The Italian Journal of Pediatrics/Italian journal of pediatrics,
Journal Year:
2024,
Volume and Issue:
50(1)
Published: Feb. 5, 2024
Abstract
Background
Acute
kidney
injury
(AKI)
in
patients
with
multisystem
inflammatory
syndrome
(MIS),
COVID-19
related
infection
has
been
increasingly
recognized
a
paucity
of
data
on
AKI
incidence,
mortality,
and
the
requirement
renal
replacement
therapy
children
MIS
(MIS-C).
Methods
This
is
retrospective
study
evaluating
prevalence,
severity,
management
outcomes
cohort
Egyptian
MIS-children
(MIS-C)
post-COVID
infection.
Patients
were
included
if
they
met
criteria
for
MIS-C
based
CDC
guidelines.
All
evaluated
diagnosis
staging
according
to
Kidney
Disease
Improving
Global
Outcomes
(KDIGO)
criteria.
Results
Between
March
2021
June
2023,
total
655
confirmed
cases
admitted
then
followed
up
our
hospital,
whom
138
(21%)
diagnosed
MIS-C.
Fifty-one
developed
associated
infection,
42
analysis.
Thirty-one
had
formerly
healthy
kidney,
51%
(16
patients)
classified
as
KDIGO
stage
3,
5
needed
hemodialysis
13
mechanical
ventilation.
Higher
WBCs
count,
serum
ferritin
admission
more
severe
(KDIGO
3)
(
p
=
0.04),
while
multivariate
analysis
showed
high
be
independent
predictor
0.02).
Two
(2/31)
died
during
hospital
admission,
no
residual
impairment
was
reported
at
time
discharge
previously
normal
functions.
Conclusion
More
than
one-third
develop
AKI.
Avoidance
nephrotoxic
drugs,
early
recognition,
prompt
AKI,
including
well-timed
commencement
dialysis
cases,
favorable
outcomes.
JCI Insight,
Journal Year:
2023,
Volume and Issue:
8(10)
Published: April 11, 2023
Viral
illnesses
like
SARS-CoV-2
have
pathologic
effects
on
nonrespiratory
organs
in
the
absence
of
direct
viral
infection.
We
injected
mice
with
cocktails
rodent
equivalents
human
cytokine
storms
resulting
from
SARS-CoV-2/COVID-19
or
rhinovirus
common
cold
At
low
doses,
COVID-19
induced
glomerular
injury
and
albuminuria
zinc
fingers
homeoboxes
2
(Zhx2)
hypomorph
Zhx2+/+
to
mimic
COVID-19-related
proteinuria.
Common
Cold
cocktail
selectively
Zhx2
model
relapse
minimal
change
disease,
which
improved
after
depletion
TNF-α,
soluble
IL-4Rα,
IL-6.
The
state
increased
cell
membrane
nuclear
migration
podocyte
ZHX
proteins
vivo
(both
cocktails)
lowered
phosphorylated
STAT6
activation
(COVID-19
cocktail)
vitro.
higher
acute
heart
injury,
myocarditis,
pericarditis,
liver
kidney
high
mortality
mice,
whereas
were
relatively
protected,
due
part
early,
asynchronous
STAT5
pathways
these
organs.
Dual
combinations
TNF-α
IL-2,
IL-13,
IL-4
reduced
multiorgan
eliminated
mortality.
Using
genome
sequencing
CRISPR/Cas9,
an
insertion
upstream
ZHX2
was
identified
as
a
cause
state.
Annals of Medicine and Surgery,
Journal Year:
2023,
Volume and Issue:
85(2), P. 92 - 101
Published: Feb. 1, 2023
The
renal
system
manifestations
of
coronavirus
disease-2019
have
been
documented
extensively;
however,
scientific
literature
remains
scarce
regarding
collapsing
glomerulopathy
hence
the
need
for
this
investigation.
Journal of Medical Virology,
Journal Year:
2022,
Volume and Issue:
95(1)
Published: Nov. 15, 2022
Abstract
Coronavirus
disease
2019
(COVID‐19)
can
cause
damage
to
multiple
organ,
not
only
the
lungs,
but
also
kidneys.
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2)
and
chronic
kidney
through
direct
viral
infection,
indirect
injury,
vaccination‐related
injury.
Like
lung
injury
is
an
important
aspect
affecting
severity
prognosis
of
SARS‐CoV‐2.
This
article
summarizes
pathogenesis,
pathological
manifestations,
clinical
features
SARS‐CoV‐2
or
renal
Including
special
comorbidities
(receiving
transplantation
disease),
vaccine‐related
exploring
possible
therapeutic
effect
anti‐SARS‐CoV‐2
therapy
on
The
purpose
provide
reference
for
understanding
COVID‐19‐related
guiding
diagnosis
treatment,
evaluating
prognosis.
The Italian Journal of Pediatrics/Italian journal of pediatrics,
Journal Year:
2024,
Volume and Issue:
50(1)
Published: Feb. 5, 2024
Abstract
Background
Acute
kidney
injury
(AKI)
in
patients
with
multisystem
inflammatory
syndrome
(MIS),
COVID-19
related
infection
has
been
increasingly
recognized
a
paucity
of
data
on
AKI
incidence,
mortality,
and
the
requirement
renal
replacement
therapy
children
MIS
(MIS-C).
Methods
This
is
retrospective
study
evaluating
prevalence,
severity,
management
outcomes
cohort
Egyptian
MIS-children
(MIS-C)
post-COVID
infection.
Patients
were
included
if
they
met
criteria
for
MIS-C
based
CDC
guidelines.
All
evaluated
diagnosis
staging
according
to
Kidney
Disease
Improving
Global
Outcomes
(KDIGO)
criteria.
Results
Between
March
2021
June
2023,
total
655
confirmed
cases
admitted
then
followed
up
our
hospital,
whom
138
(21%)
diagnosed
MIS-C.
Fifty-one
developed
associated
infection,
42
analysis.
Thirty-one
had
formerly
healthy
kidney,
51%
(16
patients)
classified
as
KDIGO
stage
3,
5
needed
hemodialysis
13
mechanical
ventilation.
Higher
WBCs
count,
serum
ferritin
admission
more
severe
(KDIGO
3)
(
p
=
0.04),
while
multivariate
analysis
showed
high
be
independent
predictor
0.02).
Two
(2/31)
died
during
hospital
admission,
no
residual
impairment
was
reported
at
time
discharge
previously
normal
functions.
Conclusion
More
than
one-third
develop
AKI.
Avoidance
nephrotoxic
drugs,
early
recognition,
prompt
AKI,
including
well-timed
commencement
dialysis
cases,
favorable
outcomes.
