Unveiling the impact of CD133 on cell cycle regulation in radio- and chemo-resistance of cancer stem cells DOI Creative Commons

Luyao Wu,

Takanori Katsube, Xiaofei Li

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 6, 2025

The adaptation of malignancy to therapy presents a significant challenge in cancer treatment. cell cycle plays crucial role regulating the evolution radio- and chemo-resistance tumor cells. Cancer stem cells (CSCs) are primary source resistance, with CD133 being one most recognized valuable surface markers CSCs. Evidence increasingly suggests that is associated resistance. current understanding molecular biological function limited, leading ongoing debates about its biology. In this review, we explore recent research emerging trends related through extensive literature content analysis. It was summarized new insights into relationships signaling pathways resistant aim review provide foundational how these their interactions impact prognosis inform treatment strategies.

Language: Английский

Unveiling the impact of CD133 on cell cycle regulation in radio- and chemo-resistance of cancer stem cells DOI Creative Commons

Luyao Wu,

Takanori Katsube, Xiaofei Li

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 6, 2025

The adaptation of malignancy to therapy presents a significant challenge in cancer treatment. cell cycle plays crucial role regulating the evolution radio- and chemo-resistance tumor cells. Cancer stem cells (CSCs) are primary source resistance, with CD133 being one most recognized valuable surface markers CSCs. Evidence increasingly suggests that is associated resistance. current understanding molecular biological function limited, leading ongoing debates about its biology. In this review, we explore recent research emerging trends related through extensive literature content analysis. It was summarized new insights into relationships signaling pathways resistant aim review provide foundational how these their interactions impact prognosis inform treatment strategies.

Language: Английский

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