How Much Does SARS-CoV-2 Infection during Pregnancy Affect the Neonatal Brain, Heart, and Kidney? A Parallel between COVID-19, Vaccination, and Normal Pregnancy

Life, Journal Year: 2024, Volume and Issue: 14(2), P. 224 - 224

Published: Feb. 5, 2024

During the last decades, a growing number of studies have shown that infections during pregnancy an important impact on both pregnant women and their fetuses. Our goal was to include newborns from pregnancies with SARS-CoV-2 infection investigate extension neonatal complications using cardiac, abdominal, cerebral ultrasonography; hearing testing; indirect ophthalmoscopy. Likewise, neonates whose mothers were vaccinated against COVID-19 those pathology-free examined. A total 458 mother–newborn dyads included over period 10 months divided into three groups: group, vaccine control group. Although six cardiac malformations found in no correlation made compared group (p = 0.07). Grade 1 intraventricular hemorrhage hypoxic ischemic encephalopathy most prevalent among 0.002 p < 0.001, respectively). The kidney anomaly be frequent this grade unilateral hydronephrosis 0.001). disease gestational had effect auditory or visual function. findings highlight importance implementing proper practices for future mothers, by continuing topic, we can gather valuable insights will improve health context.

Language: Английский

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Perinatal arterial ischemic stroke: how informative is the placenta?

Virchows Archiv, Journal Year: 2024, Volume and Issue: 484(5), P. 815 - 825

Published: March 19, 2024

Abstract Neuroplacentology is an expanding field of interest that addresses the placental influence on fetal and neonatal brain lesions further neurodevelopment. The objective this study was to clarify link between pathology perinatal arterial ischemic stroke (PAIS). Prior publications have reported different types with diverse methodologies precluding firm conclusions. We report here histological findings in a series 16 neonates radiologically confirmed PAIS. Findings were grouped into 3 categories lesions: (1) inflammation, (2) hypoxic lesions, (3) placentas high birthweight/placenta weight ratio. Matched control compared pathological when feasible. eight term singleton 20 from highly controlled amniotic membrane donation program; three twin pregnancies, portions affected unaffected co-twin compared. Slightly more than half (9/16, 56%) had histopathological features belonging one category, feature shared by (13/20, 65%). More severe extensive however observed placentas. One case occurring context SARS-CoV-2 placentitis expands spectrum COVID-related disease. Our supports assumption PAIS can result various combinations interplay maternal factors confirms value placenta examination. Yet, must be interpreted caution given their prevalence well-designed controls.

Language: Английский

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Implications of COVID-19 Pandemic on Pregnancy: Current Status and Controversies

COVID, Journal Year: 2023, Volume and Issue: 3(6), P. 859 - 873

Published: May 26, 2023

The COVID-19 pandemic unnerved the global population in 2019 and has continued to evolve ever since. Throughout this time, investigations concerning health of groups most susceptible virus, including elderly, those with compromised immunity or chronic diseases, pregnant women, have taken place. Numerous articles been formulated on effects infection maternal, fetal, neonatal health, but there are many controversies that still exist within current literature. Even three years later, it is not fully understood how a maternal vaccination can impact pregnancy fetus, these topics require further investigation conclusive results. aim article explain risks for mother neonate, during after pregnancy, emergence pandemic. Additionally, report presents state literature whether more beneficial harmful. Finally, review examines studies regarding exacerbation pregnancies various organ systems, particularly cardiovascular system, relevance pre-existing emerging conditions ethnicity mother.

Language: Английский

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Case report: Post-COVID new-onset neurocognitive decline with bilateral mesial-temporal hypometabolism in two previously healthy sisters

Frontiers in Pediatrics, Journal Year: 2023, Volume and Issue: 11

Published: May 26, 2023

Long coronavirus disease (COVID) is increasingly recognized in adults and children; however, it still poorly characterized from a clinical diagnostic perspective, particularly the younger populations.

Language: Английский

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Effects of SARS-CoV-2 gestational exposure and risk factors on neurodevelopment until 12 months: A prospective cohort study in Brazil

Early Human Development, Journal Year: 2023, Volume and Issue: 188, P. 105918 - 105918

Published: Dec. 13, 2023

Language: Английский

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Acute and Long COVID Intestinal Changes in an Experimental Model of Coronavirus in Mice

Viruses, Journal Year: 2024, Volume and Issue: 16(6), P. 832 - 832

Published: May 24, 2024

The COVID-19 pandemic, which emerged in early 2020, has had a profound and lasting impact on global health, resulting over 7.0 million deaths persistent challenges. In addition to acute concerns, there is growing attention being given the long COVID health consequences for survivors of with documented cases cardiovascular abnormalities, liver disturbances, lung complications, kidney issues, noticeable cognitive deficits. Recent studies have investigated physiological changes various organs following prolonged exposure murine hepatitis virus-1 (MHV-1), coronavirus, mouse models. One significant finding relates effects gastrointestinal tract, an area previously understudied regarding long-lasting COVID-19. This research sheds light important observations intestines during both phases MHV-1 infection, parallel specific seen humans after SARS-CoV-2. Our study investigates histopathological alterations small intestine infection models, revealing reminiscent inflammatory bowel disease (IBD), celiac disease. Notable findings include mucosal inflammation, lymphoid hyperplasia, goblet cell immune infiltration, mirroring pathological features observed IBD. Additionally, induces villous atrophy, altered epithelial integrity, responses akin SPIKENET (SPK) treatment effectively mitigates intestinal damage caused by restoring tissue architecture ameliorating responses. Furthermore, investigation into reveals intricate profiles, highlighting potential SPK modulate restore homeostasis. Understanding these provides valuable insights pathogenesis COVID-induced complications informs development targeted therapeutic strategies.

Language: Английский

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COVID-19 and Its Potential Impact on Children Born to Mothers Infected During Pregnancy: A Comprehensive Review

Diagnostics, Journal Year: 2024, Volume and Issue: 14(21), P. 2443 - 2443

Published: Oct. 31, 2024

Pregnancy is a vulnerable period of time during which pregnant people are prone to infections like COVID-19, can increase risks for both the mother and fetus. These may lead complications such as preterm birth, developmental delays, congenital abnormalities. While COVID-19 poses additional placental dysfunction neonatal infections, studies on long-term effects remain limited. Ongoing research monitoring essential understand mitigate potential cognitive challenges in children born mothers infected with COVID-19. This review aims guide clinicians managing these throughout childhood. Maternal infection pregnancy have significant implications fetal development, even if newborn not at birth. The release inflammatory cytokines cross barrier, potentially disrupting brain development increasing risk behavioral issues, ADHD or autism. Placental dysfunction, caused by inflammation thrombosis, intrauterine growth restriction (IUGR), hypoxia, affecting neurological respiratory health newborns. Furthermore, compromised immune system susceptibility autoimmune conditions infections. early diagnosis management crucial mitigating Swift intervention prevent birth challenges, ensuring better outcomes child. Long-term necessary full extent virus's impact. evaluates systemic maternal fetuses, newborns, children, focusing beyond vertical transmission. It highlights broader impacts offering insights help manage issues that arise later life.

Language: Английский

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COVID -19: On the threshold of the fifth year. The situation in Spain

Revista Española de Quimioterapia, Journal Year: 2023, Volume and Issue: 37(1), P. 17 - 28

Published: Nov. 27, 2023

Despite having emerged from pandemic status, the incidence of COVID-19 episodes has recently increased in Spain, including pediatric cases and admissions to Intensive Care Units. Several recombinant variants are circulating among us, particularly XBB arising two Omicron BA.2 sublineages with mutations genes encoding spicule proteins that could increase binding ACE2 receptor be more prone immune escape. Faced these, 3 pharmaceutical companies have developed vaccines adapted XBB.1.5 sublineage already available for administration our setting risks should not different those previous mRNA clearly favorable benefit/risk ratios. They applied patients potential poor evolution collectives a particular relationship proximity them. Their application understood only perspective individual convenience but also collective responsibility. The most convenient seems simultaneous immunization influenza environment. In therapeutic aspect, there is little expect right now antisera, known antiviral drugs still indicated, although their efficacy will reevaluated due impact on populations mostly immunized better prognosis than past. opinion, it necessary continue make reasonable timely use masks other non-pharmacological means protection.

Language: Английский

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Acute and post-acute multidisciplinary outcomes of newborns born from mothers with SARS-CoV-2 infection during pregnancy or the perinatal period

Heliyon, Journal Year: 2023, Volume and Issue: 9(9), P. e19206 - e19206

Published: Aug. 19, 2023

Introduction.We performed a single-center, prospective, observational study of newborns born from mothers with microbiologically confirmed SARS-CoV-2 infection in pregnancy or at time delivery to evaluate acute and mid-term multidisciplinary outcomes.Methods.Infants were offered follow-up consisting nasopharyngeal Polymerase Chain Reaction test birth 48–72 h life, auxological ophthalmological assessments, serologic testing.Results.791 women their 791 children (52.3% males) included. Most placentas (94.9%) had abnormal inflammatory findings. 171 (27.3%) 36 (13.7%) respectively pathological TEOAEs least one ear bilaterally, while only four the 85 that underwent ABR findings (4.7%). 64 fluorescein angiography, which resulted 1 case (1.6%). Anti-SARS-CoV-2 IgGs found up 60% tested six months age. Our showed no association between maternal vaccination status presence symptoms during neonatal outcomes.Conclusions.Our shows large majority exposed utero first hours life have optimal outcomes. previous report ophthalmologic was not on larger cohort, further studies are needed better characterize audiological Further case-controlled still needed.

Language: Английский

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COVID-19-induced gastrointestinal autonomic dysfunction: A systematic review

World Journal of Clinical Cases, Journal Year: 2023, Volume and Issue: 11(22), P. 5246 - 5266

Published: Aug. 3, 2023

In recent years, because of the growing desire to improve noninvasiveness and safety tumor treatments, sonodynamic therapy has gradually become a popular research topic. However, due complexity therapeutic process, relevant mechanisms have not yet been fully elucidated. One widely accepted possibilities involves effect reactive oxygen species. this review, mechanism species production by (SDT) ways enhance are reviewed. Then, clinical application limitations SDT discussed. conclusion, current on should focus development sonosensitizers that efficiently produce active oxygen, exhibit biological safety, promote transformation therapy.

Language: Английский

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