Decrease in Sperm Parameters in the 21st Century: Obesity, Lifestyle, or Environmental Factors? An Updated Narrative Review

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 198 - 198

Published: Feb. 11, 2024

Semen quality represents a compelling factor for fertility, and delineating the normal values has proven difficult. In last four decades, several authors have reported noticeable decline in sperm parameters. Also, studies investigating ‘time to pregnancy’ shown that fecundity begins be reduced when numbers decrease below 30 million, even though according 6th edition of WHO manual, value is currently 16 million/mL or 39 million per ejaculate. There exists sufficient data suggest counts over time, clear reason this adverse trend not well established, but some associations been hypothesised, such as maternal smoking during pregnancy. Additional potential factors yet fully illustrated involve poor diet, increased obesity, exposure environmental toxins. Moreover, change conditions more common endocrine-disrupting chemicals (EDCs), pesticides herbicides, bisphenol A, phthalates, polychlorinated biphenyls, heavy metals, starting from prenatal life continuing into adulthood, may exhibit probable features explaining reduction Therefore, main goal narrative review furnish an overview possible effects EDCs on testicular function spermatogenesis and, also, summarise evidence regarding examine its consequences.

Language: Английский

---

Optimum Doses and Forms of Selenium Maintaining Reproductive Health via Regulating Homeostasis of Gut Microbiota and Testicular Redox, Inflammation, Cell Proliferation, and Apoptosis in Roosters

Journal of Nutrition, Journal Year: 2023, Volume and Issue: 154(2), P. 369 - 380

Published: Dec. 19, 2023

Language: Английский

---

Redox Homeostasis and Nrf2-Regulated Mechanisms Are Relevant to Male Infertility

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 193 - 193

Published: Feb. 3, 2024

Infertility represents a significant global health challenge, affecting more than 12% of couples worldwide, and most cases infertility are caused by male factors. Several pathological pathways implicated in infertility. The main mechanisms involved driven the loss reduction–oxidation (redox) homeostasis resulting oxidative damage as well chronic inflammatory process. Increased or severe stress leads to sperm plasma membrane DNA damage, dysregulated RNA processing, telomere destruction. signaling these molecular events also regulated Nuclear factor-E2-related factor 2 (Nrf2). causes infertility, role Keap1-Nrf2 antioxidant pathway reviewed. This review highlights regulatory Nrf2 balance between oxidants antioxidants relevant fertility. is regulation spermatogenesis quality. Establishing link fertility provides basis for modulation processes, reactive oxygen species generation, network, including Nrf2-regulated response, improve reproductive outcomes.

Language: Английский

---

Advancements in Genetic Biomarkers and Exogenous Antioxidant Supplementation for Safeguarding Mammalian Cells against Heat-Induced Oxidative Stress and Apoptosis

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 258 - 258

Published: Feb. 20, 2024

Heat stress represents a pervasive global concern with far-reaching implications for the reproductive efficiency of both animal and human populations. An extensive body published research on heat effects utilizes controlled experimental environments to expose cells tissues its disruptive influence physiological aspects phenotypic traits, encompassing parameters such as sperm quality, motility, viability, overall competence. Beyond these immediate effects, has been linked embryo losses, compromised oocyte development, even infertility across diverse species. One primary mechanisms underlying adverse outcomes is elevation reactive oxygen species (ROS) levels precipitating oxidative apoptosis within mammalian cells. Oxidative are recognized pivotal biological factors through which exerts impact male female In concerted effort mitigate detrimental consequences stress, supplementation antioxidants, in natural synthetic forms, explored potential intervention strategy. Furthermore, possess inherent self-protective that come into play during episodes aiding their survival. This comprehensive review delves multifaceted traits elucidates intricate molecular underpinning cells, compromise normal function. Additionally, we provide succinct overview antioxidant interventions highlight genetic biomarkers capabilities, collectively offering promising avenues ameliorating negative by restraining stress.

Language: Английский

---

The association between consumption of ultra-processed foods and sperm quality parameters: a cross-sectional study

BMC Research Notes, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 1, 2025

While recent studies suggest a correlation between unhealthy dietary patterns, oxidative stress, inflammation, and male infertility, the potential association ultra-processed foods (UPFs) infertility remains underexplored. Therefore, aim of present study was to investigate UPF intake by evaluating sperm quality parameters. The participants (n = 260) current cross-sectional were recruited from an center in Isfahan Province, Iran. Four semen parameters—such as total motility, concentration, volume, normal morphology—were evaluated. Also, participants' food assessed using validated 168-item frequency questionnaire. Moreover, NOVA system employed calculate index. UPFs parameters analyzed logistic regression. In crude model, no significant associations observed second last tertiles with abnormalities morphology (p > 0.05 for all). However, after adjusting age, marriage duration, body mass index, physical activity, depression, anxiety, energy intake, cigarette history, mineral vitamin supplements, significantly higher identified tertile concentration (odds ratio (OR) 3.962, 95% confidence interval (CI): 1.345–11.670, p 0.013). conclusion, although analysis did not find consumption impaired motility morphology, it revealed trends linking lower concentration. If future confirm these results, they could aid designing interventional preventive programs aimed at addressing men reproductive age field public health.

Language: Английский

---

Polygonatum sibiricum polysaccharide attenuates cyclophosphamide-induced testicular damages and sperm defects in male mice via Nrf2 mediating antioxidant protective mechanisms

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141968 - 141968

Published: March 1, 2025

Language: Английский

---

Captivating Colors, Crucial Roles: Astaxanthin’s Antioxidant Impact on Fish Oxidative Stress and Reproductive Performance

Animals, Journal Year: 2023, Volume and Issue: 13(21), P. 3357 - 3357

Published: Oct. 29, 2023

Fish, constantly exposed to environmental stressors due their aquatic habitat and high metabolic rates, are susceptible oxidative stress. This review examines the interplay between stress fish reproduction, emphasizing potent antioxidant properties of astaxanthin. Our primary objective is highlight astaxanthin's role in mitigating during critical reproductive stages, leading improved gamete quality, ovary development, hormone levels. We also explore its practical applications aquaculture, including enhanced pigmentation overall health. conducted a comprehensive literature review, analyzing studies on impact reproduction. Astaxanthin, carotenoid pigment, effectively combats reactive oxygen species, inhibiting lipid peroxidation maintaining membrane integrity. It significantly enhances success improves health aquaculture settings. reveals multifaceted benefits offering economic advantages aquaculture. Future research should delve into species-specific responses, optimal dosages, long-term effects astaxanthin supplementation inform sustainable strategies.

Language: Английский

---

Human Papillomavirus and Male Infertility: What Do We Know?

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17562 - 17562

Published: Dec. 16, 2023

In recent years, increasing attention has been paid to understanding the causes of infertility, which is being recognized as a growing health problem affecting large numbers couples worldwide. Male infertility contributing factor in approximately 30-40% cases, and one its etiological sexually transmitted infections (STIs). Among pathogens, human papillomavirus (HPV) can contribute various ways failure spontaneous assisted reproduction, acting different phases conception, especially early ones. particular, HPV infection affect sperm DNA integrity, motility, count, viability, morphology induce production anti-sperm antibodies (ASAs). this narrative review, we aimed provide an overview existing research on potential adverse effects male reproductive health. Furthermore, analyzed how limiting spread infection, particularly with gender-neutral vaccination, could be possible therapeutic tool counteract female fertility problems.

Language: Английский

---

Protective Role of Melatonin Against Abamectin-Induced Biochemical, Immunohistochemical, and Ultrastructural Alterations in the Testicular Tissues of Rats

Microscopy and Microanalysis, Journal Year: 2024, Volume and Issue: 30(5), P. 962 - 977

Published: Aug. 27, 2024

Abamectin is one of the most widely used pesticides due to its strong insecticidal and anthelmintic activities. Melatonin a neurohormone with potent antioxidant, anti-apoptotic, anti-inflammatory effects. This study aimed investigate potential ameliorative effects melatonin against abamectin-induced testicular toxicity in rats. Twenty-four rats were divided into four groups: control group (1 mL/kg/day corn oil), melatonin-treated (10 mg/kg/day), abamectin-treated (0.5 plus group. Test substances administered via oral gavage once daily for 28 days. While MDA 8-OHdG levels increased tissue treated abamectin, SOD, CAT, GPx, GST enzyme activities decreased significantly. interleukin-17 levels, TNF-α, caspase3 expression tissue, acetylcholinesterase activity decreased. At same time, serum gonadotropins (luteinizing follicle-stimulating hormones) testosterone Light microscope examinations tissues revealed severe histopathological changes, such as atrophic hyalinized seminiferous tubules, basement membrane irregularity, degeneration, spermatogenic cell loss, necrosis. Electron microscopy large vacuoles Sertoli cells, swelling vacuolization mitochondria, lysosomal structures, pyknotic nuclei. In contrast, supplementation significantly ameliorated through antiapoptotic, mechanisms.

Language: Английский

---

The Role of Selected Elements in Oxidative Stress Protection: Key to Healthy Fertility and Reproduction

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9409 - 9409

Published: Aug. 29, 2024

Oxidative stress and its relationship to fertility reproduction is a topic of interest in medicine, especially the context effects trace elements micronutrients. occurs when there an excess free radicals body, which can lead cell tissue damage. Free are reactive oxygen species (ROS) that be formed as result normal metabolic processes, well under influence external factors such environmental pollution, UV radiation, diet. has significant impact on fertility. In men, it DNA damage sperm, reduced semen quality, sperm motility increased numbers defective radical membranes causing reduction number available sperm. women, oxidative affect quality female reproductive cells, problems with their maturation embryo implantation uterus also ovarian function disrupt hormonal regulation menstrual cycle. A proper balance micronutrients key protecting against maintaining health. Supplementation appropriate zinc, selenium, copper, manganese, chromium, iron help reduce improve This work discusses selected parameters specifically terms reproduction.

Language: Английский

---