Correlation between weight-adjusted waist index and coronary heart disease: NHANES 1999–2020

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 10, 2025

The weight adjusted waist index (WWI) represents a novel indicator for assessing central obesity. objective of this study is to investigate the association between WWI and coronary heart disease (CHD). data 44,528 participants in total were gathered from NHANES database 1999 2020. calculated as circumference (WC, cm) divided by square root body (kg), CHD was determined based on participants' self-reports. examined using multiple logistic regression analysis, restrictive cubic spline (RCS), receiver operating characteristic (ROC) curve, mediation subgroup interaction analyses. This cross-sectional investigation. A included [50.23% male; mean 10.89 (0.01) cm/√kg]. multivariate analysis revealed that three models, one-standard-deviation increment associated with an increased probability occurrence 2.39 (2.22,2.57),1.47 (1.32,1.65), 1.15 (1.00,1.32) times, respectively. Additionally, RCS indicated linear relationship CHD. ROC results showed discriminatory power superior mass (BMI) WC. Glycated hemoglobin (HbA1c) partially mediated Subgroup analyses confirmed age, systolic blood pressure, diabetes status had significant impact (P <0.05). level has been demonstrated be risk Specifically, increases, becomes higher. On basis, it hypothesized may potentially serve independent factor CAD, thereby highlighting substantial value identification management

Language: Английский

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Association of Neutrophil-Percentage-To-Albumin Ratio(NPAR) with depression symptoms in U.S. adults: a NHANES study from 2011 to 2018

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 28, 2024

Inflammation is crucial in the development of depression. This study aims to examine potential association between Neutrophil-Percentage-to-Albumin Ratio(NPAR) and depression symptoms. adopted a cross-sectional design, involving patients with symptoms those without comprehensive NPAR data originated from National Health Nutrition Examination Survey(NHANES) spanning 2011 2018. The research utilized weighted multivariate logistic regression models linear investigate relationship levels its severity scores. characterization nonlinear relationships was accomplished by employing fitted smoothing curves. Furthermore, subgroup analyses interaction assessments were conducted offer additional insights. involved total 10,829 participants, prevalence among them found be 15.08%. multiple analysis revealed statistically significant positive continuum symptoms[OR:1.03, 95% CI: (1.00, 1.05)], as well scores[β: 0.08, (0.04,0.11)]. Stratifying into quartiles, we that higher associated increased odds analysis, there no differences or scores within populations diabetes cardiovascular diseases. Additionally, use two-stage model uncovered non-linear Our indicates To corroborate our findings, larger prospective studies are warranted elucidate associations greater detail.

Language: Английский

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Associations between sugar-sweetened beverage consumption, weight-adjusted-waist index, with psychological symptoms: a cross-sectional survey of adolescents in mainland China

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 28, 2025

The prevalence of psychological symptoms (emotional problems, behavioral social adjustment difficulties) in adolescents continues to increase and has become a major concern various countries. However, few studies have been conducted on the association between sugar-sweetened beverage (SSB) consumption, weight-adjusted waist index (WWI), adolescents. present study provides reference for prevention intervention Chinese A multistage stratified whole cluster random sampling method was used assess symptoms, SSB weight, circumference, demographic information 44,675 aged 12-17 years mainland China 2023. associations WWI, among were analyzed using logistic regression model analysis ordered with generalized linear model. 20.9%, boys (21.4%) having higher than girls (20.5%), difference statistically significant (χ 2 value 5.687, P < 0.05). proportion consumption >4 times/week 14.5%, WWI 9.36 ± 1.13. Ordered showed that, <1 quartile Q1 as group, Q4 had highest risk developing (OR=2.01, 95% CI:1.76-2.30) (P <0.001). same trend observed (OR=1.67, CI: 1.39-2.00) (OR=2.68, 2.17-3.31) adolescent is high associated WWI. Effectively reducing plays positive role symptoms.

Language: Английский

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Associations of weight-adjusted-waist index and systemic immune-inflammatory index with sKlotho: evidence from the NHANES 2007-2016

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 1, 2025

Background Klotho is an anti-aging protein, and obesity inflammation have been identified as having a relationship with Klotho. This study investigated the correlation between weight-adjusted-waist index(WWI), systemic index(SII) soluble (sKlotho) explored potential mediating role of SII. Methods The association WWI, SII, sKlotho was using weighted multivariate linear regression, subgroup analysis, smoothed curve fitting in this cross-sectional study, which based on NHANES data. Bootstrap method used to test for mediation effects. Covariate selection validated variance inflation factor (VIF). Results involved total 9,506 participants. results showed that WWI (β=-0.03; 95%CI:-0.04,-0.01; p &lt;0.0001) associated SII (β=-0.00, 95%CI:-0.00,-0.00: &lt;0.001) Ln-sKlotho.There negative both sKlotho. Subgroup analysis gender, age, education, marital status, family income, HEI, PA, hypertension, diabetes, CKD, alcohol use, smoking, did not affect (FDR-corrected &gt;0.1). played significant effect sKlotho, 6.78% Conclusion There may be important mediator Reducing inflammatory conditions obese populations increase levels, turn delay organismal aging middle-aged elderly people.

Language: Английский

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The mediating roles of obesity indicators and serum albumin in the association of DEET exposure with depression and sleep disorders in adults: evidence from NHANES 2007-2016

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 6, 2025

Language: Английский

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Investigating the shared genetic architecture between obesity and depression: a large-scale genomewide cross-trait analysis

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Introduction Increasing evidence suggests that individuals with obesity are at a higher risk of developing depression, and conversely, depression can contribute to the onset obesity, creating detrimental cycle. This study aims investigate potential shared biological pathways between by examining genetic correlations, identifying common polymorphisms, conducting cross-trait analyses. Methods We assessed correlation using linkage disequilibrium score regression high-density lipoprotein levels. combined two different sources data METAL employed bidirectional Mendelian randomization determine causal relationship depression. Additionally, we conducted multivariate trait analysis MTAG method improve statistical robustness identify novel associations. Furthermore, performed thorough investigation independent loci GCTA-COJO, PLACO, MAGMA, POPS, SMR, integrating QTL information methods further genes proteins. Results Our revealed correlations positive relationships highlighting SNP (rs10789340). identified RPL31P12, NEGR1, DCC as for Using BLISS method, SCG3 FLRT2 drug targets. Limitation Most our from Europe, which may limit generalization findings other ethnic populations. Conclusion demonstrates SNPs, genes, proteins, These deeper understanding their pathogenesis identification therapeutic

Language: Английский

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Sex-specific association of weight-adjusted waist index with mortality in stroke survivors: a national longitudinal cohort study

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 35(2), P. 103743 - 103743

Published: Sept. 19, 2024

Language: Английский

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Weight-Adjusted Waist Index (WWI)—A Promising Anthropometric Indicator of Depressive Symptoms in Hospitalized Older Patients

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 68 - 68

Published: Dec. 28, 2024

Objectives: The aim of this study was to evaluate which anthropometric index, either body mass index (BMI) or weight-adjusted waist (WWI), is more accurately associated with the prevalence most common chronic diseases and components geriatric assessment in hospitalized older adults. Methods: included a total 2945 adults (median age 82 years). associations between presence Comprehensive Geriatric Assessment (CGA) results were compared WWI BMI values. Results: significantly higher both sex groups suffering from hypertension, diabetes, osteoarthritis, depression. In women, parameter increased among individuals previous myocardial infarction, who presented heart failure symptoms had kidney disease diagnosed, whereas men, those pulmonary osteoporosis, related many CGA parameters oftentimes where proved fail. There positive correlation depressive assessed depression scale (GDS) but no significant BMI. multiple logistic regression models, stronger predictor as circumference waist-to-height ratio. Conclusions: an association diagnosis well according GDS adults, women men. such Both high values seem identify patients cardiometabolic hypertension diabetes. According study, seems be promising indicator risk and, similarly BMI, useful for

Language: Английский

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