Ukrainian journal of cardiovascular surgery,
Journal Year:
2023,
Volume and Issue:
31(1), P. 19 - 28
Published: March 27, 2023
The
aim.
To
study
the
impact
of
COVID-19
upon
intracardiac
hemodynamics
and
heart
rate
variability
(HRV)
in
stable
coronary
artery
disease
(SCAD)
patients.
Materials
methods.
In
this
cross-sectional
we
analyzed
clinical
instrumental
data
obtained
from
a
sample
80
patients.
patients
were
divided
into
three
groups:
group
1
included
with
SCAD
without
(n=30),
2
(n=25),
3
(n=25).
control
30
relatively
healthy
volunteers.
Results.
changes
HRV
characterized
by
impaired
left
ventricular
systolic
diastolic
function,
dilation
both
ventricles
elevated
pulmonary
pressure.
Left
end-diastolic
volume
was
higher
(205±21
ml)
than
that
(176±33
ml;
р<0.001)
(130±21
р<0.001).
Patients
groups
1–3,
compared
to
controls,
presented
decrease
overall
(by
standard
deviation
[SD]
all
NN
intervals
[SDNN];
SD
averages
5
min
segments
entire
recording;
mean
SDs
for
recording)
parasympathetic
activity
(root-mean-square
difference
successive
intervals;
proportion
derived
dividing
number
interval
differences
greater
50
ms
[NN50]
total
[pNN50],
high
frequency
spectral
component),
along
QT
prolongation
increase
its
variability.
Group
demonstrated
most
advanced
SDNN
pNN50)
characteristics.
Conclusions.
concomitant
COVID-19,
impairment,
sings
autonomic
dysfunction,
characteristics
should
be
additionally
considered
management
such
Turkish Journal of Biochemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 26, 2025
Abstract
Objectives
The
Pasteur
effect
in
cellular
energy
metabolism
is
defined
as
the
switch
to
anaerobic
glycolysis
due
alterations
ambient
oxygen
concentration
or
inhibition
of
electron
transport
chain
(ETC)
and
oxidative
phosphorylation.
This
study
aimed
determine
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2)
infection
on
leukocytes
among
Disease
2019
(COVID-19)
patients
at
various
stages.
Methods
A
total
90
cases
were
analyzed
asymptomatic,
mild,
moderate,
severe
COVID-19
patients.
Levels
aerobic
intermediates
products
measured
with
liquid
chromatography-tandem
mass
spectrometry
(LC-MS/MS)
analysis.
Results
decrease
rate
was
found
disease
progressed
(p-values<0.001),
while
unchanged
all
groups
because
lactate
levels
had
no
difference
between
(p=0.754).
Moreover,
ratios
Tricarboxylic
Acid
(TCA)
cycle
parameters
demonstrated
a
significant
reduction
different
stages
(p-values<0.001).
Furthermore,
Receiver
Operating
Characteristic
(ROC)
curve
analysis
for
citrate,
alpha-ketoglutarate,
fumarate,
lactate,
lactate/citrate,
lactate/alpha-ketoglutarate,
lactate/fumarate
cut-off
values
Moderate
(p<0.001).
Conclusions
Our
results
suggest
that
from
shown
be
induced
severity
progresses.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: April 3, 2025
SARS-CoV-2
infects
ACE2-negative
primary
HL-mECs
through
the
interaction
of
an
RGD
motif,
included
in
all
spike
proteins,
up
to
Omicron
BA.1
subvariant,
with
αvβ3
integrin.
Following
its
entry,
remodels
ECs
phenotype
and
promotes
angiogenesis
absence
productive
viral
replication.
Moreover,
lack
spike/αvβ3
interaction,
occurring
BA.5
which
contains
D405N
mutation
inhibits
infection
dysfunction.
It
is
worth
noting
that
anti-spike
antibodies
do
not
impact
entry
into
HL-mECs.
This
data
highlights
fact
i)
motif
exposed
entire
protein
ii)
need
a
cofactor
favoring
interaction.
HSPGs
are
used
by
different
viruses
as
receptors
coreceptors
for
their
host
cells.
Here,
we
use
approaches
scrutinize
role
exerted
ECs.
We
highlight
key
molecules
responsible
exposure
allowing
binding
integrin
first
step
toward
endocytosis.
Indeed,
SPR
analysis
showed
heparin.
was
further
corroborated
immunofluorescence
infectivity
assays.
Interestingly,
Heparinase
III
or
sodium
chlorate
counteracts
release
proangiogenic
signaling
pathways
induced
infection.
Thus,
may
represent
target
preventing
EC
dysfunction-related
COVID-19
severity.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 16, 2025
This
study
aims
to
identify
the
use
of
health
services
by
individuals
with
long
COVID
residing
in
South
Brazil
6
months
after
acute
phase
a
SARS-CoV-2
infection.
A
cross-sectional
cohort
who
survived
coronavirus
disease
was
conducted
Rio
Grande,
Brazil.
The
participants
were
asked
about
their
during
6-10
following
recovery
from
Data
on
overall
primary
healthcare
services,
general
practitioner
emergency
specialist
doctors'
and
specialized
collected.
Individuals
reported
more
frequent
than
those
without
COVID.
musculoskeletal,
neurological,
respiratory
symptoms
associated
whereas
digestive,
services.
Finally,
neurological
these
symptoms.
used
Participants
greater
number
fewer
Healthcare
depends
type
Health
need
be
reorganized
adapted
provide
adequate
treatment
care
people
BioScience Trends,
Journal Year:
2023,
Volume and Issue:
17(2), P. 85 - 116
Published: March 13, 2023
Over
three
years
have
passed
since
the
COVID-19
pandemic
started.
The
dangerousness
and
impact
of
should
definitely
not
be
ignored
or
underestimated.
Other
than
symptoms
acute
infection,
long-term
associated
with
SARS-CoV-2
which
are
referred
to
here
as
"sequelae
long
COVID
(LC)",
also
a
conspicuous
global
public
health
concern.
Although
such
sequelae
were
well-documented,
understanding
insights
regarding
LC-related
remain
inadequate
due
limitations
previous
studies
(the
follow-up,
methodological
flaws,
heterogeneity
among
studies,
etc.).
Notably,
robust
evidence
diagnosis
treatment
certain
LC
insufficient
has
been
stumbling
block
better
management
these
patients.
This
awkward
situation
motivated
us
conduct
this
review.
Here,
we
comprehensively
reviewed
updated
information,
particularly
focusing
on
clinical
issues.
We
attempt
provide
latest
information
by
systematically
reviewing
involvement
main
organ
systems.
propose
paths
for
future
exploration
based
available
knowledge
authors'
experience.
believe
that
take-home
messages
will
helpful
gain
into
ultimately
benefit
practice
in
treating
sequelae.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(7), P. 1863 - 1863
Published: June 29, 2023
Fatigue
and
dyspnoea
are
common
post-COVID
symptoms.
The
aim
of
this
study
was
to
apply
Sankey
plots
exponential
bar
for
visualizing
the
evolution
trajectory
fatigue
symptoms
in
a
cohort
previously
hospitalized
COVID-19
survivors.
A
total
1266
patients
due
participated
multicentre
study.
They
were
assessed
at
hospital
admission
(T0),
8.4
months
(T1),
13.2
(T2)
18.3
(T3)
after
discharge
asked
about
presence
self-reported
or
defined
as
self-perceived
feeling
constant
tiredness
and/or
weakness
whereas
shortness
breath
rest.
We
specifically
that
participants
attributed
infection.
Clinical/hospitalization
data
collected
from
medical
records.
prevalence
56.94%
(n
=
721)
T1,
52.31%
662)
T2
42.66%
540)
T3.
rest
decreased
28.71%
363)
21.29%
270)
13.96%
177)
12.04%
153)
revealed
469
(37.08%)
153
(12.04%)
exhibited
all
follow-up
periods.
recovery
curves
show
trend,
showing
recover
following
three
years
hospitalization.
regression
models
female
sex
experiencing
(e.g.,
fatigue,
dyspnoea)
T1
factors
associated
with
use
shows
fluctuating
during
first
two
In
addition,
these
after.
is
risk
factor
development
dyspnoea.
Viruses,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1134 - 1134
Published: May 10, 2023
This
multicenter
cohort
study
used
Sankey
plots
and
exponential
bar
to
visualize
the
fluctuating
evolution
trajectory
of
gastrointestinal
symptoms
in
previously
hospitalized
COVID-19
survivors
during
first
18
months
after
acute
SARS-CoV-2
infection.
A
total
1266
were
assessed
at
four
points:
hospital
admission
(T0),
8.4
(T1),
13.2
(T2),
18.3
(T3)
hospitalization.
Participants
asked
about
their
overall
particularly
diarrhea.
Clinical
hospitalization
data
collected
from
medical
records.
The
prevalence
post-COVID
symptomatology
was
6.3%
(n
=
80)
T1,
3.99%
50)
T2
2.39%
32)
T3.
diarrhea
decreased
10.69%
135)
2.55%
1.04%
14)
T2,
0.64%
8)
revealed
that
just
20
(1.59%)
4
(0.32%)
patients
exhibited
or
diarrhea,
respectively,
throughout
whole
follow-up
period.
recovery
fitted
curves
a
decreasing
trend,
showing
recover
two
three
years
survivors.
regression
models
did
not
reveal
any
be
associated
with
presence
T1.
use
In
addition,
