Disturbance of the Circadian System in Shift Work and Its Health Impact

Journal of Biological Rhythms, Journal Year: 2021, Volume and Issue: 37(1), P. 3 - 28

Published: Dec. 30, 2021

The various non-standard schedules required of shift workers force abrupt changes in the timing sleep and light-dark exposure. These result disturbances endogenous circadian system its misalignment with environment. Simulated night-shift experiments field-based studies both indicate that is resistant to adaptation from a day- night-oriented schedule, as determined by lack substantial phase shifts over multiple days centrally controlled rhythms, such those melatonin cortisol. There evidence disruption caused work results not only between external cycle, but also state internal desynchronization levels system. This case rhythms central pacemaker clock genes expression tissues peripheral blood mononuclear cells, hair follicle oral mucosa cells. disruptive effects atypical extend beyond profile canonical affects other transcripts human genome. In general, after several living at night, most rhythmic genome remain adjusted day-oriented dampened group amplitudes. contrast transcripts, metabolomics revealed metabolites hours when working nights, thus leading their Altogether, these sleep-wake emphasize all-encompassing impact work, can contribute increased risk medical conditions. Here, we review latest scientific regarding on system, alertness shift-working populations, discuss potential clinical impacts.

Language: Английский

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Circadian autophagy drives iTRF-mediated longevity

Nature, Journal Year: 2021, Volume and Issue: 598(7880), P. 353 - 358

Published: Sept. 29, 2021

Language: Английский

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Timing Matters: The Interplay between Early Mealtime, Circadian Rhythms, Gene Expression, Circadian Hormones, and Metabolism—A Narrative Review

Clocks & Sleep, Journal Year: 2023, Volume and Issue: 5(3), P. 507 - 535

Published: Sept. 6, 2023

Achieving synchronization between the central and peripheral body clocks is essential for ensuring optimal metabolic function. Meal timing an emerging field of research that investigates influence eating patterns on our circadian rhythm, metabolism, overall health. This narrative review examines relationship meal timing, clock genes, hormones, It analyzes existing literature experimental data to explore connection mealtime, rhythms, processes. The available evidence highlights importance aligning mealtime with body’s natural rhythms promote health prevent disorders. Specifically, studies show consuming meals later in day associated elevated prevalence disorders, while early time-restricted eating, such as having breakfast earlier dinner, improves levels glucose blood substrate oxidation. Circadian including cortisol melatonin, interact mealtimes play vital roles regulating Cortisol, aligned dawn diurnal mammals, activates energy reserves, stimulates appetite, influences gene expression, synchronizes clocks. Consuming during periods melatonin levels, specifically night, has been correlated potential implications tolerance. Understanding mechanisms synchronization, genetics, interactions chronotype, sleep duration, hormonal changes, provides valuable insights optimizing dietary strategies timing. knowledge contributes improved well-being by rhythm.

Language: Английский

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Meal timing and its role in obesity and associated diseases

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: March 22, 2024

Meal timing emerges as a crucial factor influencing metabolic health that can be explained by the tight interaction between endogenous circadian clock and homeostasis. Mistimed food intake, such delayed or nighttime consumption, leads to desynchronization of internal is associated with an increased risk for obesity disturbances type 2 diabetes cardiovascular diseases. Conversely, meal aligned cellular rhythms optimize performance tissues organs. In this review, we provide overview effects discuss underlying mechanisms. Additionally, explore factors timing, including determinants chronotype genetics, well external influences like social factors, cultural aspects, work schedules. This review could contribute defining meal-timing-based recommendations public initiatives developing guidelines effective lifestyle modifications targeting prevention treatment Furthermore, it sheds light on must considered in design future intervention trials.

Language: Английский

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Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 529 - 529

Published: Jan. 31, 2025

Fasting-feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal underscores importance maintaining alignment order to avoid creating metabolic environment conducive carcinogenesis following molecular systemic disruption performance immune function. chronicity such condition may support initiation progression cancer through variety mechanisms, including increased oxidative stress, suppression, activation proliferative signaling pathways. This review aims summarize current evidence from human studies provide an overview potential mechanisms underscoring role chrononutrition (including time-restricted eating) on risk. Current shows that morning chronotype, suggesting physiological rhythms eating timing, associated with lower risk cancer. Also, early prolonged nighttime fasting were also suggests chronotype influences cell cycle regulation, modulation pathways inflammation, gut microbiota fluctuations. In conclusion, although there are no clear guidelines this matter, emerging supports hypothesis time-related (i.e., time/calorie-restricted feeding intermittent/periodic fasting) could potentially lead reduced

Language: Английский

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Circadian rhythmicity of body temperature and metabolism

Temperature, Journal Year: 2020, Volume and Issue: 7(4), P. 321 - 362

Published: March 16, 2020

This article reviews the literature on circadian rhythms of body temperature and whole-organism metabolism. The two are first described separately, each description preceded by a review research methods. Both generated endogenously but can be affected exogenous factors. relationship between is discussed next. In endothermic animals, modulation metabolic activity affect temperature, rhythm not mere side effect thermogenesis associated with general activity. system modulates heat production to generate rhythm, which challenges homeothermy does abolish it. Individual cells do regulate their own metabolism at cellular level also discussed. Metabolism both an output input clock, meaning that rhythmicity intertwined in cell.

Language: Английский

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Nuts and bolts of the salt-inducible kinases (SIKs)

Biochemical Journal, Journal Year: 2021, Volume and Issue: 478(7), P. 1377 - 1397

Published: April 16, 2021

The salt-inducible kinases, SIK1, SIK2 and SIK3, most closely resemble the AMP-activated protein kinase (AMPK) other AMPK-related like these family members they require phosphorylation by LKB1 to be catalytically active. However, unlike kinases are phosphorylated cyclic AMP-dependent (PKA), which promotes their binding 14-3-3 proteins inactivation. well-established substrates of SIKs CREB-regulated transcriptional co-activators (CRTCs), Class 2a histone deacetylases (HDAC4/5/7/9). Phosphorylation translocation CRTCs HDACs cytoplasm 14-3-3s, preventing them from regulating nuclear partners, transcription factors CREB MEF2. This process is reversed PKA-dependent inactivation leading dephosphorylation re-entry into nucleus. Through reversible regulation others that have not yet been identified, regulate many physiological processes ranging innate immunity, circadian rhythms bone formation, skin pigmentation metabolism. review summarises current knowledge evidence underpinning findings, discusses therapeutic potential SIK inhibitors for treatment disease.

Language: Английский

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Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks

Genes & Development, Journal Year: 2021, Volume and Issue: 35(5-6), P. 329 - 334

Published: Feb. 18, 2021

It has been assumed that the suprachiasmatic nucleus (SCN) synchronizes peripheral circadian oscillators. However, this never convincingly shown, since biochemical time series experiments are not feasible in behaviorally arrhythmic animals. By using long-term bioluminescence recording freely moving mice, we show SCN is indeed required for maintaining synchrony between organs. Surprisingly, however, oscillations persist livers of mice devoid an or oscillators cells other than hepatocytes. Hence, similar to neurons, hepatocytes can maintain phase coherence absence Zeitgeber signals produced by organs environmental cycles.

Language: Английский

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Differential Effects of Constant Light and Dim Light at Night on the Circadian Control of Metabolism and Behavior

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(15), P. 5478 - 5478

Published: July 31, 2020

The disruption of circadian rhythms by environmental conditions can induce alterations in body homeostasis, from behavior to metabolism. light:dark cycle is the most reliable agent, which entrains rhythms, although its credibility has decreased because extensive use artificial light at night. Light pollution compromise performance and health, but underlying mechanisms are not fully understood. present review assesses consequences induced constant (LL) comparison with dim night (dLAN) on control metabolism rodents, since such an approach identify key chronodisruption. Data suggest that effects LL more pronounced compared dLAN directly related level duration exposure. Dim LAN reduces nocturnal melatonin levels, similarly LL, corticosterone behavioral traits uniform improved quantification disrupted needed. Metabolism under strong lead various pathologies. Moreover, only output, some metabolites peripheral signal molecules feedback clockwork either stabilize or amplify desynchronization.

Language: Английский

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The phosphorylation switch that regulates ticking of the circadian clock

Molecular Cell, Journal Year: 2021, Volume and Issue: 81(6), P. 1133 - 1146

Published: Feb. 5, 2021

Language: Английский

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