Japanese Journal of Health Physics, Journal Year: 2023, Volume and Issue: 58(3), P. 182 - 193
Published: Nov. 1, 2023
0.1-1 Gy) ，さらに は低線量(< 0.
Mutation Research/Reviews in Mutation Research, Journal Year: 2025, Volume and Issue: unknown, P. 108531 - 108531
Published: Jan. 1, 2025
Language: Английский
Citations
4
Mutation Research/Reviews in Mutation Research, Journal Year: 2025, Volume and Issue: unknown, P. 108530 - 108530
Published: Jan. 1, 2025
Language: Английский
Citations
2
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 5, 2025
The circulatory system receives ionizing radiation at various dose rates. Given mounting epidemiological evidence of elevated risks for diseases the (DCS), International Commission on Radiological Protection recently recommended first ever threshold DCS. However, very little knowledge exists about whether effects differ with rates and among tissues system. Here, we investigated impact in carotid artery (CA) compared it aorta. CA was obtained from mice irradiated same total that delivered either acutely, 25 fractions, 100 fractions or chronically. underwent immunofluorescence histochemistry staining. Irradiation led to vascular damage, inflammation fibrosis CA. integrative analysis 14 prelesional endpoints revealed magnitude changes greater smaller much chronic irradiation, acute irradiation. Radiation responses aorta were qualitatively similar to, but quantitatively than those causes sparing enhancing protraction a manner is not simple function rate, radiosensitivity varies within
Language: Английский
Citations
1
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 5041 - 5041
Published: June 10, 2024
The traditional training methods in radiological hot laboratories involve significant challenges, including the risk of radiation exposure and development radiophobia among learners. Virtual reality (VR) presents an innovative educational solution by simulating realistic lab environments procedures without associated risks. This mixed-method study investigates efficacy VR enhancing cognitive retention practical skills reducing students. All participants (video cohorts) were given a pre-test, same-day post-test, after 1 month, 3 months. In 3-month test, 13% control group scored > 80%, 87% 80% (6.69-fold more significant). simulated real-world accurately than videos, resulting increased confidence safety. Resulting training), decreased 1.52-fold; contrast, reduced 2.42-fold. These reductions indicate that was significantly effective video training. enhanced knowledge retention, radiophobia, safety confidence, fear about pursuing career nuclear medicine. Overall, created safer working environment, RT students responded positively instruction videos. Consequently, revealed key codes engagement, easy understanding, memory, safety, learning experiences, implementation curriculum, getting ready for clinical practice.
Language: Английский
Citations
5
International Journal of Radiation Biology, Journal Year: 2024, Volume and Issue: 100(4), P. 505 - 526
Published: Jan. 5, 2024
Purpose The discovery of X-rays was followed by a variety attempts to treat infectious diseases and various other non-cancer with ionizing radiation, in addition cancer. There has been recent resurgence interest the use such radiotherapy for diseases. Non-cancer which currently proposed include refractory ventricular tachycardia, neurodegenerative (e.g. Alzheimer's disease dementia), Coronavirus Disease 2019 (COVID-19) pneumonia, all ongoing clinical studies that deliver radiation doses 0.5–25 Gy single fraction or multiple daily fractions. In effects, historical indications predominantly used some countries Germany) osteoarthritis degenerative bones joints. This narrative review gives an overview biological rationale preclinical diseases, discusses plausibility rationale, considers long-term risks cancer
Language: Английский
Citations
4
Annales des Mines - Responsabilité et environnement, Journal Year: 2025, Volume and Issue: n° 117(1), P. 49 - 52
Published: Jan. 21, 2025
Citations
0
International Journal of Radiation Biology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24
Published: March 10, 2025
High-linear energy transfer (LET) radiation is generally thought to be more biologically effective in various tissues than low-LET radiation, but whether this also applies the circulatory system remains unclear. We therefore reviewed biological studies about effects of high-LET on system. identified 76 relevant papers (24 vitro, 2 ex vivo, 51 one overlapping). In vitro used human, bovine, porcine or chick vascular endothelial cells cardiomyocytes, while vivo hearts. mice, rats, rabbits, dogs pigs. The types were neutrons, α particles, heavy ions and negative pions. Most a single dose, although some investigated fractionation effects. Twenty-one estimated relative effectiveness (RBE) that ranged from 0.1 130, depending quality endpoint. A meta-analysis 6 8 (selected based feasibility estimating RBE its uncertainty) suggested an 6.69 (95% confidence intervals (CI): 2.51, 10.88) for 1.14 CI: 0.91, 1.37) studies. these 14 yielded 2.88 1.52, 4.25). This suggests only slightly substantial inter-study heterogeneity complicates interpretation. Therapeutic have been reported disease models. Further research needed better understand cardiovascular improve protection.
Language: Английский
Citations
0
Radiation Research, Journal Year: 2024, Volume and Issue: 202(6)
Published: Oct. 28, 2024
The study of One Million U.S. Radiation Workers and Veterans, the Person Study (MPS), examines health consequences, both cancer non-cancer, exposure to ionizing radiation received gradually over time. Recently MPS has focused on mortality patterns from neurological behavioral conditions, e.g., Parkinson's disease, Alzheimer's dementia, motor neuron disease such as amyotrophic lateral sclerosis. A fuller picture radiation-related late effects comes studying occurrence (incidence) conditions not leading death. Accordingly, is identifying neurocognitive diagnoses fee-for-service insurance claims Centers for Medicare Medicaid Services (CMS), among beneficiaries beginning in 1999 (the earliest date data are available). Linkages have identified ∼540,000 workers with available information. Such linkages provide individual information important co-factor confounding variables smoking, alcohol consumption, blood pressure, obesity, diabetes many other demographic characteristics. total person-level set time-dependent variables, outcomes, organ-specific dose measures, co-factors, demographics will be massive much too large evaluated standard software. Thus, development specialized open-source software designed datasets (Colossus) nearly complete. wealth CMS data, coupled reconstructions, thus greatly enhance quality precision evaluations this new field low-dose effects.
Language: Английский
Citations
3
International Journal of Radiation Biology, Journal Year: 2023, Volume and Issue: 100(1), P. 37 - 45
Published: July 31, 2023
Our previous work indicated the greater magnitude of damage to thoracic aorta at 6 months after starting 5 Gy irradiation in descending order exposure X-rays 25 fractions > acute γ-rays 100 ≫ chronic γ-rays, which limitations study included a lack data for fractionated γ-ray exposure. To better understand effects dose protraction and radiation quality, present examined changes fractions, compared its biological effectiveness with five other regimens.
Language: Английский
Citations
8
Journal of Radiation Research, Journal Year: 2024, Volume and Issue: 65(4), P. 500 - 506
Published: June 26, 2024
Abstract In the next decade, International Commission on Radiological Protection (ICRP) will issue set of general recommendations, for which evaluation relative biological effectiveness (RBE) various types tissue reactions would be needed. ICRP has recently classified diseases circulatory system (DCS) as a reaction, but not recommended RBE DCS. We therefore evaluated mean and uncertainty DCS by applying microdosimetric kinetic model specialized estimation reactions. For this purpose, we analyzed several data determined past animal experiments radius subnuclear domain best fit to each experiment single free parameter included in model. Our analysis suggested that tends lower than skin reactions, their difference was borderline significant due large variances parameters. also found following mono-energetic neutron irradiation human body is much particularly at thermal energy around 1 MeV. This tendency considered attributable only intrinsic between contributions secondary γ-rays total absorbed doses target organs. These findings help determine preventing
Language: Английский
Citations
2