Cyclic Decidualization of the Human Endometrium in Reproductive Health and Failure

Endocrine Reviews, Journal Year: 2014, Volume and Issue: 35(6), P. 851 - 905

Published: Aug. 20, 2014

Decidualization denotes the transformation of endometrial stromal fibroblasts into specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix essential for embryo implantation placental development. In contrast to most mammals, decidualization human endometrium does not require implantation. Instead, this process is driven by postovulatory rise in progesterone levels increasing local cAMP production. response falling levels, spontaneous causes menstrual shedding cyclic regeneration endometrium. A growing body evidence indicates shift from embryonic maternal control represents pivotal evolutionary adaptation challenge posed invasive chromosomally diverse embryos. This concept predicated on ability decidualizing respond individual embryos manner either promotes further development or facilitates early rejection. Furthermore, menstruation involves stem cell recruitment renders intrinsically capable adapting its maximize reproductive success. Here we review endocrine, paracrine, autocrine cues tightly govern differentiation process. activation various signaling pathways genome-wide chromatin remodeling, evolutionarily conserved transcriptional factors gain access decidua-specific regulatory circuitry. Once initiated, poised transit through distinct phenotypic phases underpin receptivity, selection, and, ultimately, resolution pregnancy. We discuss how disorders subvert programming, initiation, progression compromise health predispose pregnancy failure.

Language: Английский

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Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

Nature Cell Biology, Journal Year: 2017, Volume and Issue: 19(5), P. 568 - 577

Published: April 10, 2017

Language: Английский

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Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium

eLife, Journal Year: 2017, Volume and Issue: 6

Published: Dec. 11, 2017

In cycling human endometrium, menstruation is followed by rapid estrogen-dependent growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the transcription factor Forkhead box O1 (FOXO1) in endometrial stromal cells (EnSCs), leading to cell cycle exit differentiation into decidual that control embryo implantation. Here we show FOXO1 also causes acute senescence of a subpopulation decidualizing EnSCs an IL-8 dependent manner. Selective depletion or enrichment this revealed drives transient inflammatory response associated with receptivity. Further, senescent prevent mesenchymal stem cultures. As progresses, IL-15 activated uterine natural killer (uNK) selectively target clear through granule exocytosis. Our findings reveal governs rejuvenation remodeling at implantation, suggest critical role for uNK maintaining homeostasis endometrium.

Language: Английский

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Embryo–epithelium interactions during implantation at a glance

Journal of Cell Science, Journal Year: 2017, Volume and Issue: 130(1), P. 15 - 22

Published: Jan. 1, 2017

ABSTRACT At implantation, with the acquisition of a receptive phenotype in uterine epithelium, an initial tenuous attachment embryonic trophectoderm initiates reorganisation epithelial polarity to enable stable embryo and differentiation invasive trophoblasts. In this Cell Science at Glance article, we describe cellular molecular events during phase implantation rodent, drawing on morphological studies both vivo vitro, genetic models. Evidence is emerging for repertoire transcription factors downstream master steroidal regulators estrogen progesterone that coordinate alterations polarity, delivery signals stroma cell death or displacement. We discuss what known interactions occur before considering specific adhesion molecules. compare rodent data our much more limited knowledge human system, where direct mechanistic evidence hard obtain. accompanying poster, represent embryo–epithelium humans laboratory rodents, highlighting similarities differences, as well depict some key biological interstitial occur.

Language: Английский

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Physiologic Events of Embryo Implantation and Decidualization in Human and Non-Human Primates

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(6), P. 1973 - 1973

Published: March 13, 2020

Reproduction is a fundamental process for the preservation of human species. This requires sequence orchestrated events that are necessary successful pregnancy. Two most critical steps in establishment pregnancy implantation and decidualization, which required maternal interactions with developing embryo. review primarily highlights physiological aspects these two adverse outcomes from defective decidualization. The focus this to provide general concept mechanisms involved during window implantation, description components possible pathologies could disrupt embryo decidualization specifically as it applies women non-human primates.

Language: Английский

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What is the contribution of embryo-endometrial asynchrony to implantation failure?

Journal of Assisted Reproduction and Genetics, Journal Year: 2016, Volume and Issue: 33(11), P. 1419 - 1430

Published: Aug. 1, 2016

Language: Английский

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Physical and neurobehavioral determinants of reproductive onset and success

Nature Genetics, Journal Year: 2016, Volume and Issue: 48(6), P. 617 - 623

Published: April 18, 2016

Language: Английский

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Role of microRNAs in embryo implantation

Reproductive Biology and Endocrinology, Journal Year: 2017, Volume and Issue: 15(1)

Published: Nov. 21, 2017

Failure of embryo implantation is a major limiting factor in early pregnancy and assisted reproduction. Determinants include the viability, endometrial receptivity, embryo-maternal interactions. Multiple molecules are involved regulation implantation, but their specific regulatory mechanisms remain unclear. MicroRNA (miRNA), functioning as transcriptional regulator gene expression, has been widely reported to be implantation. Recent studies reveal that miRNAs not only act inside cells, also can released by cells into extracellular environment through multiple packaging forms, facilitating intercellular communication providing indicative information associated with physiological pathological conditions. The discovery shed new light on studies. MiRNAs provide for communication. Moreover, they may serve non-invasive biomarkers selection assessment receptivity reproduction, which improves accuracy evaluation while reducing mechanical damage tissue. In this review, we discuss involvement from several aspects, focusing role potential applications reproductive technologies (ART) promote fertility efficiency.

Language: Английский

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Molecular basis of thyrotropin and thyroid hormone action during implantation and early development

Human Reproduction Update, Journal Year: 2014, Volume and Issue: 20(6), P. 884 - 904

Published: June 18, 2014

Implantation and early embryo development are finely regulated processes in which several molecules involved. Evidence that thyroid hormones (TH: T4 T3) might be part of this machinery is emerging. An increased demand for TH occurs during gestation, any alteration maternal physiology has significant implications both fetal health. Not only overt but also subclinical hypothyroidism associated with infertility as well obstetric complications, including disruptions disorders pregnancy, labor, delivery, troubles neonatal life. We searched the PubMed Google Scholar databases articles related to action on ovary, endometrium, trophoblast maturation implantation. In addition, regulation activity at cellular level have been reviewed. The findings hereby summarized critically discussed. shown influence endometrial, ovarian placental physiology. receptors (TR) thyrotropin (thyroid-stimulating hormone: TSH) (TSHR) widely expressed feto-maternal unit implantation, endometrium influenced by either directly or through effects synthesis implantation-mediating molecules. Interestingly, due multiplicity mechanisms involved (e.g. differential expression TR isoforms, heterodimeric receptor partners, interacting proteins, regulating enzymes), concentration blood not always predictive their availability genomic nongenomic level. addition known role hormonal milieu follicle cycle, essential a woman's fertility, evidence emerging importance signaling implantation pregnancy. Based recent observations, local female reproductive organs appears crucial successful Furthermore, an imbalance spatio-temporal factors induce arrest pregnancy women considered euthyroid, based concentration. conclusion, alterations highly may play crucial, previously underestimated, loss. Further studies elucidating topic should encouraged.

Language: Английский

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Uterine glands coordinate on-time embryo implantation and impact endometrial decidualization for pregnancy success

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: June 18, 2018

Abstract Uterine glands are essential for pregnancy establishment. By employing forkhead box A2 (FOXA2)-deficient mouse models coupled with leukemia inhibitory factor (LIF) repletion, we reveal definitive roles of uterine in embryo implantation and stromal cell decidualization. Here report that LIF from the initiates embryo-uterine communication, leading to attachment Detailed histological molecular analyses discovered crypt formation does not involve glands, but removal luminal epithelium is delayed subsequent decidualization fails LIF-replaced glandless gland-containing FOXA2-deficient mice. Adverse ripple effects those dysregulated events uterus result resorption failure. These studies provide evidence synchronize embryo-endometrial interactions, coordinate on-time implantation, impact decidualization, thereby ensuring viability, placental growth, success.

Language: Английский

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