Identification of Key lncRNAs in Gout Under Copper Death and Iron Death Mechanisms: A Study Based on ceRNA Network Analysis and Random Forest Algorithm

Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: March 12, 2024

Language: Английский

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A novel 5-differentially expressed gene (DEG) signature predicting the prognosis in patients with metastatic liver malignancies and the prognostic and therapeutic potential of SPP1

International Journal of Clinical Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

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The proximity proteome of pre-40S pre-ribosomal particle components PNO1 and NOB1 using turboID proximity labeling technology

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149411 - 149411

Published: March 1, 2025

Language: Английский

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LncRNA SNHG1: A novel biomarker and therapeutic target in hepatocellular carcinoma

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149462 - 149462

Published: April 1, 2025

Language: Английский

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Updated review on analysis of long non-coding RNAs as emerging diagnostic and therapeutic targets in prostate cancers

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 196, P. 104275 - 104275

Published: Feb. 1, 2024

Language: Английский

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Ferroptosis-related exosomal non-coding RNAs: promising targets in pathogenesis and treatment of non-malignant diseases

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 7, 2024

Ferroptosis, an iron-dependent form of programmed cell death, introduces a novel perspective on cellular demise. This study investigates the regulatory network exosomal non-coding RNAs (ncRNAs), including miRNAs, circRNAs, and lncRNAs, in ferroptosis modulation. The primary goal is to examine pathological roles ferroptosis-related ncRNAs, particularly ischemic reperfusion injuries. research reveals intricate molecular interactions governing interplay between ncRNAs ferroptosis, elucidating their diverse different non-malignant contexts. Attention given impact diseases, cardiac, cerebral, liver, kidney injuries, as well lung, wound, neuronal Beyond theoretical exploration, provides insights into potential therapeutic applications, emphasizing significance mesenchymal stem cells (MSCs)-derived exosomes. Findings underscore pivotal role MSC-derived modulating responses related regulation, introducing cutting-edge dimension. recognition emphasizes importance exosomes crucial mediators with broad implications. Insights unveil promising avenues for targeted interventions, capitalizing providing comprehensive foundation future strategies.

Language: Английский

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β-Sitosterol alleviates the malignant phenotype of hepatocellular carcinoma cells via inhibiting GSK3B expression

Human Cell, Journal Year: 2024, Volume and Issue: 37(4), P. 1156 - 1169

Published: May 30, 2024

Abstract To explore the effects of β-Sitosterol upon hepatocellular carcinoma cell proliferation, apoptosis, migration, invasion, and epithelial–mesenchymal transition (EMT), to investigate underlying mechanism using network pharmacology. Human lines (Huh-7 HCCLM3) were expose gradient concentrations (5 μg/mL, 10 20 μg/mL). Cell viability proliferation assessed MTT, CCK-8, colony formation, EdU assays.Flow cytometry was employed evaluate cycle apoptosis. Scratch Transwell assays performed, respectively, detect migration invasion. The levels apoptosis-associated proteins (BAX, BCL2, cleaved caspase3) as well EMT-associated (E-cadherin, N-cadherin, Snail, Vimentin) detected in Huh-7 HCCLM3 Western blot analysis. drug target gene for screened via PubChem subsequently evaluated expression GSE112790 dataset. In addition, level glycogen synthase kinase 3 beta (GSK3B) within Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) database analyzed, along with its correlation survival outcomes patients carcinoma. diagnostic efficiency GSK3B by analyzing ROC curve. Subsequently, transfected overexpression vector then treated further validate association between β-Sitosterol. demonstrated a significantly elevated carcinoma, which could predict patients’ impaired prognosis based on GEO dataset TCGA database. inhibitor (CHIR-98014) notably inhibited promoted apoptosis arrest at G0/G1 phase cells. treatment efffects has been found enhance proliferative invasive capabilities Furthermore it observed that overexpression, obsear can partially reverse inhibitory effect hepatocellular. suppressed enhanced inhibiting expression.

Language: Английский

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Non-Coding RNAs as Key Regulators of Gasdermin-D Mediated Pyroptosis in Cancer Therapy

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 261, P. 155490 - 155490

Published: July 26, 2024

Language: Английский

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Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis

Biogerontology, Journal Year: 2024, Volume and Issue: 26(1)

Published: Nov. 15, 2024

Language: Английский

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The functional significance of circRNA/miRNA/mRNA interactions as a regulatory network in lung cancer biology

The International Journal of Biochemistry & Cell Biology, Journal Year: 2024, Volume and Issue: 169, P. 106548 - 106548

Published: Feb. 13, 2024

Language: Английский

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