Functional Amino Acids in Growth, Reproduction, and Health

Advances in Nutrition, Journal Year: 2010, Volume and Issue: 1(1), P. 31 - 37

Published: Nov. 1, 2010

Language: Английский

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Physiological and molecular determinants of embryo implantation

Molecular Aspects of Medicine, Journal Year: 2013, Volume and Issue: 34(5), P. 939 - 980

Published: Jan. 2, 2013

Language: Английский

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Novel pathways for implantation and establishment and maintenance of pregnancy in mammals

Molecular Human Reproduction, Journal Year: 2009, Volume and Issue: 16(3), P. 135 - 152

Published: Oct. 30, 2009

Uterine receptivity to implantation varies among species, and involves changes in expression of genes that are coordinate with attachment trophectoderm uterine lumenal superficial glandular epithelia, modification phenotype stromal cells, silencing receptors for progesterone estrogen, suppression immune recognition, alterations membrane permeability enhance conceptus-maternal exchange factors, angiogenesis vasculogenesis, increased vascularity the endometrium, activation transport nutrients into lumen, enhanced signaling pregnancy recognition.Differential by epithelial cells response progesterone, glucocorticoids, prostaglandins interferons may influence mammals.Uterine is progesterone-dependent; however, preceded loss (PGR) so most likely acts via PGR-positive throughout pregnancy.Endogenous retroviruses expressed uterus and/or blastocyst also affect placentation various species.Understanding roles variety hormones, growth factors endogenous retroviral proteins essential enhancing reproductive health fertility humans domestic animals.

Language: Английский

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Conceptus-Induced Changes in the Endometrial Transcriptome: How Soon Does the Cow Know She Is Pregnant?1

Biology of Reproduction, Journal Year: 2011, Volume and Issue: 85(1), P. 144 - 156

Published: Feb. 24, 2011

This study sought to determine the earliest response of bovine uterine endometrium presence conceptus at key developmental stages early pregnancy. There were no detectable differences in gene expression endometria from pregnant and cyclic heifers on Days 5, 7, 13 postestrus, but 764 genes was altered due maternal recognition pregnancy (Day 16). Of these 514 genes, MX2, BST2, RSAD2, ISG15, OAS1, USP18, IFI44, ISG20, SAMD9, EIF4E, IFIT2 increased greatest extent (>8-fold log2 fold change increase). The OXTR, Bt.643 (unofficial symbol), KCNMA1 reduced most, short-term treatment with recombinant ovine interferon tau (IFNT) vitro or vivo did not alter their expression. In intrauterine infusion IFNT induced IFIT2, USP18. These results revealed for first time that changes occur endometrial transcriptome are independent a until recognition. differentially expressed (including SAMD, EIF4E) consequence production by conceptus. identified represent known novel markers development and/or return cyclicity may be useful identify stage which is detectable.

Language: Английский

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Impacts of arginine nutrition on embryonic and fetal development in mammals

Amino Acids, Journal Year: 2013, Volume and Issue: 45(2), P. 241 - 256

Published: June 3, 2013

Language: Английский

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The Unexplained Female Predominance of Systemic Lupus Erythematosus: Clues from Genetic and Cytokine Studies

Clinical Reviews in Allergy & Immunology, Journal Year: 2010, Volume and Issue: 40(1), P. 42 - 49

Published: Jan. 9, 2010

Language: Английский

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The role of mesenchymal–epithelial transition in endometrial function

Human Reproduction Update, Journal Year: 2018, Volume and Issue: 25(1), P. 114 - 133

Published: Oct. 13, 2018

The human uterine endometrium undergoes significant remodeling and regeneration on a rapid repeated basis, after parturition, menstruation, in some cases, injury. ability of the adult to undergo cyclic differentiation/decidualization is essential for successful reproduction. Multiple key physiologic functions require cells this tissue transition between mesenchymal epithelial phenotypes, processes known as mesenchymal-epithelial (MET) epithelial-mesenchymal (EMT). Although MET/EMT have been widely characterized embryonic development context malignancy, mounting evidence demonstrates importance allowing phenotypic functional flexibility necessary decidualization, regeneration/re-epithelialization embryo implantation.The objective review provide comprehensive summary observations concerning MET EMT their regulation functions, specifically endometrial regeneration, decidualization implantation.Using variations search terms 'mesenchymal-epithelial transition', transformation', 'epithelial-mesenchymal 'uterus', 'endometrial regeneration', decidualization', 'embryo implantation', published literature 1970 2018 was conducted using PubMed database. In addition, we searched reference lists all publications included additional relevant original studies.Multiple studies demonstrate that stromal contribute both cell compartments uterus, implicating role mechanisms responsible re-epithelialization. During morphologic changes consistent with order accommodate implantation. Under influence estradiol, progesterone multiple other factors, fibroblasts acquire epithelioid characteristics, such expanded cytoplasm rough endoplasmic reticulum required greater secretory capacity, rounded nuclei, increased expression junctional proteins which allow cell-cell communication, reorganized actin cytoskeleton. implantation, response maternal embryonic-derived signals, luminal epithelium well decidualized characteristics migration/motility, thus undergoing invading trophoblast.Overall, findings support important roles may be considered unique wound healing model, given its repeatedly repair without scarring or loss function. Future elucidate how scar-free will considerable potential advance tissues.

Language: Английский

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Pig blastocyst–uterine interactions

Differentiation, Journal Year: 2014, Volume and Issue: 87(1-2), P. 52 - 65

Published: Jan. 1, 2014

Language: Английский

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Influence of progesterone on oocyte quality and embryo development in cows

Theriogenology, Journal Year: 2011, Volume and Issue: 76(9), P. 1594 - 1601

Published: Aug. 18, 2011

Language: Английский

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Embryo–epithelium interactions during implantation at a glance

Journal of Cell Science, Journal Year: 2017, Volume and Issue: 130(1), P. 15 - 22

Published: Jan. 1, 2017

ABSTRACT At implantation, with the acquisition of a receptive phenotype in uterine epithelium, an initial tenuous attachment embryonic trophectoderm initiates reorganisation epithelial polarity to enable stable embryo and differentiation invasive trophoblasts. In this Cell Science at Glance article, we describe cellular molecular events during phase implantation rodent, drawing on morphological studies both vivo vitro, genetic models. Evidence is emerging for repertoire transcription factors downstream master steroidal regulators estrogen progesterone that coordinate alterations polarity, delivery signals stroma cell death or displacement. We discuss what known interactions occur before considering specific adhesion molecules. compare rodent data our much more limited knowledge human system, where direct mechanistic evidence hard obtain. accompanying poster, represent embryo–epithelium humans laboratory rodents, highlighting similarities differences, as well depict some key biological interstitial occur.

Language: Английский

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