Sleep Medicine Clinics, Journal Year: 2024, Volume and Issue: 20(1), P. 93 - 102
Published: Nov. 16, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 24, 2025
Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.
Language: Английский
Citations
3
Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2025, Volume and Issue: 61(1), P. 145 - 152
Published: Jan. 1, 2025
Language: Английский
Citations
0
Brain Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 100219 - 100219
Published: April 1, 2025
Language: Английский
Citations
0
Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 1358 - 1365
Published: Jan. 1, 2025
Language: Английский
Citations
0
BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)
Published: June 22, 2024
Parkinson's disease (PD) is a neurodegenerative for which no disease-modifying therapies exist. Preclinical and clinical evidence suggest that repeated exposure to intermittent hypoxia might have short- long-term benefits in PD. In previous exploratory phase I trial, we demonstrated in-clinic safe feasible with short-term symptomatic effects on PD symptoms. The current study aims explore the safety, tolerability, feasibility, net of four-week protocol, administered at home, individuals
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6512 - 6512
Published: June 13, 2024
The review discusses the potential relationship between hypoxia resistance and longevity, influence of carbon dioxide on mechanisms aging mammalian organism, intermittent hypercapnic-hypoxic effects signaling pathways mechanisms. In article, we focused gero-protective efficacy when combined with hypoxia. summarizes possible hypercapnia processes in nervous system. We considered perspective variants application influences for achieving active longevity prospects possibilities developing training methods.
Language: Английский
Citations
1
Sleep Medicine Clinics, Journal Year: 2024, Volume and Issue: 20(1), P. 93 - 102
Published: Nov. 16, 2024
Language: Английский
Citations
0