Unravelling the transcriptomic symphony of muscle ageing: key pathways and hub genes altered by ageing and caloric restriction in rat muscle revealed by RNA sequencing DOI Creative Commons

Gulam Altab,

Brian J. Merry,

Charles W. Beckett

et al.

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 13, 2025

Abstract Age-related muscle wasting, sarcopenia is an extensive loss of mass and strength with age a major cause disability accidents in the elderly. Mechanisms purported to be involved ageing are numerous but poorly understood, necessitating deeper study. Hence, we employed high-throughput RNA sequencing survey global changes protein-coding gene expression occurring skeletal age. Caloric restriction (CR) known prophylactic intervention against sarcopenia. Therefore, total was isolated from tissue both rats fed ad libitum CR rats. RNA-seq data were subjected Gene Ontology, pathway, co-expression, interaction network analyses. This revealed functional pathways most activated by CR, as well key “hub” proteins their activation. 442 genes upregulated 377 downregulated aged muscle, compared young muscle. Upregulated commonly protein folding immune responses; meanwhile, often related developmental biology. found suppress 69.7% rescue 57.8% respectively. In addition, uniquely 291 304 genes. Hub implicated included Gc , Plg Irf7 Ifit3 Usp18 Rsad2 Blm RT1-A2 whilst those exclusively responses Alb Apoa1 Ambp F2 Apoh Orm1 Mx1 Oasl2 Rtp4 . unaffected Fgg Fga Fgb Serpinc1 conclusion, this comprehensive study highlights patterns, hub signalling affected may provide initial evidence for several targets potential future therapeutic interventions

Language: Английский

The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function DOI
Yihang Zhao, Mengzhen Jia, Weixuan Chen

et al.

Free Radical Biology and Medicine, Journal Year: 2022, Volume and Issue: 182, P. 206 - 218

Published: Feb. 24, 2022

Language: Английский

Citations

52
Fasting: From Physiology to Pathology DOI Creative Commons
Dongmei Tang,

Qiuyan Tang,

Wei Huang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(9)

Published: Feb. 3, 2023

Overnutrition is a risk factor for various human diseases, including neurodegenerative metabolic disorders, and cancers. Therefore, targeting overnutrition represents simple but attractive strategy the treatment of these increasing public health threats. Fasting as dietary intervention combating has been extensively studied. practiced millennia, only recently have its roles in molecular clock, gut microbiome, tissue homeostasis function emerged. can slow aging most species protect against These centuried unfading adventures explorations suggest that fasting potential to delay help prevent treat diseases while minimizing side effects caused by chronic interventions. In this review, recent animal studies concerning role underlying mechanism physiology pathology are summarized, therapeutic highlighted, combination pharmacological discussed new regimen diseases.

Language: Английский

Citations

44
Fasting and fasting mimicking diets in cancer prevention and therapy DOI Creative Commons
Olga Blaževitš, Maira Di Tano, Valter D. Longo

et al.

Trends in cancer, Journal Year: 2023, Volume and Issue: 9(3), P. 212 - 222

Published: Jan. 14, 2023

Language: Английский

Citations

36
Intermittent fasting interventions to leverage metabolic and circadian mechanisms for cancer treatment and supportive care outcomes DOI Open Access
Faiza Kalam, Dara James, Leslie A. Lange

et al.

JNCI Monographs, Journal Year: 2023, Volume and Issue: 2023(61), P. 84 - 103

Published: May 4, 2023

Abstract Intermittent fasting entails restricting food intake during specific times of day, days the week, religious practice, or surrounding clinically important events. Herein, metabolic and circadian rhythm mechanisms underlying proposed benefits intermittent for cancer population are described. We summarize epidemiological, preclinical, clinical studies in published between January 2020 August 2022 propose avenues future research. An outstanding concern regarding use among patients is that often results caloric restriction, which can put already prone to malnutrition, cachexia, sarcopenia at risk. Although trials do not yet provide sufficient data support general this summary may be useful patients, caregivers, clinicians who exploring as part their journey outcomes symptom management.

Language: Английский

Citations

28
Systemic proteome adaptions to 7-day complete caloric restriction in humans DOI
Maik Pietzner, Burulça Uluvar, Kristoffer J. Kolnes

et al.

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(4), P. 764 - 777

Published: March 1, 2024

Language: Английский

Citations

16
Vascular dementia: From pathobiology to emerging perspectives DOI Creative Commons
A. Morgan, Mark T. Mc Auley

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102278 - 102278

Published: March 19, 2024

Vascular dementia (VaD) is the second most common type of dementia. VaD synonymous with ageing, and its symptoms place a significant burden on health wellbeing older people. Despite identification substantial number risk factors for VaD, pathological mechanisms underpinning this disease remain to be fully elucidated. Consequently, biogerontological imperative exists highlight modifiable lifestyle which can mitigate against developing VaD. This review will critically examine some have been revealed modulate risk. The survey commences by providing an overview putative are associated pathobiology Next, influence examined. Finally, emerging treatment avenues including epigenetics, gut microbiome, pro-longevity pharmaceuticals discussed. By drawing key evidence together, it our hope that used inform future experimental investigations in field.

Language: Английский

Citations

15
The impact of intermittent fasting on gut microbiota: a systematic review of human studies DOI Creative Commons
Isa Paukkonen,

Elli-Noora Törrönen,

Johnson Lok

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 12, 2024

Background Intermittent fasting (IF) has gained popularity in interventions targeting overweight, obesity and metabolic syndrome. IF may affect the gut microbiome composition therefore have various effects on mediated functions humans. Research of human is limited. Therefore, objective this systematic review was to determine how different types microbiome. Methods A literature search conducted for studies investigating association microbiota richness, alpha beta diversity, subjects. Databases included Cochrane Library (RRID:SCR_013000), PubMed (RRID:SCR_004846), Scopus (RRID:SCR_022559) Web Science (RRID:SCR_022706). total 1,332 were retrieved, which 940 remained after removing duplicates. Ultimately, a 8 review. The randomized controlled trials, quasi-experimental pilot implementing an intervention (time-restricted eating, alternate day or 5:2 diet) healthy subjects with any disease. Results Most found between diversity compositional changes. There heterogeneity results, bacteria be statistically significantly affected by varied widely depending study. Conclusion findings suggest that influences microbiota. It seems possible can improve richness diversity. Due substantial more research required validate these clarify whether changes might beneficial health. Systematic Review Registration https://www.crd.york.ac.uk/prospero/ , identifier CRD42021241619.

Language: Английский

Citations

13
Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding DOI Creative Commons
Ashley S. Williams, Scott B. Crown, Scott P. Lyons

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 422 - 437.e8

Published: Feb. 1, 2024

Language: Английский

Citations

11
Dietary fasting and time-restricted eating in Huntington’s disease: therapeutic potential and underlying mechanisms DOI Creative Commons
Russell G. Wells, Lee E. Neilson, Andrew W. McHill

et al.

Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)

Published: April 2, 2024

Abstract Huntington's disease (HD) is a devastating neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) protein, resulting from CAG repeat expansion in gene HTT . HD characterized variety debilitating symptoms including involuntary movements, cognitive impairment, and psychiatric disturbances. Despite considerable efforts, effective disease-modifying treatments for remain elusive, necessitating exploration novel therapeutic approaches, lifestyle modifications that could delay symptom onset progression. Recent studies suggest time-restricted eating (TRE), form intermittent fasting involving daily caloric intake within limited time window, may hold promise treatment diseases, HD. TRE has been shown to improve mitochondrial function, upregulate autophagy, reduce oxidative stress, regulate sleep–wake cycle, enhance function. In this review, we explore potential role HD, focusing on its underlying physiological mechanisms. We discuss how might clearance mHTT, recover striatal brain-derived neurotrophic factor levels, function stress-response pathways, synchronize circadian rhythm activity. Understanding these mechanisms critical development targeted interventions mitigate pathology patient outcomes. While benefits animal models are encouraging, future comprehensive clinical trials will be necessary evaluate safety, feasibility, efficacy persons with

Language: Английский

Citations

11
Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential DOI Creative Commons

Alexander Fuerlinger,

Alina Stockner, Simon Sedej

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 18, 2025

Language: Английский

Citations

2