Macrophage Activation Syndrome in Viral Sepsis DOI Creative Commons

Despoina Papageorgiou,

Charalambos Gogos,

Karolina Akinosoglou

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(7), P. 1004 - 1004

Published: June 22, 2024

Macrophage activation syndrome (MAS) is a life-threatening systemic hyperinflammatory triggered by various infections, particularly viral autoimmune disorders, and malignancy. The condition characterized an increased production of proinflammatory cytokines resulting in cytokine storm has been associated with poor clinical outcomes. During the COVID-19 pandemic, patients severe manifestations developed features similar to those MAS, although these characteristics remained well defined within lung. Additionally, other infections including EBV, herpes family viruses, hepatitis influenza, HIV, hemorrhagic fevers can be complicated MAS. diagnosis management remain challenging due lack consensus on specific guidelines, especially among adult population. Currently, therapeutic options primarily rely medications that are typically used treat primary hemophagocytic lymphohistiocytosis, such as corticosteroids etoposide. In addition, cytokine-targeted therapies present promising treatment options. objective this review discuss emergence MAS context including, but not limited to, its occurrence COVID-19.

Language: Английский

Macrophage Activation Syndrome in Viral Sepsis DOI Creative Commons

Despoina Papageorgiou,

Charalambos Gogos,

Karolina Akinosoglou

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(7), P. 1004 - 1004

Published: June 22, 2024

Macrophage activation syndrome (MAS) is a life-threatening systemic hyperinflammatory triggered by various infections, particularly viral autoimmune disorders, and malignancy. The condition characterized an increased production of proinflammatory cytokines resulting in cytokine storm has been associated with poor clinical outcomes. During the COVID-19 pandemic, patients severe manifestations developed features similar to those MAS, although these characteristics remained well defined within lung. Additionally, other infections including EBV, herpes family viruses, hepatitis influenza, HIV, hemorrhagic fevers can be complicated MAS. diagnosis management remain challenging due lack consensus on specific guidelines, especially among adult population. Currently, therapeutic options primarily rely medications that are typically used treat primary hemophagocytic lymphohistiocytosis, such as corticosteroids etoposide. In addition, cytokine-targeted therapies present promising treatment options. objective this review discuss emergence MAS context including, but not limited to, its occurrence COVID-19.

Language: Английский

Citations

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