Apolar Extracts of St. John’s Wort Alleviate the Effects of β-Amyloid Toxicity in Early Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1301 - 1301

Published: Jan. 21, 2024

Hypericum perforatum (St. John’s wort) has been described to be beneficial for the treatment of Alzheimer’s disease (AD). Different extractions have demonstrated efficiency in mice and humans, esp. extracts with a low hypericin hyperforin content reduce side effects such as phototoxicity. In order systematically elucidate therapeutic H. different polarities, APP-transgenic were treated total ethanol extract (TE), polar obtained from TE, an apolar supercritical CO2 (scCO2) extract. The scCO2 was formulated silicon dioxide (SiO2) better oral application. several (total, polar, apolar) at concentrations. We established early paradigm age 40 days until 80 days, starting before onset cerebral β-amyloid (Aβ) deposition 45 age. Their on intracerebral soluble insoluble Aβ analyzed using biochemical analyses. Our study confirms that scCO2H. formulation shows biological activity against Aβ-related pathological than TE or extracts. Clinically, resulted dose-dependent improvement food intake augmentation body weight, and, biochemically, it significant reduction both (−27% −25%, respectively). therefore recommend patients mild cognitive impairment AD.

Language: Английский

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p38α Mitogen-Activated Protein Kinase—An Emerging Drug Target for the Treatment of Alzheimer’s Disease

Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4354 - 4354

Published: Sept. 13, 2024

Alzheimer's disease (AD) is a neurodegenerative disorder, characterized by the formation of amyloid β and tau protein aggregates in brain, neuroinflammation, impaired cholinergic neurotransmission, oxidative stress, resulting gradual loss neurons neuronal function, which leads to cognitive memory deficits AD patients. Chronic neuroinflammation plays particularly important role progression since excessive release proinflammatory cytokines from glial cells (microglia astrocytes) induces damage, subsequently causes microglial activation, thus facilitating further changes. Mitogen-activated kinase (MAPK) p38α one key enzymes involved control innate immune response. The increased activation MAPK pathway, observed AD, has been for long time associated not only with maintenance inflammatory process but also linked pathophysiological hallmarks this disease, therefore currently considered an attractive drug target novel therapeutics. This review aims summarize current state knowledge about involvement different aspects pathophysiology provides insight into possible therapeutic effects inhibitors, are studied as potential candidates treatment.

Language: Английский

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Frontiers and hotspots evolution in anti-inflammatory studies for Alzheimer’s disease

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 472, P. 115178 - 115178

Published: Aug. 1, 2024

Language: Английский

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Navigating complexities of racial disparities in Alzheimer disease biomarkers

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(4), P. 205 - 206

Published: Jan. 23, 2024

Language: Английский

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