Reactivation of cytomegalovirus, human herpes virus, and Epstein-Barr virus infections after hemapoietic stem cell transplantation in children
Journal Infectology,
Journal Year:
2024,
Volume and Issue:
15(4), P. 62 - 69
Published: Jan. 11, 2024
Study
objective:
to
evaluate
frequency
of
CMV,
HHV-6,
and
EBV
reactivation
in
children
within
60
days
after
HSCT.Materials
methods:
The
study
was
carried
out
Raisa
Gorbacheva
Memorial
Research
Institute
for
Pediatric
Oncology,
Hematology,
Transplantation
the
Pavlov
First
Saint
Petersburg
State
Medical
University
We
analyzed
95
medical
records
pediatric
patients
who
underwent
HSCT
2021.
Pretransplant
serostatus
EBV,
HHV-6
studied,
as
well
timing
virus
transplantation.
In
prospective
part,
35
aged
from
1
17
years
were
enrolled.
pretransplant
evaluation
included
detection
anti-CMV,
anti-HHV-6,
anti-EBV
IgM
IgG
by
ELISA,
blood
PCR
viremia.
DNA
herpes
viruses
identified
quantitative
on
day
HSCT,
then
10,
20,
30
HSCT.
number
viral
copies
calculated
per
105
cells.
Statistical
analysis
using
SPSS
Statistics
22
software
package.Results:
On
pre-transplant
evaluation,
47
tested
CMV
with
positive
result
36
children,
27
positive.
detected
3
25
patientsMostly,
occurred
early
period
up
days.
observed
average
25±4
transplantation,
significantly
earlier
than
EBV.In
a
study,
revealed
28
(80%)
maximum
20
HSCT.A
trend
toward
an
increase
concentration
10
load
minimal
replicative
activity.
Clinically
significant
manifestations
herpesvirus
infection
diagnosed
19
(54.3%)
patients.Conclusion:
High
seropositivity
before
Herpes
occurs
post-transplant
period,
20th
forms
mono-
mixed
predominates
increasing
load.
Language: Английский
A Single-Stage Population-Based Study of the Relationship between Cognitive and Somatic Health Parameters in Children of Secondary School Age
Annals of the Russian academy of medical sciences,
Journal Year:
2024,
Volume and Issue:
78(5), P. 408 - 430
Published: Jan. 22, 2024
Background.
One
of
the
four
important
components
formation
cognitive
functions
is
somatic
health.
But
to
date,
there
are
no
population
studies
that
consider
relationship
with
and
school
performance
a
large
range
factors,
which
allows
us
compare
strength
their
hypothetical
contribution
functioning
each
other.
This
study
second
part
population-based
study,
first
presented
in
previous
publication
"A
Single-Stage
Population-Based
Study
Prevalence
Mild
Cognitive
Impairment
Children
Secondary
School
Age".
Aims
—
determine
main
patterns
between
cognitive-academic
factors
cohort
Russian
children,
5th
grade
students
at
school.
Methods.
In
schoolchildren
grades
municipalities
representing
cities
all
federal
districts
Federation,
links
integrative
success,
number
subtests
performed
level
mild
impairment,
results
individual
subtests,
academic
leading
hand
factor
were
analyzed
following
factors:
presence
skin
pathology,
bronchial
asthma,
orthopedic,
ophthalmological
disorders,
visual
acuity,
body
mass
index,
parameters
function
external
respiration,
electrocardiography,
ultrasound
examination
thyroid
gland,
laboratory
blood
tests.
Results.
The
survey
1036
participants,
51%
them
girls,
admitted
analysis.
It
has
been
established
iron
content
directly
related
success
performance,
especially
strong
subgroups
above
below
26.4
mmol/l.
Clinical
levels
erythrocytes
more
strongly
associated
than
other
erythropenia
worse.
cysts
correlates
some
worst
activity.
High
index
low
hemoglobin
poorer
performance.
Conclusions.
for
time
on
showed
connection
activity
including
content,
requires
further
in-depth
study.
Language: Английский
A single-stage population-based study of the prevalence of mild cognitive impairment in children of secondary school age.
Annals of the Russian academy of medical sciences,
Journal Year:
2023,
Volume and Issue:
78(4), P. 329 - 347
Published: Nov. 1, 2023
Background:
Various
mild
cognitive
impairments
in
children
are
socially
significant
disorders
that
often
found
the
practice
of
pediatric
neurologists,
but
apparent
lack
epidemiological
data
does
not
allow
us
to
judge
scale
problem.
Aims:
The
aim
study
was
assess
prevalence
combined
a
large
cohort
Russian
children,
5th
grade
students
at
school.
Materials
and
methods:
results
examination
schoolchildren
municipalities
representing
cities
all
federal
districts
Federation
(RF)
analyzed.
Cognitive
functions
were
tested,
which
consisted
six
subtests.
According
testing,
using
method
assessing
population
studies,
frequency
assigning
participants
high-risk
group
impairment
probability
diagnosis
evaluated.
analysis
links
between
breadth
performed
level
impairment,
integrative
success,
individual
subtests
with
academic
performance
leading
hand
factor
carried
out.
.
Results:
1,067
school
included
study,
1,036
completed
it,
51%
them
girls.
Belonging
cluster
successes
representation
had
no
gender
differences,
for
visual-spatial
perception/memory
constructive
better
by
boys
(p
0.001
p
=
0.020),
girls,
as
rule,
verbal-logical
thinking
voluntary
activity.
attention
0.050
0.051).
high
risk
detected
30.2%
examined,
7.5%.
It
studied
factors,
obtained
moderate
effectiveness
subtest
more
related
performance.
At
same
time,
strength
these
ties
very
moderate.
image
way
associated
including
left-handedness
partially
literature.
Conclusions:
conducted
first
time
on
multi-regional
schoolchildren,
demonstrated
wide
potential
also
revealed
number
patterns
neurobiology
development.
Language: Английский
Aspects of cytomegalovirus reactivation in critically ill patients
Journal Infectology,
Journal Year:
2022,
Volume and Issue:
14(4), P. 61 - 68
Published: Oct. 18, 2022
Cytomegalovirus
plays
an
essential
role
in
human
pathology.
Primary
infection
usually
occurs
childhood
and
subsequently,
a
lifelong
latency
is
formed
which
the
virus
replicates
by
evading
immune
response.
In
recent
years,
more
researchers
have
concluded
that
cytomegalovirus
reactivation
may
occur
critically
ill
patients.
Despite
available
evidence,
data
on
this
group
of
patients
are
limited
relatively
small
sample
size,
variety
patient
groups
studied,
differences
study
methodology,
variability
reported
results,
excludes
possibility
summarizing
results.
This
aimed
to
determine
frequency
identify
its
main
clinical
features.
Materials
methods.
The
included
118
with
severe
bacterial
viral-bacterial
infections
accompanied
multiple
organ
dysfunction.
was
determined
detection
DNA
combination
presence
IgG.
Results.
Reactivation
detected
36.4%
cases.
Frequency
terms
blood
sputum
as
well
trends
viral
load
changes
dynamics
were
shown.
features
different
pathologies
(sepsis
etiology,
COVID-19,
non-septic
critical
patients)
noted.
HCMV
frequently
septic
(44.8%)
compared
COVID-19
(13.0%,
p<0.05)
(19.2%,
p<0.05).
characterized
not
only
lower
but
also
lowest
loads
(p<0.05).
comparably
sepsis
(38.1%)
(33.3%),
highest
characteristic
Language: Английский