reflex mediated populations ipRGCs.Nature. 2011; 476: 92-95Crossref (294) 13Estevez M.E. Fogerson P.M. Ilardi M.C. Borghuis B.G. Chan E. Weng Auferkorte O.N. Demb J.B. Form function M4 cell, type contributing geniculocortical vision.J. 32: 13608-13620Crossref (163) 14Schmidt Chen cells: many subtypes, diverse functions.Trends 34: 572-580Abstract (378) 15Schmidt Do Dacey Lucas R. Matynia Melanopsin-positive form function.J. 16094-16101Crossref (170) Here, we examine levels expression distribution across retina, identifying previously unreported anatomical specialization system. Our results show dorsal-ventral gradient pRGCs, which, combined gradients ultraviolet-sensitive medium-wavelength-sensitive opsin expression, produce dramatic variations ratio opsins pRGCs retina. Using c-fos marker activation vivo [16Semo Daniela L. Butler J. Light induced induction young aged rodless/coneless (rd/rd cl) mice.Eur. 18: 3007-3017Crossref (71) 17Pickard Baver S.B. Ogilvie M.D. Light-induced fos knockout (opn4) mice.PLoS 2009; 4: e4984Crossref (27) 18Hannibal Vrang Card J.P. Fahrenkrug Light-dependent cFos during subjective day night PACAP-containing retinohypothalamic tract.J. Rhythms. 2001; 16: 457-470Crossref (58) that spectrally tuned depending location data illustrate importance classical providing spectral tuning important implications complexity light.
Language: Английский
Citations
102
Cell Reports, Journal Year: 2021, Volume and Issue: 35(3), P. 109022 - 109022
Published: April 1, 2021
Age-related macular degeneration and other diseases result in the loss of light-sensing cone photoreceptors, causing irreversible sight impairment. Photoreceptor replacement may restore vision by transplanting healthy cells, which must form new synaptic connections with recipient retina. Despite recent advances, convincing evidence functional connectivity arising from transplanted human photoreceptors advanced retinal is lacking. Here, we show restoration visual function after transplantation purified pluripotent stem cell-derived cones into a mouse model degeneration. Transplanted elaborate nascent outer segments make putative synapses murine bipolar cells (BCs), themselves undergo significant remodeling. Electrophysiological behavioral assessments demonstrate surprisingly complex light-evoked ganglion cell responses improved behaviors treated animals. Stringent controls exclude alternative explanations, including material transfer neuroprotection. These data provide crucial validation for photoreceptor therapy potential to rescue cone-mediated vision.
Language: Английский
Citations
97
Neuron, Journal Year: 2017, Volume and Issue: 93(2), P. 299 - 307
Published: Jan. 1, 2017
Language: Английский
Citations
92