Advanced Drug Delivery Reviews,
Journal Year:
2021,
Volume and Issue:
178, P. 113965 - 113965
Published: Sept. 8, 2021
Renal
microvascular
disease
associated
with
diabetes
[Diabetic
kidney
-
DKD]
is
the
leading
cause
of
chronic
disease.
In
DKD,
glomerular
basement
membrane
thickening,
mesangial
expansion,
endothelial
dysfunction,
podocyte
cell
loss
and
renal
tubule
injury
contribute
to
progressive
glomerulosclerosis
tubulointerstitial
fibrosis.
Chronic
inflammation
recognized
as
a
major
pathogenic
mechanism
for
resident
circulating
immune
cells
interacting
local
populations
provoke
an
inflammatory
response.
The
onset
driven
by
release
well
described
proinflammatory
mediators,
this
typically
followed
resolution
phase.
Inflammation
achieved
through
bioactions
endogenous
specialized
pro-resolving
lipid
mediators
(SPMs).
As
our
understanding
SPMs
advances
'resolution
pharmacology'
based
approaches
using
these
molecules
are
being
explored
in
DKD.
Journal of Clinical Investigation,
Journal Year:
2023,
Volume and Issue:
133(4)
Published: Feb. 14, 2023
Kidney
disease
is
a
major
driver
of
mortality
among
patients
with
diabetes
and
diabetic
kidney
(DKD)
responsible
for
close
to
half
all
chronic
cases.
DKD
usually
develops
in
genetically
susceptible
individual
as
result
poor
metabolic
(glycemic)
control.
Molecular
genetic
studies
indicate
the
key
role
podocytes
endothelial
cells
driving
albuminuria
early
diabetes.
Proximal
tubule
changes
show
strong
association
glomerular
filtration
rate.
Hyperglycemia
represents
cellular
stress
by
altering
metabolism
imposing
an
excess
workload
requiring
energy
oxygen
proximal
cells.
Changes
induce
adaptive
hypertrophy
reorganization
actin
cytoskeleton.
Later,
mitochondrial
defects
contribute
increased
oxidative
activation
inflammatory
pathways,
causing
progressive
function
decline
fibrosis.
Blockade
renin-angiotensin
system
or
sodium-glucose
cotransporter
associated
protection
slowing
decline.
Newly
identified
molecular
pathways
could
provide
basis
development
much-needed
novel
therapeutics.
Kidney International,
Journal Year:
2022,
Volume and Issue:
101(6), P. 1126 - 1141
Published: April 21, 2022
Numerous
genes
for
monogenic
kidney
diseases
with
classical
patterns
of
inheritance,
as
well
complex
that
manifest
in
combination
environmental
factors,
have
been
discovered.
Genetic
findings
are
increasingly
used
to
inform
clinical
management
nephropathies,
and
led
improved
diagnostics,
disease
surveillance,
choice
therapy,
family
counseling.
All
these
steps
rely
on
accurate
interpretation
genetic
data,
which
can
be
outpaced
by
current
rates
data
collection.
In
March
2021,
Kidney
Diseases:
Improving
Global
Outcomes
(KDIGO)
held
a
Controversies
Conference
"Genetics
Chronic
Disease
(CKD)"
review
the
state
understanding
(polygenic)
diseases,
processes
applying
medicine,
use
genomics
defining
stratifying
CKD.
Given
important
contribution
variants
CKD,
practitioners
CKD
patients
advised
"think
genetic,"
specifically
involves
obtaining
history,
collecting
detailed
information
age
onset,
performing
examination
extrarenal
symptoms,
considering
testing.
To
improve
genetics
nephrology,
meeting
participants
developing
an
advanced
training
or
subspecialty
track
nephrologists,
crafting
guidelines
testing
treatment,
educating
patients,
students,
practitioners.
Key
areas
future
research,
including
genome
variation,
electronic
phenotyping,
global
representation,
kidney-specific
molecular
polygenic
scores,
translational
epidemiology,
open
resources,
were
also
identified.
Cell Metabolism,
Journal Year:
2023,
Volume and Issue:
35(4), P. 695 - 710.e6
Published: March 23, 2023
Associations
between
human
genetic
variation
and
clinical
phenotypes
have
become
a
foundation
of
biomedical
research.
Most
repositories
these
data
seek
to
be
disease-agnostic
therefore
lack
disease-focused
views.
The
Type
2
Diabetes
Knowledge
Portal
(T2DKP)
is
public
resource
datasets
genomic
annotations
dedicated
type
diabetes
(T2D)
related
traits.
Here,
we
make
the
T2DKP
more
accessible
prospective
users
useful
existing
users.
First,
evaluate
T2DKP's
comprehensiveness
by
comparing
its
with
those
other
repositories.
Second,
describe
how
researchers
unfamiliar
can
begin
using
correctly
interpreting
them
via
T2DKP.
Third,
extend
their
current
workflows
use
full
suite
tools
offered
We
finally
discuss
lessons
toward
goal
democratizing
access
complex
disease
results.
Endocrine Reviews,
Journal Year:
2023,
Volume and Issue:
45(2), P. 227 - 252
Published: Aug. 25, 2023
Chronic
complications
of
diabetes
are
due
to
myriad
disorders
numerous
metabolic
pathways
that
responsible
for
most
the
morbidity
and
mortality
associated
with
disease.
Traditionally,
divided
into
those
microvascular
macrovascular
origin.
We
suggest
revising
this
antiquated
classification
vascular,
parenchymal,
hybrid
(both
vascular
parenchymal)
tissue
origin,
since
profile
ranges
from
involving
only
tissues
mostly
parenchymal
organs.
A
major
paradigm
shift
has
occurred
in
recent
years
regarding
pathogenesis
complications,
which
focus
shifted
studies
on
risks
interplay
between
risk
protective
factors.
While
factors
clearly
important
development
chronic
diabetes,
have
established
equally
significant
modulating
severity
complications.
These
responses
may
help
explain
differential
even
lack
pathologies,
some
tissues.
Nevertheless,
despite
growing
number
field,
comprehensive
reviews
their
mechanisms
action
not
available.
This
review
thus
focused
clinical,
biochemical,
molecular
support
idea
endogenous
factors,
roles
initiation
progression
diabetes.
In
addition,
also
aimed
identify
main
needs
field
future
studies.