Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1734 - 1734
Published: Aug. 2, 2024
The study aimed to evaluate the efficacy of percutaneous dilatational tracheostomy (PDT) combined with adjuvant therapies in preserving vocal function amyotrophic lateral sclerosis (ALS) patients.
Language: Английский
Cells, Journal Year: 2024, Volume and Issue: 13(10), P. 790 - 790
Published: May 7, 2024
Translational research in neurological and psychiatric diseases is a rapidly advancing field that promises to redefine our approach these complex conditions [...]
Language: Английский
Citations
19
Published: April 17, 2024
The editorial explores the realm of emerging translational research in neurology and psychiatry, providing insights into various subjects, including neurodegenerative disorders innovative therapeutic methods. main objective is to study neurological psychiatric disorders, such as Alzheimer's disease, with a particular emphasis on techniques for neural regeneration repair. highlights importance taking comprehensive approach studying treating complex conditions. This involves thoroughly reviewing papers causes, development, biomarkers, treatment options these emphasizes necessity using multidisciplinary integrative methods gain deeper understanding improve development an animal model recurrent primary dysmenorrhea showcases employed investigation gynecological illustrating capacity connect fundamental scientific knowledge practical medical applications. cooperative endeavors researchers clinicians emphasized this lay foundation revolutionary advancements that hold potential enhance outcomes individuals afflicted globally.
Language: Английский
Citations
17
Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1083 - 1083
Published: May 13, 2024
Welcome to
Language: Английский
Citations
17
Cells, Journal Year: 2024, Volume and Issue: 13(13), P. 1098 - 1098
Published: June 25, 2024
Migraine is a debilitating neurological disorder characterized by recurring episodes of throbbing headaches that are frequently accompanied sensory disturbances, nausea, and sensitivity to light sound [...]
Language: Английский
Citations
13
Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 701 - 701
Published: June 7, 2024
With neurodegenerative disorders being on the rise, a great deal of research from multiple fields is conducted in order to further knowledge and propose novel therapeutic interventions. Among these investigations, role antioxidants contrasting cognitive decline putting forward interesting promising results. In this review, we aim collect evidence that focused variety antioxidant-rich foods improving or stabilizing functions, memory, Alzheimer’s disease, most common disorder. Specifically, considered collected humans, either through longitudinal studies randomized, placebo-controlled ones, which evaluated performance, memory abilities, progression level neurodegeneration. Overall, despite between study protocols, cohorts participants involved, neuropsychological tests used, investigated antioxidants, there solid trend suggests properties may be helpful hampering older people. Thus, help future will elucidate neuroprotection lead development interventions take into account such findings provide more global approach treating disorders.
Language: Английский
Citations
12
Behaviour Research and Therapy, Journal Year: 2024, Volume and Issue: 178, P. 104548 - 104548
Published: April 28, 2024
It is still unclear how the human brain consolidates aversive (e.g., traumatic) memories and whether this process can be disrupted. We hypothesized that dorsolateral prefrontal cortex (dlPFC) crucially involved in threat memory consolidation. To test this, we used low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) within stabilization time window to disrupt expression of memory. combined a differential threat-conditioning paradigm with LF-rTMS targeting dlPFC critical condition, occipital stimulation, delayed sham as control conditions. In defensive reactions were reduced immediately after 1 h 24 later. stark contrast, no decrease was observed conditions, thus showing both anatomical temporal specificity our intervention. provide causal evidence selectively early consolidation period prevents persistence return conditioned responses. Furthermore, disruption lasted longer than inhibitory created by TMS protocol, which suggests influenced neural activity hampered underlying, time-dependent process. These results important insights for future clinical applications aimed at interfering aversive, threat-related memories.
Language: Английский
Citations
10
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 15, 2025
Heart rate variability (HRV) is a widely recognized biomarker for autonomic nervous system regulation, applicable in clinical and athletic settings to monitor health recovery. Despite its extensive use, HRV measurement reliability influenced by numerous factors, necessitating controlled conditions accurate assessments. This study investigates the of short-term measurements various positions, aiming establish consistent protocols monitoring interpretation. We assessed morning 34 healthy, physically active adults across supine standing at home laboratory, over 24-hour period. Environment significantly impacted HRV. Home exhibited slightly lower variance compared lab settings, underscoring importance environment control. Our findings confirm high measurements, indicating their robustness capturing changes, provided rigorous methodology employed. Here we show that effective reliable assessment possible conditions, contingent upon strict management confounding factors. research supports utility as non-invasive diagnostic tool, emphasizing potential broadening applications diverse populations. Future studies are encouraged expand these assessments include varied demographic profiles, enhancing integration into routine evaluations.
Language: Английский
Citations
1
Annals of the New York Academy of Sciences, Journal Year: 2024, Volume and Issue: 1536(1), P. 151 - 166
Published: May 15, 2024
Abstract Swiftly halting ongoing motor actions is essential to react unforeseen and potentially perilous circumstances. However, the neural bases subtending complex interplay between emotions control have been scarcely investigated. Here, we used an emotional stop signal task (SST) investigate whether specific circuits engaged by action suppression are differently modulated signals with respect neutral ones. Participants performed SST before after administration of one session repetitive transcranial magnetic stimulation (rTMS) over pre‐supplementary cortex (pre‐SMA), right inferior frontal gyrus (rIFG), left primary (lM1). Results show that rTMS pre‐SMA improved ability inhibit prepotent (i.e., better control) when stimuli were presented. In contrast, in a context was fostered rIFG. No changes observed lM1 stimulation. Intriguingly, individuals higher impulsivity traits exhibited enhanced facing following rIFG These results further our understanding functions, shedding light on selective modulation pathways underpinning these processes.
Language: Английский
Citations
6
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(11), P. 3026 - 3026
Published: May 21, 2024
Background/Objectives: The anxiolytic effect of transcutaneous electrical nerve stimulation (TENS) is associated with the activation endogenous inhibitory mechanisms in central nervous system. Both low-frequency, high-amplitude TENS (LF-TENS) and high-frequency, low-amplitude (HF-TENS) are capable activating opioid, GABA, serotonin, muscarinic, cannabinoid receptors. However, there has been no comparative analysis effectiveness HF-TENS LF-TENS treatment GAD. purpose our research was to study direct right median patients GAD compared sham TENS. Methods: studied using Generalized Anxiety Disorder 7-item scale (GAD-7) Hamilton Rating Scale (HAM-A). 40 underwent TENS, passed (50 Hz—50 μs—sensory response) 41 completed LF –TENS (1 Hz—200 μs—motor for 30 days daily. After completion treatment, half received weekly maintenance therapy 6 months. Electroencephalography performed before after treatment. Results: Our showed that a significant reduction clinical symptoms as assessed by GAD-7 HAM-A observed an average 42.4%, only 13.5% at least 2 months end turned out be superior 51% on electroencephalography leads increase PSD alpha rhythm occipital regions 24% decrease beta I temporal frontal 28%. prolonged maintained without negative dynamics when continued throughout entire six-month observation period. Conclusions: A proven greater regression neurophysiological manifestations HF-TENS. Minimal side effects, low cost, safety, simplicity procedures appropriate home modality.
Language: Английский
Citations
5
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12767 - 12767
Published: Nov. 27, 2024
The tryptophan-kynurenine (KYN) pathway has long been recognized for its essential role in generating metabolites that influence various physiological processes. Traditionally, these have categorized into distinct, often opposing groups, such as pro-oxidant versus antioxidant, excitotoxic/neurotoxic neuroprotective. This dichotomous framework shaped much of the research on conditions like neurodegenerative and neuropsychiatric disorders, well cancer, where metabolic imbalances are a key feature. effects significantly influenced by factors, including concentration particular cellular milieu which they generated. A molecule acts neuroprotective at low concentrations may exhibit neurotoxic elevated levels. oxidative equilibrium surrounding environment can alter function KYN from an antioxidant to pro-oxidant. narrative review offers comprehensive examination analysis contemporary understanding metabolites, emphasizing their multifaceted biological functions relevance numerous pathological underscores pressing necessity paradigm shift comprehension metabolism. Understanding context-dependent roles is vital novel therapies Alzheimer's disease, multiple sclerosis, cancer. Comprehensive modulation, balancing inflammatory signals enzyme regulation, promising avenues targeted, effective treatments.
Language: Английский
Citations
4