Clinical symptoms, comorbidities and complications in severe and non-severe patients with COVID-19

Medicine, Journal Year: 2020, Volume and Issue: 99(48), P. e23327 - e23327

Published: Nov. 23, 2020

The pandemic of COVID-19 poses a challenge to global healthcare. mortality rates severe cases range from 8.1% 38%, and it is particularly important identify risk factors that aggravate the disease.

Language: Английский

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Aspects of pharmacotherapy with steroids in SARS-CoV-2 infection (literature review)

Experimental and Clinical Medicine, Journal Year: 2024, Volume and Issue: 93(1), P. 25 - 33

Published: March 31, 2024

In recent years, the SARS-CoV-2 pandemic has posed a significant challenge to global public health. Furthermore, infection with can result in acute respiratory distress syndrome due excessive systemic inflammation, leading multiple organ failure and eventual death. of reducing specifically by decreasing production pro-inflammatory cytokines response SARS-CoV-2, remains unresolved. The use glucocorticosteroids for controversial. Further research is required support routine steroids intensive care protocols as current basis insufficient. This review provides an analysis literary sources, guidelines, modern international recommendations on pathogenetic therapy prevent eliminate hyperproduction using glucocorticosteroid agents. aim this work analyse contemporary sources clinical pharmacological justification practice infection. scientific literature indicates that cannot be recommended therapeutic patients Thus, mild course infection, when patient does not need oxygen support, are contraindicated. Whereas severe course, failure, their absolutely necessary, they mandatory use. There generalised definition optimal agent, including indications, dosage, duration programs. Keywords: inflammatory reaction, proinflammatory cytokines, hypothalamic-pituitary-adrenal system, glucocorticosteroids.

Language: Английский

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Clinical symptoms, comorbidities and complications features in severe and non-severe patients with COVID-19: a systematic review and meta-analysis without cases duplication

Research Square (Research Square), Journal Year: 2020, Volume and Issue: unknown

Published: May 29, 2020

Abstract Background: The pandemic of COVID-19 posed a challenge to global healthcare. mortality rates severe cases range from 8.1% 31.8%, and it is particularly important identify risk factors that aggravate the disease. Methods: We performed systematic review literature with meta-analysis, using 7 databases assess clinical characteristics, comorbidities complications in non-severe patients COVID-19. All observational studies were included. random or fixed effects model meta-analysis calculate pooled proportion 95% CI. Measure heterogeneity was estimated by Cochran’s Q statistic, I 2 index P value. Results: 4881 25 related most prevalent comorbidity hypertension (severe: 33.4%, CI: 25.4% - 41.4%; 21.6%, 9.9% 33.3%), followed diabetes 14.4%, 11.5% 17.3%; non-severe: 8.5%, 6.1% 11.0%). prevalence ARDS, AKI shock all higher cases, 41.1% (95% 14.1% 68.2%), 16.4% 3.4% 29.5%) 19.9% 5.5% 34.4%), rather than 3.0% 0.6% 5.5%), 2.2% 0.1% 4.2%) 4.1% CI -4.8% 13.1%) patients, respectively. death rate (30.3%, 13.8% 46.8%) (1.5%, 2.8%). Conclusions: Hypertension, cardiovascular diseases may be for develop into cases.

Language: Английский

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CLINICAL AND PHARMACOLOGICAL ASPECTS OF APPLYING GLUCOCORTICOSTEROIDS FOR SARS-COVID-2 INFECTION: REVIEW ARTICLE

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Journal Year: 2024, Volume and Issue: 24(1), P. 244 - 249

Published: March 20, 2024

In recent years, the SARS-CoV-2 pandemic has become one of unexpected and very serious challenges for public health around world. Moreover, infection led to development acute respiratory distress syndrome as a result excessive systemic inflammation, multiple organ failure, later death. problem eliminating that is, reducing production pro-inflammatory cytokines in SARS-CoV-2, remains open. this regard, use glucocorticosteroids caused by quite controversial. The basis routine steroids intensive care protocols is clearly insufficient subject further research. This review provides an analysis literary sources, guidelines, modern international recommendations on pathogenetic therapy prevent eliminate hyperproduction using glucocorticosteroid agents. purpose work conduct sources regarding features clinical pharmacological justification practice. scientific literature demonstrates today cannot be recommended therapeutic practice patients with infection. Thus, mild course infection, when patient does not need oxygen support, GCS contraindicated. With severe develops there therapy, mechanical ventilation or ECMO, corticosteroids extremely necessary, may mandatory use. There pressing comprehensive definition optimal agent, indications, dosage, duration programs. should done while considering biomarkers severity inflammatory process body's response

Language: Английский

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Lessons of the global COVID-19 pandemic in relation to the quality of education

Medicine Today and Tomorrow, Journal Year: 2024, Volume and Issue: 93(1), P. 14 - 24

Published: March 31, 2024

The global COVID-19 pandemic has had a profound impact on humanity, affecting not only physical health but also neurological, social, and ecological well-being. Neurological psychological disorders can negatively learning quality significantly worsen outcomes for higher education students. aim of this study is to compare the prevalence evaluate symptoms post-COVID-19 syndrome among senior students in two educational institutions, Poltava State Medical University National Pedagogical named after V.G. Korolenko. these will be assessed through analysis author's questionnaire. Rehabilitation measures recommended improve process. It been determined that there high level damage nervous system from both universities, which accompanied by combination including headache, memory impairment, insomnia, anxiety, unmotivated weakness, excessive fatigue. aforementioned complaints need increase time completing tasks illness, along with impairment sleep disturbances, suggest academic performance, state, psychosomatic background are at low level. Therefore, recommendations cognitive rehabilitation category applicants necessary, taking into account their significant load. samples were made year Physical activity levels may exacerbate symptoms. Recommendations patient group necessary. Applicants experiencing increased fatigue, reduced work capacity, mood instability should review organization process distance conditions make changes lifestyle. Keywords: syndrome, long COVID-19, trucker syndrome.

Language: Английский

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STRATEGIES TO MITIGATE THE IMPACT OF POST-COVID-19 SYNDROME ON HIGHER EDUCATION QUALITY

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Journal Year: 2024, Volume and Issue: 24(2), P. 200 - 206

Published: May 20, 2024

The SARS-CoV-2 pandemic has left a profound impact not only on the physical health of humanity but also neurological, social, and ecological well-being. Neurological psychological disorders resulting from have negatively affected quality learning significantly worsened outcomes among students in higher education institutions. purpose this study is to compare prevalence evaluate symptoms post-COVID syndrome, identify their senior two educational institutions: Poltava State Medical University National Pedagogical named after V.G. Korolenko. It been observed that damage nervous system simultaneous appearance combination including headache, memory impairment, insomnia, anxiety, unmotivated weakness, excessive fatigue are high both universities. aforementioned complaints, along with need for increased time complete tasks post-illness, sleep disturbances, indicate academic performance, state, psychosomatic background at low level. Therefore, it essential develop recommendations cognitive rehabilitation tailored group students, considering significant workload (samples were collected students). Moreover, moderate activity levels may exacerbate post-COVID-19 necessitating development rehabilitation. Students experiencing fatigue, reduced work capacity, mood instability should consider reviewing organization process, especially distance conditions, making lifestyle changes accordingly. thoroughly elaborated healthcare measures enhance process be implemented into practice.

Language: Английский

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ANALYSIS OF THE SPECTRUM OF RESPIRATORY TRACT MICROFLORA IN PATIENTS WITH RESPIRATORY INFECTIONS FOR 2018-2023

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Journal Year: 2024, Volume and Issue: 24(4), P. 58 - 62

Published: Dec. 26, 2024

The COVID-19 pandemic has undoubtedly affected the spectrum of microorganisms, their resistance to antibiotics, emergence multidrug-resistant strains and increased consumption antibiotics by patients with in hospitals. data from world national literature on dynamics respiratory microflora context are currently incomplete contradictory. purpose study is analyse patients' tract for period 2018-2023. A retrospective analysis results microbiological monitoring microorganisms isolated biomaterials 2770 acute diseases 2018 2023 was conducted based obtained Poltava Regional Clinical Infectious Diseases Hospital Council. It found out that before 2018-2019 pandemic, coccal represented S. aureus, pneumoniae, haemolyticus, Agalacticae, predominantly recorded among pathogens. During 2020-2023, pathogens changed characterised an increase proportion C. albicans, Enterococcus spp., K. pneumoniae. When comparing 2020-2021 period, which irrational use antimicrobials, 2022-2023, when began be used more moderately, differences were also identified microbial landscape. In compared 2020-2021, there again a trend towards microflora, particular pyogenes spp. Acinetobacter, decrease albicans haemolyticus. Thus, prior (S. agalacticae) dominated change fungal hospital-acquired (C. pneumoniae). analyzing it revealed tendency Acinetobacter)

Language: Английский

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