Neurophysiological mechanisms underlying post-stroke deficits in contralesional perceptual processing DOI Open Access
Daniel J. Pearce,

Ger M. Loughnane,

Trevor T.‐J. Chong

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 13, 2023

Abstract Slowed responding to sensory inputs presented in contralesional space is pervasive following unilateral cerebral stroke, but the causal neurophysiological pathway by which this occurs remains unclear. To end, here we leverage a perceptual decision-making framework disambiguate information processing stages between sensation and action 30 stroke patients (18 right hemisphere, 12 left hemisphere) 27 neurologically healthy adults. By recording neural activity using electroencephalography (EEG) during task performance, show that relationship strokes either hemisphere slowed response times sequentially mediated weaker target selection signals contralateral (the N2c ERP), subsequently delayed evidence accumulation centroparietal positivity). Notably, asymmetries CPP across hemispheres are associated with everyday functioning. Together, these data suggest plausible post-stroke slowing arises highlight utility of assessments for tracking clinically relevant behaviour.

Language: Английский

Modeling the neurocognitive dynamics of language across the lifespan DOI Creative Commons
Clément Guichet, Sonja Banjac, Sophie Achard

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(5)

Published: March 29, 2024

Abstract Healthy aging is associated with a heterogeneous decline across cognitive functions, typically observed between language comprehension and production (LP). Examining resting‐state fMRI neuropsychological data from 628 healthy adults (age 18–88) the CamCAN cohort, we performed state‐of‐the‐art graph theoretical analysis to uncover neural mechanisms underlying this variability. At level, our findings suggest that LP not an isolated function but modulated throughout lifespan by extent of inter‐cognitive synergy semantic domain‐general processes. cerebral show default mode network (DMN) suppression coupled fronto‐parietal (FPN) integration way for brain compensate effects dedifferentiation at minimal cost, efficiently mitigating age‐related in LP. Relatedly, reduced DMN midlife could compromise ability manage cost FPN integration. This may prompt older adopt more cost‐efficient compensatory strategy maintains global homeostasis expense performances. Taken together, propose represents critical neurocognitive juncture signifies onset decline, as gradually lose control over representations. We summarize novel synergistic, economical, nonlinear, emergent, model, integrating connectomic dimensions within complex system perspective.

Language: Английский

Citations

4
Dynamics of White Matter Architecture in Lexical Production among Middle-Aged Adults DOI Creative Commons
Clément Guichet, Élise Roger, Arnaud Attyé

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 9, 2024

Abstract This study aimed to elucidate the white matter changes associated with lexical production (LP) difficulties that typically emerge in middle age, resulting increased naming latencies. To delay onset of LP decline, middle-aged adults may rely on domain-general (DG) and language-specific (LS) compensatory mechanisms as proposed by LARA model (Lexical Access Retrieval Aging). However, our knowledge supporting these remains incomplete. Based a sample 155 from CAMCAN cohort, we combined dimensionality reduction techniques multivariate statistical methods jointly examine relationships between diffusion-weighted imaging LP-related neuropsychological data. Our findings (i) show midlife constitutes pivotal period marked discontinuity brain structure within distributed networks dorsal, ventral, anterior cortico-subcortical pathways, (ii) reveal this signals neurocognitive transition around age 53-54, marking decline. Indeed, results propose initially adopt “semantic strategy” compensate for initial challenges. Still, strategy be compromised when late (age 55-60) lose ability exert cognitive control over semantic representations (i.e., reduced control). In summary, advances comprehension underpin profile age. Specifically, underscore importance considering interplay DG LS processes studying trajectory performance healthy aging. Furthermore, offer valuable insights into identifying predictive biomarkers related dynamics observed midlife, which can help understand language-related neurodegenerative pathologies. Highlights Midlife characterized structure. Early 45-55) facilitate access sustain performances. Late gradually representations,

Language: Английский

Citations

1
Underlying Mechanisms of the Protective Effects of Lifestyle Factors in the Prevention of Age-Related Diseases DOI
Nicolás Alcaraz, Pamela Salcedo‐Tello, Rodrigo González‐Barrios

et al.

Archives of Medical Research, Journal Year: 2024, Volume and Issue: 55(5), P. 103014 - 103014

Published: June 12, 2024

Language: Английский

Citations

1
Midlife Dynamics of White Matter Architecture in Lexical Production DOI Creative Commons
Clément Guichet, Élise Roger, Arnaud Attyé

et al.

Neurobiology of Aging, Journal Year: 2024, Volume and Issue: 144, P. 138 - 152

Published: Sept. 28, 2024

Language: Английский

Citations

0
Brain reserve in hepatic encephalopathy: pathways of damage and preventive strategies through lifestyle and therapeutic interventions DOI Creative Commons
Jacqueline Córdova‐Gallardo,

Andres Manuel Vargas-Beltran,

Samantha Melanie Armendariz-Pineda

et al.

Annals of Hepatology, Journal Year: 2024, Volume and Issue: unknown, P. 101740 - 101740

Published: Nov. 1, 2024

Language: Английский

Citations

0
Neurophysiological mechanisms underlying post-stroke deficits in contralesional perceptual processing DOI Open Access
Daniel J. Pearce,

Ger M. Loughnane,

Trevor T.‐J. Chong

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 13, 2023

Abstract Slowed responding to sensory inputs presented in contralesional space is pervasive following unilateral cerebral stroke, but the causal neurophysiological pathway by which this occurs remains unclear. To end, here we leverage a perceptual decision-making framework disambiguate information processing stages between sensation and action 30 stroke patients (18 right hemisphere, 12 left hemisphere) 27 neurologically healthy adults. By recording neural activity using electroencephalography (EEG) during task performance, show that relationship strokes either hemisphere slowed response times sequentially mediated weaker target selection signals contralateral (the N2c ERP), subsequently delayed evidence accumulation centroparietal positivity). Notably, asymmetries CPP across hemispheres are associated with everyday functioning. Together, these data suggest plausible post-stroke slowing arises highlight utility of assessments for tracking clinically relevant behaviour.

Language: Английский

Citations

0