Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 2, 2025
Background
The
systemic
immunity-inflammation
index(SII)
is
a
new
indicator
of
composite
inflammatory
response.
Inflammatory
response
an
important
pathological
process
in
stroke.
Therefore,
this
study
sought
to
investigate
the
association
between
SII
and
Methods
We
collected
data
on
participants
with
stroke
from
2015–2020
cycle
National
Health
Nutrition
Examination
Survey
(NHANES)
for
cross-sectional
investigation.
Multivariate
linear
regression
models
were
used
test
Fitted
smoothing
curves
threshold
effect
analysis
applied
describe
nonlinear
relationship.
Results
A
total
13,287
included
our
study,
including
611
(4.598%)
In
multivariate
analysis,
we
found
significant
positive
stroke,
odds
ratio
(OR)
[95%
CI]
associating
prevalence
was
[1.02
(1.01,
1.04)]
(P
<
0.01).
subgroup
interaction
experiments,
that
relationship
not
significantly
correlated
among
different
population
settings
such
as
age,
gender,
race,
education
level,
smoking
status,
high
blood
pressure,
diabetes
coronary
heart
disease
trend
>
0.05).
Moreover,
inflection
point
740
(1,000
cells
/µl)
by
using
two-segment
model.
Conclusions
This
implies
increased
levels
are
linked
To
confirm
findings,
more
large-scale
prospective
investigations
needed.
Journal of Inflammation Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 1623 - 1638
Published: Feb. 1, 2025
Objective:
Hypertension
development
and
progression
are
largely
influenced
by
inflammation,
which
plays
a
critical
role
activating
the
immune
system
causing
damage
to
vascular
endothelium.
Metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)
is
also
associated
with
chronic
low-grade
drives
via
metabolic
imbalances
adipose
tissue
dysfunction.
This
study
investigates
relationship
between
inflammatory
indices
MAFLD
in
hypertensive
patients
assesses
predictive
accuracy
of
these
for
MAFLD.
Methods:
We
performed
cross-sectional
analysis
involving
34,303
from
Chinese
hospital-based
registry.
The
diagnosis
was
established
using
dysfunction
criteria
alongside
evidence
hepatic
steatosis
confirmed
through
imaging.
Complete
blood
counts
were
used
calculate
indices,
including
monocyte-to-lymphocyte
ratio
(MLR),
neutrophil-to-lymphocyte
(NLR),
platelet-to-lymphocyte
(PLR),
systemic
response
index
(SIRI),
immune-inflammation
(SII),
aggregate
inflammation
(AISI).
To
assess
MAFLD,
multivariable
logistic
regression
adjustments
potential
confounders.
diagnostic
performance
analyzed
receiver
operating
characteristic
(ROC)
curves
area
under
curve
(AUC)
calculations.
Results:
Patients
exhibited
significantly
elevated
levels
all
compared
those
without.
After
adjustment,
each
standard
deviation
increase
AISI,
SIRI,
SII
74%,
62%,
58%
increased
odds
respectively.
AUC
AISI
0.659,
indicating
moderate
accuracy.
AUCs
SIRI
0.626
0.619,
respectively,
while
NLR,
PLR,
MLR
had
lower
0.593,
0.558,
0.589,
Conclusion:
In
patients,
especially
show
strong
association
their
utility
risk
stratification
within
clinical
settings.
Further
research
needed
evaluate
effectiveness
markers
management
Keywords:
metabolic-dysfunction-associated
disease,
hypertension,
Frontiers in Neurology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 15, 2024
Background
Less
research
has
linked
the
Systemic
Immune
Inflammatory
Index
(SII)
with
post-stroke
depression
(PSD).
This
study
aims
to
look
at
any
potential
connections
between
SII
and
PSD.
Methods
The
National
Health
Nutrition
Examination
Survey
(NHANES),
conducted
in
a
population
that
embodied
complete
stroke
data
from
2005
2020,
was
used
perform
current
cross-sectional
survey.
A
fitted
smoothed
curve
depict
nonlinear
link
PSD,
multiple
linear
regression
analysis
demonstrated
positive
correlation
Results
Multiple
showed
PSD
were
markedly
related
[1.11(1.05,
1.17)].
Interaction
tests
association
not
statistically
different
strata,
age,
sex,
BMI,
income
poverty
ratio,
education
level,
smoking
status,
diabetes
mellitus,
coronary
heart
disease,
failure
did
have
significant
effect
on
this
(
p
>
0.05
for
interaction).
In
addition,
found
using
two-stage
model.
Conclusion
results
of
our
support
existence
levels
Further
prospective
trials
are
required
comprehend
SII,
which
is
thoroughly.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 18, 2024
The
exposure
of
Ethylene
oxide
(EO)
is
linked
to
systemic
inflammatory
response
and
various
cardiovascular
risk
factors.
Hemoglobin's
binding
ethylene
(HbEO)
was
used
measure
serum
EO
level.
This
research
aims
explore
the
association
between
metabolic
syndrome
(MetS)
HbEO,
HbEO
components
syndrome.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: June 5, 2024
There
is
limited
research
on
the
relationship
between
Systemic
Oxidative
Stress
(SOS)
status
and
inflammatory
indices.
Adding
onto
existing
literature,
this
study
aimed
to
examine
association
dietary
Balance
Score
(OBS)
lifestyle
OBS
(which
make
up
overall
OBS),
Cardiovascular
Disease
(CVD)
prevalence
at
different
Immune
Inflammation
Index
(SII)
Inflammatory
Response
(SIRI)
levels.
This
involved
9,451
subjects
selected
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2007-2018.
The
comprised
20
factors.
Statistical
methods
included
Weighted
Linear
Regression
Analysis
(WLRA),
Logistic
(LRA),
Sensitivity
(SA),
Restricted
Cubic
Spline
(RCS)
analysis.
multivariate
WLRA
revealed
that
was
significantly
negatively
correlated
with
both
SII
(β
=
-5.36,
p
<
0.001)
SIRI
-0.013,
In
SA,
removing
any
single
component
had
no
significant
effect
results
of
SIRI.
Further
subgroup
analyses
more
impactful
in
lowering
women
than
men.
Additionally,
low-age
group
high-age
group.
Moreover,
RCS
analysis
confirmed
linear
relationship.
Compared
OBS,
exerted
a
Coronary
Artery
(CAD)
(OR:
0.794,
0.002),
hypertension
0.738,
0.001),
Congestive
Heart
Failure
(CHF)
0.736,
0.005),
Myocardial
Infarction
(MI)
0.785,
stroke
0.807,
0.029)
prevalence.
Furthermore,
exhibited
interaction
CHF
(P
for
0.001).
On
other
hand,
MI
0.05).
including
were
associated
Higher
reduced
risks
CAD,
hypertension,
CHF,
MI,
stroke.
BMC Public Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Aug. 26, 2024
Given
the
global
shifts
in
environmental
conditions
and
dietary
habits,
understanding
potential
impact
of
factors
body
mass
index
(BMI)
on
respiratory
diseases,
including
asthma,
is
paramount.
Investigating
these
relationships
can
contribute
to
formulation
more
effective
prevention
strategies.
The
Planetary
Health
Diet
Index
(PHDI),
a
scoring
system
that
balances
human
health
with
sustainability,
underscores
importance
increasing
consumption
plant-based
foods
while
reducing
intake
red
meat,
sugar,
highly
processed
foods.
objective
this
study
was
assess
association
between
PHDI
prevalence
asthma
mediation
effect
BMI
US
general
population.
This
utilized
data
from
32,388
participants
National
Nutrition
Examination
Survey
(NHANES)
spanning
2005
2018.
Multivariate
logistic
regression
weighted
quantile
sum
(WQS)
regressions
were
employed
investigate
PHDI,
individual
nutrients,
asthma.
Restricted
cubic
spline
(RCS)
analysis
explored
linear
or
non-linear
relationship
Interaction
analyses
conducted
subgroups
validate
findings.
Mediation
performed
examine
There
significant
negative
After
adjusting
for
covariates,
every
10-point
increase
there
4%
decrease
(P
=
0.025).
Moreover,
as
increased,
trend
towards
lower
<
0.05).
WQS
showed
consistent
associations
(OR
0.93,
95%CI:
0.88,
0.98),
Fiber,
Vitamin
C,
Protein
factors.
dose-response
curve
indicated
higher
associated
prevalence.
Additionally,
significantly
positively
0.001),
decreases
increases
(β
-0.64,
P
0.001).
indicates
mediates
proportion
33.85%
results
show
strong
correlation
In
addition,
mediated
relationship.
Frontiers in Public Health,
Journal Year:
2024,
Volume and Issue:
12
Published: July 31, 2024
Objective
This
study
aimed
to
evaluate
the
association
between
six
complete
blood
count
(CBC)-derived
inflammatory
markers
[neutrophil-to-lymphocyte
ratio
(NLR),
monocyte-to-lymphocyte
(MLR),
platelet-to-lymphocyte
(PLR),
systemic
immune-inflammatory
index
(SII),
response
(SIRI),
and
pan-immune
inflammation
value
(PIV)]
risk
of
frailty
mortality.
Methods
Data
were
obtained
from
National
Health
Nutrition
Examination
Survey
(NHANES)
1999–2018.
Mortality
was
identified
using
Death
Index
until
December
31,
2019.
Multiple
logistic
regression
analysis
conducted
CBC-derived
frailty.
The
Cox
model
assessed
mortality
in
frail
populations.
Restricted
cubic
spline
(RCS)
used
visualize
with
risk.
predictive
for
further
a
random
survival
forest
(RSF)
approach.
Results
analyzed
data
total
16,705
middle-aged
older
participants.
Among
them,
6,503
participants
frail,
rate
41.47%.
showed
that
NLR,
MLR,
PLR,
SII,
SIRI,
PIV
positively
associated
revealed
highest
quartile
had
significantly
increased
death
compared
those
lowest
quartile:
NLR
(HR
=
1.73,
95%
CI:1.54,
1.94),
MLR
1.71,
CI:1.51,
1.93),
PLR
1.28,
95%CI:
1.15,
1.43),
SII
1.50,
95%CI:1.34,
1.68),
SIRI
1.88,
CI
95%:1.67,
2.12),
1.55,
95%CI:1.38,
1.73).
Random
analyses
demonstrated
adult
Conclusion
results
suggest
are
higher
as
well
middle
old-aged
population
United
States.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 10, 2024
Background
Inflammation
has
been
reported
to
be
related
anemia.
As
a
novel
inflammatory
marker,
Systemic
immune-inflammation
index
(SII)
not
studied
with
Anemia.
The
aim
of
this
study
was
investigate
the
possible
relationship
between
SII
and
Methods
This
retrospective
cross-sectional
survey
conducted
using
data
from
2005–2018
National
Health
Nutrition
Examination
Survey
(NHANES)
population.
In
total,
19851
American
adults
aged
≥18
years
were
included.
calculated
as
platelet
count×neutrophil
count/lymphocyte
count.
Anemia
defined
hemoglobin
(Hgb)
levels
<
13
g/dL
in
males
12
females.
Logistic
regression
analyses,
subgroup
analyses
sensitivity
performed
Results
Our
included
total
patients,
which
1501
(7.6%)
had
After
adjusting
for
all
covariates,
multivariate
logistic
analysis
showed
that
higher
(In-transform)
level
associated
increased
likelihood
anemia
(OR=1.51,
95%
CI:
1.36–1.68,
P<0.001).
association
exhibited
nonlinear
manner.
positive
correlation
severity
Subgroup
there
no
significant
dependence
on
age,
family
income,
body
mass
index,
hypertension,
kidney
disease
cancer
except
gender
association.
Furthermore,
confirmed
robustness
our
results.
Conclusion
demonstrated
positively
especially
among
female
participants.
And
Further
large-scale
prospective
studies
are
still
needed
analyze
role
Frontiers in Neurology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 31, 2025
Background
Many
inflammatory
markers
like
systemic
immune-inflammatory
index
(SII),
neutrophil-lymphocyte
ratio
(NLR),
and
platelet-lymphocyte
(PLR)
are
associated
with
stroke.
However,
studies
on
the
relationship
between
stroke
response
(SIRI)
scarce.
This
study
was
aimed
at
evaluating
potential
association
of
SIRI
Methods
Our
cross-sectional
included
adults
sufficient
data
from
2005-2018
National
Health
Nutrition
Examination
Survey
(NHANES).
We
used
multivariable
logistic
regression,
interaction
tests,
smoothed
curve
fitting,
subgroup
analysis
for
assessing
independent
Results
Of
36,176
participants
in
this
study,
1,414
(3.9%)
had
experienced
a
In
fully
adjusted
model,
displayed
significant
positive
correlation
(odds
[OR]
=
1.09,
95%
confidence
interval
[CI]
1.04–1.15,
p
0.0006).
Meanwhile,
odds
increased
by
39%
4th
quartile,
relative
to
1st
quartile
(OR
1.39,
CI
1.17–1.65,
0.0002).
Additional
tests
revealed
that
age,
sex,
race,
education,
marriage,
BMI
(body
mass
index),
smoking,
diabetes
mellitus,
hypertension,
coronary
heart
disease
(CHD)
were
not
positively
correlated
(
>0.05).
Moreover,
we
also
found
nonlinear
stroke,
an
inflection
point
2.17.
Conclusion
results
indicate
is
significantly
related
stroke;
however,
its
role
needs
be
further
confirmed
large-scale
prospective
studies.
