Antibiotic resistance and persistence—Implications for human health and treatment perspectives

EMBO Reports, Journal Year: 2020, Volume and Issue: 21(12)

Published: Dec. 3, 2020

Language: Английский

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Skeletal infections: microbial pathogenesis, immunity and clinical management

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 20(7), P. 385 - 400

Published: Feb. 15, 2022

Language: Английский

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Economic significance of biofilms: a multidisciplinary and cross-sectoral challenge

npj Biofilms and Microbiomes, Journal Year: 2022, Volume and Issue: 8(1)

Published: May 26, 2022

Abstract The increasing awareness of the significance microbial biofilms across different sectors is continuously revealing new areas opportunity in development innovative technologies translational research, which can address their detrimental effects, as well exploit benefits. Due to extent affected by biofilms, capturing real financial impact has been difficult. This perspective highlights this globally, based on figures identified a recent in-depth market analysis commissioned UK’s National Biofilms Innovation Centre (NBIC). outputs from and workshops organised NBIC its research strategic themes have revealed breath opportunities for biofilms. However, there are still many outstanding scientific technological challenges must be addressed order catalyse these opportunities. discusses some challenges.

Language: Английский

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Ribosome biogenesis in disease: new players and therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Jan. 9, 2023

Abstract The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis the process generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, transformation. mTORC1, Myc, noncoding RNA signaling pathways are primary mediators work jointly with polymerases proteins to control protein synthesis. Activation of mTORC1 required for normal fetal growth development tissue regeneration after birth. Myc implicated cancer by enhancing Pol II activity, leading uncontrolled growth. deregulation RNAs such as microRNAs, long RNAs, circular involved developing blood, neurodegenerative diseases, atherosclerosis. We review similarities differences between eukaryotic bacterial molecular mechanism ribosome-targeting antibiotics resistance. also most recent findings dysfunction COVID-19 other conditions discuss consequences frameshifting, ribosome-stalling, ribosome-collision. summarize various diseases. Furthermore, we current clinical trials, prospective vaccines COVID-19, therapies targeting cancer, cardiovascular disease, aging, disease.

Language: Английский

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Tackling antimicrobial resistance across sub-Saharan Africa: current challenges and implications for the future

Expert Opinion on Drug Safety, Journal Year: 2022, Volume and Issue: 21(8), P. 1089 - 1111

Published: July 23, 2022

Introduction Antimicrobial resistance (AMR) is a concern as this increases morbidity, mortality, and costs, with sub-Saharan Africa having the highest rates globally. Concerns rising AMR have resulted in international, Pan-African, country activities including development of national action plans (NAPs). However, there variable implementation across key challenges persisting.Areas covered Consequently, an urgent need to document current NAP provide future guidance. This builds on narrative review literature.Expert Opinion All surveyed African countries developed their NAPs; however, implementation. Countries Botswana Namibia are yet officially launch NAPs Eswatini only recently launching its NAP. Cameroon further ahead than these countries; though concerns South appears made greatest strides implementing regular monitoring instigation antimicrobial stewardship programs. Key remain Africa. These include available personnel, expertise, capacity, resources undertake agreed active surveillance, lack focal points drive NAPs, competing demands priorities among donors. being addressed, co-ordinated efforts needed reduce AMR.

Language: Английский

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Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Sept. 23, 2022

Drug resistant tuberculosis contributes significantly to the global burden of antimicrobial resistance, often consuming a large proportion healthcare budget and associated resources in many endemic countries. The rapid emergence resistance newer therapies signals need ensure appropriate antibiotic stewardship, together with concerted drive develop new regimens that are active against currently circulating drug strains. Herein, we highlight current is driven by combination ongoing transmission intra-patient evolution through several mechanisms. Global control will require interventions effectively address these related aspects. Interrupting dependent on availability novel diagnostics which provide accurate results, as near-patient possible, linkage care. Contact tracing, longitudinal follow-up for symptoms mapping social contacts essential elements curb further community-wide spread Appropriate prophylaxis index cases imperative limit disease progression subsequent transmission. Preventing strains development shorter rapidly eliminate all populations mycobacteria, whilst concurrently limiting bacterial metabolic processes tolerance, mutagenesis ultimate resistance. discovery programs specifically target genetic determinants be paramount eradication. In addition, clinical endpoints quantify tolerant organisms sputum, such differentially culturable/detectable tubercle bacteria necessary accurately assess potential shorten treatment duration. When combined, this holistic approach addressing critical problems support delivery quality care patients suffering from bolster efforts eradicate disease.

Language: Английский

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The Therapeutic Wound Healing Bioactivities of Various Medicinal Plants

Life, Journal Year: 2023, Volume and Issue: 13(2), P. 317 - 317

Published: Jan. 23, 2023

The skin serves as the body's first line of defense, guarding against mechanical, chemical, and thermal damage to interior organs. It includes a highly developed immune response that barrier pathogenic infections. Wound healing is dynamic process underpinned by numerous cellular activities, including homeostasis, inflammation, proliferation, remodeling, require proper harmonious integration effectively repair damaged tissue. Following cutaneous damage, microorganisms can quickly enter tissues beneath skin, which result in chronic wounds fatal Natural phytomedicines possess considerable pharmacological properties have been widely employed forwound treatment infection prevention. Since ancient times, phytotherapy has able efficiently treat wounds, reduce onset infections, minimize usage antibiotics cause critical antibiotic resistance. There are remarkable number wound-healing botanicals used Northern Hemisphere, Achiella millefolium, Aloe vera, Althaea officinalis, Calendula Matricaria chamomilla, Curcuma longa, Eucalyptus, Jojoba, plantain, pine, green tea, pomegranate, Inula. This review addresses most often medicinal plants from Hemisphere facilitate also suggests viable natural alternatives be field wound care.

Language: Английский

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Naringenin: A flavanone with anti-inflammatory and anti-infective properties

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114990 - 114990

Published: June 12, 2023

Although a growing body of research has recently shown how crucial inflammation and infection are to all major diseases, several the medications currently available on market have various unfavourable side effects, necessitating development alternative therapeutic choices. Researchers increasingly interested in or active components derived from natural sources. Naringenin is commonly consumed flavonoid found many plants, since it was discovered nutritional benefits, been utilized treat infections caused by particular bacteria viruses. However, absence adequate clinical data naringenin's poor solubility stability severely restrict its usage as medicinal agent. In this article, we discuss effects mechanisms action autoimmune-induced inflammation, bacterial infections, viral based recent research. We also present few suggestions for enhancing solubility, stability, bioavailability. This paper emphasizes potential use naringenin an anti-inflammatory anti-infective agent next prophylactic substance treatment inflammatory infectious even though some still unclear, offers theoretical support application.

Language: Английский

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Bacterial persisters: molecular mechanisms and therapeutic development

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 17, 2024

Abstract Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing) bacteria that survive in stress environments such as antibiotic exposure, acidic and starvation conditions. These cells can regrow after removal remain the same stress. are underlying problems of treating chronic persistent infections relapse treatment, resistance development, biofilm infections, pose significant challenges for effective treatments. Understanding characteristics exact mechanisms persister formation, especially key molecules affect formation survival persisters is critical more treatment infections. Currently, genes related being discovered confirmed, but by which form very complex, there still many unanswered questions. This article comprehensively summarizes historical background bacterial persisters, details their complex relationship with tolerant resistant bacteria, systematically elucidates interplay between various biological processes cells, well consolidates diverse anti-persister compounds We hope provide theoretical in-depth research on suggest new ideas choosing strategies

Language: Английский

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Bioinspired silver nanoparticle-based nanocomposites for effective control of plant pathogens: A review

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 908, P. 168318 - 168318

Published: Nov. 11, 2023

Language: Английский

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