Molecular Mechanisms of Neuroprotection after the Intermittent Exposures of Hypercapnic Hypoxia

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3665 - 3665

Published: March 25, 2024

The review introduces the stages of formation and experimental confirmation hypothesis regarding mutual potentiation neuroprotective effects hypoxia hypercapnia during their combined influence (hypercapnic hypoxia). main focus is on mechanisms signaling pathways involved in ischemic tolerance brain intermittent hypercapnic hypoxia. Importantly, effect exerts a more pronounced compared to separate application. Some systems are associated with predominance hypoxic stimulus (HIF-1α, A1 receptors), while others (NF-κB, antioxidant activity, inhibition apoptosis, maintenance selective blood-brain barrier permeability) mainly modulated by hypercapnia. Most molecular cellular ischemia due contribution both excess carbon dioxide oxygen deficiency (ATP-dependent potassium channels, chaperones, endoplasmic reticulum stress, mitochondrial metabolism reprogramming). Overall, studies indicate dominance its action Recent clinical have demonstrated effectiveness hypercapnic-hypoxic training treatment childhood cerebral palsy diabetic polyneuropathy children. Combining pharmacological modulators neuro/cardio/cytoprotection likely be promising for translating research into medicine.

Language: Английский

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Cerebral Palsy: A Current Perspective

NeoReviews, Journal Year: 2024, Volume and Issue: 25(6), P. e350 - e360

Published: June 1, 2024

Cerebral palsy (CP) is the most common cause of motor disability in children. Insults to brain at different times lead diverse injuries. As a result, CP an extremely heterogeneous clinical diagnosis, presenting differently each individual and various ages. With improving survival rates preterm newborns, increasing active resuscitation widespread availability extensive genetic testing soon after birth, it imperative focus on earlier diagnosis long-term outcomes CP. primarily classified into 4 categories based type impairment, functional ability, distribution, etiology. understanding has evolved significantly last 2 decades, methods early detection have consequently advanced. Appropriate essential for proper education counseling affected families, introduction therapeutic interventions as possible. In this review, we development provide overview etiology, classification, options, prognosis

Language: Английский

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Longitudinal Hammersmith Infant Neurological Examination (HINE) Trajectories in Children with Cerebral Palsy Identified in High-Risk Follow-Up

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1572 - 1572

Published: Feb. 26, 2025

Background/Objectives: The Hammersmith Infant Neurological Examination (HINE) is a standardized neurologic exam for infants between 2 and 24 months. Scores can be compared to optimality cutoffs as one component support an early diagnosis of cerebral palsy (CP). Some prognosis also possible diagnosed with CP. We aimed understand the longitudinal trajectories HINE scores in who were ultimately Methods: Clinical records reviewed children CP two high-risk infant follow-up clinics from at least visits corrected ages 3 months years. Trajectories calculated individually by group four categories—term neonatal hypoxic ischemic encephalopathy (HIE), term perinatal arterial stroke (PAIS), premature brain injury, “Other” (term congenital malformations and/or hydrocephalus). changes clinic using linear mixed-effect models random intercept, pulling data diagnostic across accounting within-child correlations over time. Results: sixty (twenty-five prematurity, eighteen HIE, seven PAIS, ten other category) assessed. indicated that PAIS had estimated 10.8-point increase total after 9 age earlier assessments (95% CI [2.5, 19.2]. There was no statistically significant improvement among injury groups. 2.9-point asymmetry prior [0.7, 5.1]). None categories increases Conclusions: resultant hemiplegia showed increasing throughout first years life. In contrast, remained stable those prematurity-associated hydrocephalus Tracking individual (or stability) aid diagnosis, inform prognosis, guide design clinical trials targeting injury.

Language: Английский

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Perinatal and postnatal markers of cerebral palsy

CHILD`S HEALTH, Journal Year: 2025, Volume and Issue: 20(2), P. 122 - 127

Published: April 22, 2025

Background. The aim of this study is to identify adverse factors the perinatal and postnatal periods that provoke onset cerebral palsy. Materials methods. experimental used theoretical methods aimed at analysing results scientific research drawing conclusions. Empirical included analysis, comparison, data processing, interviews, a questionnaire for parents children with latter questions covered (information about parents, pregnancy), intrapartum (features course childbirth) (assessment child’s general neuromotor function) development. Indicators first manifestations neurological symptoms concomitant disorders were studied. Results. materials give clear idea period development an important stage foetal functioning. Identification pathological allows preventing negative consequences in advance. studied palsy high risk Their mothers experienced severe toxicosis/gestosis during pregnancy hospital. health condition deteriorated due chronic, infectious, viral diseases, swelling extremities affected period, including labour, which often required medical or mechanical stimulation. Hypoxia, asphyxia ischaemia detected newborns. They found be underweight, short, need artificial feeding, prolonged painful condition. Children developed differently most them had delayed (holding head, sitting, standing, walking) compared normal peers. During examinations, diagnosed spastic diplegia, left-sided hyperkinesis, tetraparesis, hemiparesis. also disorders, namely: speech hearing, vision (strabismus), mental retardation. Conclusions. A comprehensive perinatal, extremely important. Early diagnosis will allow building ways perspective rehabilitation, outline conditions physical, emotional, cognitive social child palsy, improve quality life integration into society.

Language: Английский

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Global State of the Art and Science of Childhood Dysphagia: Similarities and Disparities in Burden

Dysphagia, Journal Year: 2024, Volume and Issue: 39(6), P. 989 - 1000

Published: March 19, 2024

Language: Английский

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Implementation of remote general movement assessment using the in-motion instructions in a high-risk norwegian cohort

BMC Pediatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 10, 2024

Abstract Background General Movement Assessment (GMA) is recommended for early detection of risk cerebral palsy but requires trained clinical experts. We aimed to implement home- and hospital-based filming remote GMA in a Norwegian high-risk infant cohort, as well evaluating parents’ experiences their at home. Methods This knowledge translational study used prospective cohort design including participants referred neurodevelopmental follow-up across three sites the Central Norway Regional Health Authority. Two home films fidgety type general movements were collected between 12 +1 –14 +6 15 –17 weeks after term by parents. An additional film was hospital 17 term. The instructional guide all In-Motion App standards. Videos transferred team classified either “GMA scorable” or not based on Prechtl’s Parents responded an online survey using 5-point Likert scale collect information about perspectives, experiences, possible worries Results One-hundred-and-two infants from 95 families participated. Ninety-two (96.8%) 177 home-based videos. Eighty-four (92%) these had videos taken local hospital. All home-videos (3,1%) out scorable”. Eight did respond two receive due technical error. Seventy-eight (91.7%) respondents agreed strongly that it easy perform five (5.9%) they more worried child`s development Almost 80% video can be instead Conclusions strengthens implementation parents CP programs. has potential facilitate intervention improve function children with line international recommendations. Trial registration ClinicalTrials.gov ID: NCT04287166 Date registration: 27/02/2020.

Language: Английский

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Remote General Movement Assessment for early detection of Cerebral Palsy in high-risk infants: A Knowledge Translational Study implementing home filming in a Norwegian cohort.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Background General Movement Assessment (GMA) is recommended for early detection of risk cerebral palsy but requires trained clinical experts. We aimed to implement home- and hospital-based filming remote GMA in a Norwegian high-risk infant cohort, as well evaluating parents’ experiences their at home. Methods This knowledge translational study used prospective cohort design including participants referred neurodevelopmental follow-up across three sites the Central Norway Regional Health Authority. Two home films fidgety type general movements were collected between 12^{+ 1}-14^{+ 6} 15^{+ 1}-17^{+ weeks after term by parents. An additional film was hospital 1} 17^{+ term. The instructional guide all In-Motion App standards. Videos transferred team classified either “GMA scorable” or not based on Prechtl’s Parents responded an online survey using 5-point Likert scale collect information about perspectives, experiences, possible worries Results One-hundred-and-two infants from 95 families participated. Ninety-two (96.8%) 177 home-based videos. Eighty-four (92%) these had videos taken local hospital. All home-videos (3,1%) out scorable”. Eight did respond two receive due technical error. Seventy-eight (91.7%) respondents agreed strongly that it easy perform five (5.9%) they more worried child`s development Almost 80% video can be instead Conclusion strengthens implementation parents CP programs. has potential facilitate intervention improve function children with line international recommendations. Trial registration: ClinicalTrials.gov ID: NCT04287166 Date 27/02/2020}

Language: Английский

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Grand Rounds: How Do We Detect Cerebral Palsy Earlier in Neonates ?

The Journal of Pediatrics, Journal Year: 2024, Volume and Issue: unknown, P. 114299 - 114299

Published: Sept. 1, 2024

Language: Английский

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