A retrospective analysis of acute kidney injury in children with post-COVID-19 multisystem inflammatory syndrome: insights into promising outcomes DOI Creative Commons

Hanan El-Halaby,

Riham Eid,

Ahmed Elagamy

et al.

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Journal Year: 2024, Volume and Issue: 50(1)

Published: Feb. 5, 2024

Abstract Background Acute kidney injury (AKI) in patients with multisystem inflammatory syndrome (MIS), COVID-19 related infection has been increasingly recognized a paucity of data on AKI incidence, mortality, and the requirement renal replacement therapy children MIS (MIS-C). Methods This is retrospective study evaluating prevalence, severity, management outcomes cohort Egyptian MIS-children (MIS-C) post-COVID infection. Patients were included if they met criteria for MIS-C based CDC guidelines. All evaluated diagnosis staging according to Kidney Disease Improving Global Outcomes (KDIGO) criteria. Results Between March 2021 June 2023, total 655 confirmed cases admitted then followed up our hospital, whom 138 (21%) diagnosed MIS-C. Fifty-one developed associated infection, 42 analysis. Thirty-one had formerly healthy kidney, 51% (16 patients) classified as KDIGO stage 3, 5 needed hemodialysis 13 mechanical ventilation. Higher WBCs count, serum ferritin admission more severe (KDIGO 3) ( p = 0.04), while multivariate analysis showed high be independent predictor 0.02). Two (2/31) died during hospital admission, no residual impairment was reported at time discharge previously normal functions. Conclusion More than one-third develop AKI. Avoidance nephrotoxic drugs, early recognition, prompt AKI, including well-timed commencement dialysis cases, favorable outcomes.

Language: Английский

JAK inhibitor blocks COVID-19 cytokine–induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids DOI Creative Commons
Sarah Nystrom, Guojie Li,

Somenath Datta

et al.

JCI Insight, Journal Year: 2022, Volume and Issue: 7(11)

Published: April 26, 2022

COVID-19 infection causes collapse of glomerular capillaries and loss podocytes, culminating in a severe kidney disease called COVID-19–associated nephropathy (COVAN). The underlying mechanism COVAN is unknown. We hypothesized that cytokines induced by trigger expression pathogenic APOL1 via JAK/STAT signaling, resulting podocyte phenotype. Here, based on 9 biopsy-proven cases, we demonstrated for the first time, to best our knowledge, protein was abundantly expressed podocytes endothelial cells (GECs) kidneys but not controls. Moreover, majority patients with carried 2 risk alleles. show recombinant SARS-CoV-2 acted synergistically drive through pathway primary human GECs, micro-organoids derived from carrier alleles, blocked JAK1/2 inhibitor, baricitinib. demonstrate cytokine-induced JAK/STAT/APOL1 signaling reduced viability organoid rescued Together, results support conclusion COVID-19–induced are sufficient COVAN-associated podocytopathy JAK inhibitors could block this process. These findings suggest may have therapeutic benefits managing cytokine-induced, APOL1-mediated podocytopathy.

Language: Английский

Citations

39
COVID-19 and Glomerular Diseases DOI Creative Commons
Nattawat Klomjit, Ladan Zand, Lynn D. Cornell

et al.

Kidney International Reports, Journal Year: 2023, Volume and Issue: 8(6), P. 1137 - 1150

Published: March 27, 2023

Language: Английский

Citations

28
Kidney immunology from pathophysiology to clinical translation DOI
Christian Kurts, Sibylle von Vietinghoff, Christian F. Krebs

et al.

Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

Citations

1
COVID-19 and Kidney Disease DOI Creative Commons
Maureen Brogan, Michael J. Ross

Annual Review of Medicine, Journal Year: 2022, Volume and Issue: 74(1), P. 1 - 13

Published: Sept. 15, 2022

COVID-19 can cause acute kidney injury and may or exacerbate chronic diseases, including glomerular diseases. SARS-CoV-2 infection of cells has been reported, but it remains unclear if viral causes disease. The most important in patients with include impaired renal perfusion immune dysregulation. Chronic disease, especially failure replacement therapy transplant, is associated markedly increased mortality. Persons severe disease have excluded from clinical trials therapies, so therapeutic approaches must be extrapolated studies without Some medications used to treat should avoided at reduced dosages transplant recipients. Additional research needed determine the optimal strategies prevent

Language: Английский

Citations

34
Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement DOI Open Access
Evgeni Gusev, Alexey Sarapultsev

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6389 - 6389

Published: June 9, 2024

Long COVID (LC), also referred to as Post COVID-19 Condition, Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), and other terms, represents a complex multisystem disease persisting after the acute phase COVID-19. Characterized by myriad symptoms across different organ systems, LC presents significant diagnostic management challenges. Central disorder is role low-grade inflammation, non-classical inflammatory response that contributes chronicity diversity observed. This review explores pathophysiological underpinnings LC, emphasizing importance inflammation core component. By delineating pathogenetic relationships clinical manifestations this article highlights necessity for an integrated approach employs both personalized medicine standardized protocols aimed at mitigating long-term consequences. The insights gained not only enhance our understanding but inform development therapeutic strategies could be applicable chronic conditions with similar features.

Language: Английский

Citations

8
The changing landscape of HIV-associated kidney disease DOI
Nina Diana, Saraladevi Naicker

Nature Reviews Nephrology, Journal Year: 2024, Volume and Issue: 20(5), P. 330 - 346

Published: Jan. 25, 2024

Language: Английский

Citations

6
APOL1 Nephropathy Risk Variants Through the Life Course: A Review DOI Creative Commons

Ai Itoku,

Jaya S. Isaac, Scott Wilson

et al.

American Journal of Kidney Diseases, Journal Year: 2024, Volume and Issue: 84(1), P. 102 - 110

Published: Feb. 9, 2024

Two variant alleles of the gene apolipoprotein L1 (APOL1), known as risk variants (RVs), are a major contributor to kidney disease burden in those African descent. The APOL1 protein contributes innate immunity and may protect against Trypanosoma, HIV, Salmonella, leishmaniasis. However, effects carrying 1 or more RVs contribute variety processes starting early utero can be exacerbated by other factors (or "second hits"). Indeed, these genetic variations interact with environmental exposures, infections, systemic modify health outcomes across life span. This review focuses on APOL1-associated diseases through life-course perspective discusses how exposure second hits impact long-term outcomes. APOL1-related typically presents adolescents young adults, individuals harboring likely progress failure than who lack APOL-1 RVs. Ongoing research is aimed at elucidating association RV adverse donor recipient transplant Unfortunately, there currently no established treatment for nephropathy. Long-term needed evaluate protective associated different stages life.

Language: Английский

Citations

5
Spectrum of Kidney Injury Following COVID-19 Disease: Renal Biopsy Findings in a Single Italian Pathology Service DOI Creative Commons
Alessandro Gambella, Antonella Barreca, Luigi Biancone

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(2), P. 298 - 298

Published: Feb. 12, 2022

The onset of coronavirus disease (COVID-19) as a pandemic infection, has led to increasing insights on its pathophysiology and clinical features being revealed, such noticeable kidney involvement. In this study, we describe the histopathological, immunofluorescence, ultrastructural biopsy-proven injury observed in series SARS-CoV-2 positive cases our institution from April 2020 November 2021. We retrieved retrospectively reviewed nine (two pediatric seven adults) that experienced nephrotic syndrome (six cases), acute clinically silent microhematuria leukocyturia. Kidney biopsies were investigated by means light microscopy, direct electron microscopy. primary diagnoses minimal change (four tubular necrosis collapsing glomerulopathy C3 (one case). None showed viral or viral-like particles analysis. Novel specific histologic biopsy related infection have been gradually disclosed reported, harboring relevant therapeutic implications. Recognizing properly diagnosing renal involvement patients experiencing COVID-19 could be challenging (due lack proof e.g., particles) requires proper integration pathological data.

Language: Английский

Citations

22
Targeting WIP1 phosphatase promotes partial remission in experimental collapsing glomerulopathy DOI Creative Commons

Lou C. Duret,

Tynhinane Hamidouche,

Nicholas J. Steers

et al.

Kidney International, Journal Year: 2024, Volume and Issue: 105(5), P. 980 - 996

Published: Feb. 27, 2024

Collapsing focal segmental glomerulosclerosis (FSGS), also known as collapsing glomerulopathy (CG), is the most aggressive variant of FSGS and characterized by a rapid progression to kidney failure. Understanding CG pathogenesis represents key step for development targeted therapies. Previous work implicated telomerase protein component TERT in pathogenesis, transgenic expression adult mice resulted resembling that seen human primary HIV-associated nephropathy (HIVAN). Here, we used telomerase-induced mouse model (i-TERTci mice) identify mechanisms inhibit pathogenesis. Inactivation WIP1 phosphatase, p53 target acting negative feedback loop, blocked disease initiation i-TERTci mice. Repression upon deficiency was associated with senescence enhancement required transforming growth factor-β functions. The efficacy pharmacologic treatment reduce severity both HIVAN (Tg26 then assessed. Pharmacologic inhibition enzymatic activity either or Tg26 promoted partial remission proteinuria ameliorated histopathologic features. Histological well high-throughput sequencing methods further showed selective does not promote fibrosis inflammation. Thus, our findings suggest targeting may be an effective therapeutic strategy patients CG.

Language: Английский

Citations

4
Kidney damage associated with COVID-19: from the acute to the chronic phase DOI Creative Commons
Yannick Mayamba Nlandu, Elliot Koranteng Tannor,

Titilope Bafemika

et al.

Renal Failure, Journal Year: 2024, Volume and Issue: 46(1)

Published: April 1, 2024

Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) infection is well established as a systemic disease including kidney damage. The entry point into the renal cell remains angiotensin-converting enzyme 2 (ACE-2) receptor and spectrum of lesions broad, with clear predominance structural functional tubular lesions. most common form glomerular injury collapsing glomerulopathy (CG), which strongly associated apolipoprotein L1(APOL-1) risk variants. These lesions, are secondary to direct or indirect effects SARS-CoV-2, can progress chronicity specific long COVID-19 in absence any other cause. Residual inflammation SARS-CoV-2 infection, addition (AKI) transitional state without severe histological may be responsible for greater function decline mild-to-moderate COVID-19. This review discusses evidence markers patients triggers low-grade that explain post-COVID-19 period.

Language: Английский

Citations

4