Cited by The role of circRNAs and miRNAs in drug resistance and targeted therapy responses in breast cancer

Interactions between circRNA and protein in breast cancer DOI

Bin Yang,

Ya‐Wen Wang,

Kai Zhang

et al.

Gene, Journal Year: 2023, Volume and Issue: 895, P. 148019 - 148019

Published: Nov. 19, 2023

Language: Английский

Citations

circRNA-SFMBT2 orchestrates ERα activation to drive tamoxifen resistance in breast cancer cells DOI

Zheng Li, Yaming Li,

Dianwen Han

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(7)

Published: July 31, 2023

Abstract Dysregulated ERα signaling is responsible for endocrine resistance and eventual relapse in patients with estrogen receptor-positive (ER + ) breast cancer. Thus, identifying novel regulators necessary to fully understand the mechanisms of resistance. Here, we identified circRNA-SFMBT2 be highly expressed ER cancer cells comparison − found that high levels were related larger tumor size poor prognosis In vitro vivo experiments confirmed level was positively correlated protein level, implying a regulatory role signaling. Moreover, biogenesis could facilitated via RNA-binding quaking (QKI), biologically elevated expression promoted cell growth tamoxifen Mechanistically, exhibits specific tertiary structure endows it binding affinity allows interact AF2 DBD domains ERα, enforcing recruitment RNF181 AF1 domain ERα. Furthermore, circRNA-SFMBT2/RNF181 axis differentially regulated K48-linked K63-linked ubiquitination enhance stability, resulting increased target genes progression. summary, an important regulator signaling, antagonizing may constitute potential therapeutic strategy

Language: Английский

Citations

Overcoming cancer drug-resistance calls for novel strategies targeting abnormal alternative splicing DOI

Ji Zhang,

Xinyu Xu, Hong‐Wei Deng

et al.

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 261, P. 108697 - 108697

Published: July 23, 2024

Language: Английский

Citations

CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA DOI

Chunyu Zhang, Yuan Li,

Qiaojian Zou

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: Feb. 8, 2024

Abstract Background Cervical cancer (CCa) is the fourth most common among females, with high incidence and mortality rates. Circular RNAs (circRNAs) are key regulators of various biological processes in cancer. However, role circRNAs cervical remains largely unknown. This study aimed to elucidate circMAST1 CCa. Methods CircRNAs related CCa progression were identified via a circRNA microarray. The relationship between levels clinicopathological features was evaluated using clinical specimens data 131 patients In vivo vitro experiments, including xenograft animal models, cell proliferation assay, transwell RNA pull-down whole-transcriptome sequencing, RIP RNA-FISH, performed investigate effects on malignant behavior Results CircMAST1 significantly downregulated tissues, low expression correlated poor prognosis. Moreover, our results demonstrated that inhibited tumor growth lymph node metastasis Mechanistically, competitively sequestered N-acetyltransferase 10 (NAT10) hindered Yes-associated protein (YAP) mRNA ac4C modification promote its degradation inhibit Conclusions plays major suppressive particular, can serve as potential biomarker novel target for

Language: Английский

Citations

Hsa_circ_0007990 promotes breast cancer growth via inhibiting YBX1 protein degradation to activate E2F1 transcription DOI

Tao Xu,

Mengqiu Xiong,

Qiwei Hong

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(2)

Published: Feb. 20, 2024

Abstract Breast cancer (BC) is the most commonly diagnosed malignant tumour in females worldwide. Although remarkable advances early detection and treatment strategies have led to decreased mortality, recurrence metastasis remain major causes of death BC patients. Increasing evidence has demonstrated that circular RNAs (circRNAs) play critical roles progression. However, detailed biological functions molecular mechanisms circRNAs are unclear. The aim this study was investigate possible role progression BC. Differentially expressed were identified by integrating breast tumour-associated somatic CNV data circRNA high-throughput sequencing. Aberrant hsa_circ_0007990 expression host gene copy number detected cell lines via quantitative polymerase chain reaction (qPCR). level tissues validated situ hybridization (ISH). Loss- gain-of-function experiments performed vitro vivo, respectively, explore potential function underlying investigated through MS2 RNA pull-down, immunoprecipitation, fluorescence hybridization, immunofluorescence, chromatin immunoprecipitation luciferase reporter assays. levels elevated lines, an effect partly due gains. Functional assays showed promoted growth. Mechanistically, could bind YBX1 inhibit its degradation preventing ubiquitin/proteasome-dependent degradation, thus enhancing cycle-associated E2F1. Rescue suggested YBX1. In general, our modulates ubiquitination protein further regulates E2F1 promote We explored mechanism a novel candidate target for

Language: Английский

Citations

A circRNA–mRNA pairing mechanism regulates tumor growth and endocrine therapy resistance in ER-positive breast cancer DOI

Yi Jia,

Jiao Du,

Xue Chen

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(8)

Published: Feb. 18, 2025

The molecular mechanisms underlying estrogen receptor (ER)-positive breast carcinogenesis and drug resistance remain incompletely understood. Elevated expression of CCND1 is linked to enhanced invasiveness, poorer prognosis, therapies in ER-positive cancer. In this study, we identify a highly expressed circular RNA (circRNA) derived from FOXK2, called circFOXK2, which plays key role stabilizing mRNA, thereby promoting cell cycle progression, growth, endocrine therapy cancer cells. Mechanistically, circFOXK2 binds directly mRNA via RNA-RNA pairing recruits the RNA-binding protein ELAVL1/HuR, enhancing levels. This results activation CCND1-CDK4/6-p-RB-E2F signaling axis, driving transcription downstream E2F target genes facilitating G1/S transition during progression. Notably, targeting with antisense oligonucleotide (ASO-circFOXK2) suppresses growth both vitro vivo. Moreover, combination ASO-circFOXK2 tamoxifen exhibits synergistic effects restores sensitivity tamoxifen-resistant Clinically, high positively correlated levels lines patient tumor tissues. Overall, our findings reveal critical oncogene positioning as potential therapeutic for clinical settings.

Language: Английский

Citations

Extracellular vesicle-mediated chemoresistance in breast cancer: focus on miRNA cargo DOI

Maria Chiara Ciferri, Roberta Tasso

Extracellular Vesicles and Circulating Nucleic Acids, Journal Year: 2025, Volume and Issue: 6(1), P. 112 - 27

Published: Feb. 24, 2025

The role of extracellular vesicles (EVs) in mediating chemoresistance has gained significant attention due to their ability transfer bioactive molecules between drug-resistant and drug-sensitive cells. In particular, they have been demonstrated play an active part breast cancer by the horizontal genetic protein material. This review highlights EVs, particularly miRNA cargo, driving drug resistance cancer. EVs derived from chemoresistant cells carry miRNAs lncRNAs, which are known modulate gene networks involved cell proliferation survival. These cargo suppress apoptosis targeting pro-apoptotic genes like PTEN BIM, promote epithelial-mesenchymal transition (EMT) through regulation pathways such as TGF-β Wnt/b-catenin, contribute tumor growth enhancing angiogenesis modulating microenvironment. Beyond RNA-mediated effects, also functional proteins, including P-glycoprotein Hsp70, impact cellular metabolism survival pathways. Our findings underscore significance chemoresistance, suggesting potential involvement possible prognostic factors predict therapy response therapeutic targets combination with usual therapy.

Language: Английский

Citations

Mechanisms of Plant Secondary Metabolites in Antitumor Activity: Insights into circRNA Modulation DOI

Tatiane Roquete Amparo, Tamires Cunha Almeida, Lucas Resende Dutra Sousa

et al.

Reference series in phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 28

Published: Jan. 1, 2025

Language: Английский

Citations

Inhibitory effects of nimodipine, nitrendipine and felodipine on tamoxifen metabolism and molecular docking DOI

Xiaohai Chen,

Fengsheng Hong,

Yuxin Shen

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 236, P. 116854 - 116854

Published: March 5, 2025

Language: Английский

Citations

Circular RNAs as Biomarkers in Breast Cancer Diagnosis, Prognosis, Molecular Types, Metastasis and Drug Resistance DOI

Lixin Li,

Y. Hao,

Lei Dong

et al.

Technology in Cancer Research & Treatment, Journal Year: 2025, Volume and Issue: 24

Published: March 1, 2025

Breast cancer is one of the leading causes cancer-related deaths in women worldwide. Circular RNAs (circRNAs), a novel class endogenous noncoding RNA with covalently closed continuous loop that lacks 5′-cap structure and 3′-poly A tail, are more stable than linear less susceptible to degradation by nucleases. CircRNAs widespread multiple mammalian genomes have been detected various tissues, cells body fluids. Increasing evidence shows abnormal expression circRNAs involved development variety diseases, including breast cancer. Numerous studies explored potential as biomarkers malignant tumors. In this review, we aim provide comprehensive overview latest advances promising early diagnosis, prognosis, molecular type, metastasis drug resistance

Language: Английский

Citations