The neural bases for timing of durations

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(11), P. 646 - 665

Published: Sept. 12, 2022

Language: Английский

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Diffusion property and functional connectivity of superior longitudinal fasciculus underpin human metacognition

Neuropsychologia, Journal Year: 2021, Volume and Issue: 156, P. 107847 - 107847

Published: April 1, 2021

Language: Английский

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Specialization for different memory dimensions in brain activity evoked by cued recollection

NeuroImage, Journal Year: 2025, Volume and Issue: 308, P. 121068 - 121068

Published: Jan. 29, 2025

Cued recollection involves the retrieval of different features encoded event. Previous research has shown that complex events jointly recruits Default Mode and Frontoparietal Control networks, but degree to which activity within these networks varies as a function particular memory dimension (e.g., "when-what-where" information) remains largely unknown. In present functional Magnetic Resonance Imaging (fMRI) study, human participants retrieved specific information about previously TV show assess veracity detailed sentences along four dimensions (i.e., object character details, spatial layouts, temporal sequences, verbal dialogues). A common for all was observed in left-lateralized network regions overlaps with Network (FPCN), including lateral prefrontal, superior parietal, cortex. Instead, larger specialization (DMN), particularly its posterior nodes. Dimension-related specificity both associated performance across subjects. Finally, clear leftward asymmetry DMN except one, whereas FPCN showed bilateral activation dimensions. The results generally support view is processed by mosaic large portions associative cortex involved higher-order mnemonic functions.

Language: Английский

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Brain Coding of Social Network Structure

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(22), P. 4897 - 4909

Published: April 26, 2021

Humans have large social networks, with hundreds of interacting individuals. How does the brain represent complex connectivity structure these networks? Here we used media (Facebook) data to objectively map participants' real-life networks. We then representational similarity analysis (RSA) functional magnetic resonance imaging (fMRI) activity patterns investigate neural coding networks as participants reflected on each individual. found network distances in default-mode (medial prefrontal, medial parietal, and lateral parietal cortices). When using partial correlation RSA control for other factors that can be correlated distance (personal affiliation, personality traits. visual appearance, subjectively rated by participants), information was uniquely coded retrosplenial complex, a region involved spatial processing. In contrast, individuals' personal affiliation traits prefrontal cortices, respectively. These findings demonstrate cortical division between representations non-self-referenced (allocentric) structure, self-referenced (egocentric) distance, trait-based knowledge. SIGNIFICANCE STATEMENT Each us has composed individuals, different characteristics relations among them. our this complexity? To find out, mapped connections Facebook asked them think about individuals from their while undergoing MRI scanning. position within network, well participant, are Individuals' were another region, cortex. Our dissociation aspects knowledge suggest link cognitive mapping.

Language: Английский

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Hippocampal orchestration of associative and sequential memory networks for episodic retrieval

Cell Reports, Journal Year: 2023, Volume and Issue: 42(8), P. 112989 - 112989

Published: Aug. 1, 2023

Episodic memory involves the recollection of contextual details replayed mentally across time. Here, we propose association-sequence network (ASN) model, characterizing complementary cortico-hippocampal networks underlying retrieval simultaneously associated and sequentially ordered events. Participants viewed objects, presented singly or in pairs, later reported whether two objects were shown simultaneously, consecutively, farther apart Behavioral results hippocampal activation reveal a correlation between sequential conditions but not simultaneous condition, despite temporal proximity consecutive pairs. We also find that anterior activity is modulated by distance. Distinct cortical are engaged during (prefrontal cortex angular gyrus for association; supplementary motor precuneus sequence); notably, these regions show differential connectivity with hippocampus. The ASN model provides comprehensive framework how reconstruct memories both rich associative detail temporally dynamic nature.

Language: Английский

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Minor Changes Change Memories: Functional Magnetic Resonance Imaging and Behavioral Reflections of Episodic Prediction Errors

Journal of Cognitive Neuroscience, Journal Year: 2023, Volume and Issue: 35(11), P. 1823 - 1845

Published: Jan. 1, 2023

Episodic memories can be modified, a process that is potentially driven by mnemonic prediction errors. In the present study, we used modified cues to induce errors of different episodic relevance. Participants encoded episodes in form short toy stories and then returned for an fMRI session on subsequent day. Here, participants were presented either original or slightly versions thereof. Modifications consisted replacing single object within episode challenged gist (gist modifications) left it intact (surface modifications). On next day, completed post-fMRI memory test probed originally episodes. Both types modifications triggered brain activation regions previously found involved processing content-based (i.e., exchange object). Specifically, these ventrolateral pFC, intraparietal cortex, lateral occipitotemporal cortex. addition, pronounced responses, whereas those surface modification only significant right inferior frontal sulcus. Processing also posterior temporal cortex precuneus. Interestingly, our findings confirmed hippocampal role detail memory, as evidenced increased activity compared with modifications. test, previous experience but not gist-modified episodes, erroneous acceptance same encoded. Whereas surface-level might increase uncertainty facilitate confusion alternative representations, gist-level seem trigger clear distinction independent

Language: Английский

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Components of Mnemonic Metacognition Constitutionally Supported by High Gamma Activity Between the Precuneus and Hippocampus

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 28, 2024

ABSTRACT Metacognition, the ability to introspectively monitor one’s own performance, remains an area with poorly understood neural mechanisms, particularly regarding intercommunication among various brain regions. Recent studies have identified precuneus as a key region in mnemonic metacognitive tasks, while hippocampus is recognized for its role memory function. This study aimed investigate of and metacognition by utilizing intracranial electrode recordings from patients intractable epilepsy analyze correlational dynamics between these Our findings revealed that high gamma activity serve feature both confidence judgment. Based on signal detection theory (SDT), we discovered significantly linked type 2 sensitivity (meta-d’), hippocampal was primarily 1 (d’). Additionally, correlation exclusively related (meta-d’). Temporal analysis indicated initially engaged process, followed joint engagement together generation. These elucidate distinct electrophysiological roles metacognition, providing deeper insights into mechanisms underlying this cognitive process.

Language: Английский

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The influence of the precuneus on the medial temporal cortex determines the subjective quality of memory during the retrieval of naturalistic episodes

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 4, 2024

Memory retrieval entails dynamic interactions between the medial temporal lobe and areas in parietal frontal cortices. Here, we tested hypothesis that effective connectivity precuneus, cortex, cortex contributes to subjective quality of remembering objects together with information about their rich spatio-temporal encoding context. During a 45 min session, participants were presented pictures while they actively explored virtual town. The following day, under fMRI, images had report whether: recognized object could remember place/time encoding, was familiar only, or new. hippocampus/parahippocampus, precuneus ventro-medial prefrontal activated when successfully seen town reported these events. Analyses showed influence exerted by on mediates this effect episodic recollection. Our findings demonstrate role inter-regional mediating experience underline relevance studying memory contextually-rich conditions.

Language: Английский

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Neural signatures for temporal-order memory in the medial posterior parietal cortex

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 18, 2023

Episodic memory involves encoding and remembering the order of events experienced over time. Previous work examining mechanisms temporal-order memories has focused on hippocampus prefrontal cortices but largely ignored ensembles in medial posterior parietal cortex (mPPC). Combining vivo multi-unit electrophysiology a judgment task with cinematic material macaque, we find that mPPC neuronal activity reflects temporal context both during recall. During learning, encode information as well contextual embedded videos, whereas at retrieval these neurons fire synchrony prior to memory-guided decisions. Moreover, similarity between correlates animals performance. A control experiment further ruled out eye saccades, fixation, scan path for their confounding roles neural results. Together, data suggest track passage time changes, thereby orchestrating successful retrieval.

Language: Английский

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Hippocampal Representations of Event Structure and Temporal Context during Episodic Temporal Order Memory

Cerebral Cortex, Journal Year: 2021, Volume and Issue: 32(7), P. 1520 - 1534

Published: Aug. 4, 2021

The hippocampus plays an important role in representing spatial locations and sequences transforming representations. How these representational structures operations support memory for the temporal order of random items is still poorly understood. We addressed this question by leveraging method loci, a powerful mnemonic strategy that particularly recruits hippocampus-dependent computations associations. Applying similarity analysis to functional magnetic resonance imaging activation patterns revealed hippocampal subfields contained representations multiple features sequence structure, including locations, location distance, boundaries, as well episodic-like context. Critically, CA1 exhibited transformation patterns, showing lower pattern same than closely matched different during retrieval, whereas CA23DG sequential near far encoding. These transformations enabled encoding disambiguation adjacent items. Our results suggest can flexibly reconfigure multiplexed event structure accurate memory.

Language: Английский

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