From life history theory to clinical practice: potential markers of fast life strategy

CARDIOVASCULAR THERAPY AND PREVENTION, Journal Year: 2025, Volume and Issue: 23(12), P. 4198 - 4198

Published: Feb. 13, 2025

Currently, there is increasing evidence that early human development mediates the risk of cardiometabolic diseases and their factors in adulthood. This publication considers potential markers so-called fast life strategy — a cycle characterized by high disease risk, as well conditions leading to formation such strategy. In future, they may allow stratifying groups at premature death from cardiovascular metabolic routine clinical practice conducting prevention.

Language: Английский

---

Oscillatory wavelet-patterns in complex data: mutual estimation of frequencies and energy dynamics

The European Physical Journal Special Topics, Journal Year: 2022, Volume and Issue: 232(5), P. 595 - 603

Published: Dec. 9, 2022

Language: Английский

---

Obesity induced hypertension: The main pathophysiological mechanisms

Arterial’naya Gipertenziya (Arterial Hypertension), Journal Year: 2021, Volume and Issue: 27(3), P. 260 - 268

Published: Aug. 4, 2021

In most countries worldwide, hypertension (HTN) occupies a leading position in the structure of modifiable risk factors for cardiovascular diseases and their complications. One main reasons this trend is increasing prevalence obesity, which becoming an important factor high blood pressure (BP). The results numerous epidemiological studies showed association between obesity (assessed by body mass index (BMI)) BP levels, as well prognostic role BMI relation to development HTN. However, there currently no consensus on criterion that accurately predicts HTN associated Data from prospective observational greater value indirect direct indicators abdominal ectopic visceral adipose tissue.These facts stimulated research aimed at revealing pathophysiological mechanisms patients with overweight are reviewed article.

Language: Английский

---

Metabolic health of the population: a modern view of the problem and solutions

Russian Journal of Cardiology, Journal Year: 2024, Volume and Issue: 29(5), P. 5896 - 5896

Published: April 11, 2024

Studying the metabolic health of population around world is becoming a priority area modern medicine. This associated with an increase in prevalence overweight and obesity, which leads to significant related diseases, are actually complications primarily visceral. According 2019 data, obesity 5 million deaths 160 disability-adjusted life years, more than half due cardiovascular diseases. challenge requires development cardiometabolic medicine training new specialists.

Language: Английский

---

Clinical-molecular and nutritional-metabolic characteristics of vibration disease in combination with arterial hypertension

Russian Journal of Occupational Health and Industrial Ecology, Journal Year: 2024, Volume and Issue: 64(5), P. 280 - 292

Published: June 20, 2024

Introduction. Vibration disease (VD) in Russia consistently ranks second or third among all occupational pathology caused by physical factors of the production environment. The is characterized polysyndromicity with frequent development polymorbid conditions, including arterial hypertension (AH), a persistent course even after elimination causal factor, and disability. Therefore, clarifying nutritional-metabolic molecular-genetic mechanisms formation VD combination AH will optimize diagnosis evaluation effectiveness treatment, which promising for clinic medicine internal diseases. study aims to determine additional diagnostic markers comorbid variant vibration based on clinical functional, nutritional metabolic molecular genetic indicators. Materials methods. authors studied range clinical, anthropometric, laboratory, parameters 431 employees aviation plant: 104 patients stage I disease; 101 I–II; 107 I–II, not contact vibration; 119 people from same company, out vibration, without signs hypertension. Results. In group hypertension, we have found an increase frequency general specific complaints compared groups isolated Body mass index indicators correspond obesity 2 3 27.1%; 15.8%; whereas 1 prevail; There was decrease active cell phase angle combined comparison control 1.4 1.3 times, respectively (p<0.001). group, control, adipocytokine profile were significantly changed: resistin increased 1.5 leptin-binding receptor adiponectin reduced 1.6 (in cases, p<0.001). lower vitamin D levels other groups, also noted significant differences inflammation, oxidative stress, endothelial dysfunction. occurrence T/T rs4880 genotype SOD2 superoxide dismutase gene turned be characteristic carriage G/C rs20417 cyclooxygenase SOH2 did affect Conclusion. Comorbid realized conditions changes relation functional criteria, profile, systemic dysfunction, incidence polymorphic locus Ala16Val (rs4880) MnSOD (Superoxide Dismutase) gene. conducted study, taking into account correlation regression analysis results obtained, made it possible develop criteria disorders. Ethics. carried scientific research accordance standards Good Clinical Practice principles Helsinki Declaration. protocol approved Ethics Committee Novosibirsk State Medical University Ministry Health Russian Federation (Protocol No. 139 dated 11/25/2021). Before starting work, participants gave written informed voluntary consent participate study.

Language: Английский

---

Internal obesity as a risk factor for arterial hypertension

Russian Journal of Cardiology, Journal Year: 2019, Volume and Issue: 4, P. 7 - 12

Published: May 8, 2019

Aim. To assess the role of ultrasound parameters extent abdominal and epicardial visceral adipose tissue (VAT) as prognostic tools for determining probability arterial hypertension (AH) development in normotensive patients with obesity. Material methods. We studied 526 (according to results daily monitoring blood pressure (BP)) men (age 45,1±5,0 years) without cardiovascular diseases type 2 diabetes mellitus, a SCORE risk <5% obesity (waist circumference >94 cm). analyzed glycemia, lipid spectrum, creatinine urine albumin level. Echocardiography an assessment fat thickness (EFT), triplex scanning brachiocephalic arteries, VAT subcutaneous (SCF) were carried out. At end observational phase study (duration 46,3±5,1 months), repeated was performed. Results. Of 406 available patients, detected 157 (38,7%), including 72 (31,7%) initial age group 35-45 years 85 (47,5%) 46-55 years. These characterized by initially higher values EFT (5,2±0,7 mm vs 4,4±1,0 mm, p<0,001) ratio SCF (2,9±0,6 2,5±0,6, p<0,001). In individuals developed AH, incidence (58,0% 23,4%, p<0,001 44,6% 25,1%, p<0,001, respectively). Ultrasound ectopic (epicardial) included mathematical models AH high level statistical significance maximum standardized coefficients regression equations. Conclusion. Ultrasonic severity can be additional predicting people overweight

Language: Английский

---

Strategies and methods for the correction of obesity and associated cardiovascular risk

Russian Journal of Cardiology, Journal Year: 2019, Volume and Issue: 4, P. 61 - 67

Published: May 8, 2019

Today, there is a need to study obesity from the perspective of associated with it cardiovascular risk correcting. Future researches will have pathophysiology adipose tissue in greater detail, including tissue, cellular and molecular levels, order develop most effective strategies for therapeutic preventive measures. At same time, taking into account basic ideas about role cardiorespiratory fitness etiopathogenesis diseases, ratio fat free mass, white brown subcutaneous visceral main directions these measures becomes obvious. This article discusses correcting as part primary secondary prevention diseases suggests an algorithm developing individual program obese patient.

Language: Английский

---

Prognostic role of neutrophil gelatinase-associated lipocalin in patients with coronary artery disease and abdominal obesity

Russian Journal of Cardiology, Journal Year: 2023, Volume and Issue: 28(4), P. 5416 - 5416

Published: March 30, 2023

Aim . To study the prognostic role of neutrophil gelatinase-associated lipocalin (NGAL) as a marker adverse cardiovascular events (CVEs) in patients with coro­nary artery disease (CAD) associated abdominal obesity (AO). Material and methods This 12-month prospective included 68 diagnosed CAD who were hospitalized for elective percutaneous coronary intervention (PCI). The median age was 61 [55;65] years. Depending on presence according to World Health Organization (1999) criteria, divided into 2 groups. 1st group 30 AO, while 2nd — 38 without obesity. Patients measured waist circumference hip circumference, waist-to-hip ratio calculated. Lipid profile NGAL concentration determined. During study, body mass index (BMI), visceral adiposity (VAI), triglycerides (TG)/glucose index, lipid accumulation product (LAP), metabolic (MI), TG high-density lipoprotein cholesterol (HDL-C). this period, data collected course outcome. After 12 months an extended examination performed assess endpoints. Results follow-up unfavorable registered 33,3% patients, 26,3%. In obesity, higher values anthropometric indices established. has highest correlation BMI, MI, LAP slightly less total VAI levels. analysis showed that >47,1 ng/ml is predictor CVEs after PCI. Conclusion Thus, following indices: LAP, cholesterol, VAI. may serve promising predicting CVEs. biomarker already at stage hos­pitalization can risk outcomes including those underwent

Language: Английский

---

Predicting the risk of left ventricular diastolic dysfunction in obesity

Russian Journal of Cardiology, Journal Year: 2022, Volume and Issue: 27(4), P. 4811 - 4811

Published: Jan. 4, 2022

Obesity may develop heart failure with preserved ejection fraction, which is based on left ventricular diastolic dysfunction (LV DD). Currently, the search for effective predictors of LV DD extremely relevant. Aim . To assess prognostic value key and additional metabolic risk factors (RFs), neurohumoral profibrotic in development obese patients. Material methods The study included 149 men general obesity. mean age was 49,7±7,9 years. inclusion criteria presence class I-III average body mass index 32,9±3,6 kg/m2. exclusion were hypertension, coronary atherosclerosis, type 2 diabetes, as well according to transthoracic echocardiography. Depending epicardial adiposity, patients divided into two groups: group 1 — adipose tissue (EAT) thickness ≥7 mm (n=70), EAT <7 (n=31). In all patients, following laboratory parameters determined blood serum using enzyme immunoassay: I III collagen, Procollagen C-Terminal Propeptide (PICP), matrix metalloproteinase-3 (MMP-3), transforming growth factor β1, vascular endothelial factor, tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-10, C-reactive protein (CRP), adiponectin, soluble leptin receptor, leptin, lipid free fatty acids (FFA). After 4,7±0,3 years, echocardiography repeated order function. Results Comparative analysis revealed a significant increase level total cholesterol (p=0,001), low-density lipoprotein (LDL-C) (p<0,0001), triglycerides (TGs) (p<0,0001). These groups had no differences such high-density (p=0,09) glucose (p=0,12). An pro-inflammatory cytokines TNF-α CRP IL-6 (p<0,0001) revealed, while IL-10 (p=0,34) levels not significant. 1, there decrease adiponectin receptor (p=0,001). an studied revealed. that selected comparable A, E, E/A, E/e’, e’, peak tricuspid regurgitation velocity. There difference atrial volume (p=0,0003). detected 20 Binary logistic regression most patients: glucose, LDL-C, triglycerides, MMP-3, FFA, PICP, thickness. Conclusion Thus, identified

Language: Английский

---

The experience of sibutramine administration in patients with obesity and controlled arterial hypertension

Obesity and metabolism, Journal Year: 2019, Volume and Issue: 16(2), P. 42 - 48

Published: Sept. 16, 2019

BACKGROUND: Obesity is a metabolic disorder that becomes epidemic. Visceral adiposity increases the risk of arterial hypertension, diabetes mellitus and other comorbidities. According to this, main aim obesity treatment not only weight loss but also decrease AIMS: assess efficiency safety sibutramine in patients with evaluate drug influence on epicardial fat thickness. MATERIALS AND METHODS: 57 aged 35-60 hypertension were included study. All at beginning after 7 months follow-up underwent complex examination including anthropometric measurement, ECG, office ambulatory blood pressure echocardiography. Patients controlled included. During first month given general recommendations. Then was added. Control visits held 1 6 follow-up. RESULTS: Women predominated among study participants. approved by measurements all patients. Most had impaired left ventricle geometry: concentric remodeling or hypertrophy. mild: 2 kg (less than 2%) average. Sibutramine for increased: 3.7 (more After administration consisted 8.6 (6.2%) echocardiography results indexed mass LV myocardium decreased more significantly women. Also this group significant thickness revealed. Adverse events revealed 26.3% The most frequent constipation (12.3%) dry mouth (10.6%). severity symptoms persisted then decreased, additional therapy required. CONCLUSIONS: promotes effective loss, influences adipose tissue distribution, decreases progress associated an safe can be used visceral hypertension.

Language: Английский

---