Targeting ferroptosis: a new therapeutic opportunity for kidney diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 3, 2024

Ferroptosis is a form of non-apoptotic regulated cell death (RCD) that depends on iron and characterized by the accumulation lipid peroxides to lethal levels. involves multiple pathways including redox balance, regulation, mitochondrial function, amino acid, lipid, glycometabolism. Furthermore, various disease-related signaling also play role in regulating process oxidation. In recent years, with emergence concept ferroptosis in-depth study its mechanisms, closely associated biological conditions related kidney diseases, organ development, aging, immunity, cancer. This article reviews development ferroptosis, mechanisms (including GSH-GPX4, FSP1-CoQ1, DHODH-CoQ10, GCH1-BH4, MBOAT1/2 pathways), latest research progress involvement diseases. It summarizes diseases within frameworks metabolism, reactive oxygen biology, biology. The introduces key regulatory factors as well important concepts major open questions natural compounds. hoped future research, further breakthroughs can be made understanding regulation mechanism utilizing promote treatments for such acute injury(AKI), chronic disease (CKD), diabetic nephropathy(DN), renal carcinoma. paves way new approach prevent, treat clinical

Language: Английский

Fetal Hemoglobin as a Predictive Biomarker for Retinopathy of Prematurity: A Prospective Multicenter Cohort Study in Portugal

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 110 - 110

Published: Jan. 6, 2025

Background/Objectives: Retinopathy of prematurity (ROP) is a leading cause vision impairment in preterm infants, with its pathogenesis linked to oxygen exposure. Red blood cell (RBC) transfusions, commonly performed neonatal intensive care units (NICUs), reduce fetal hemoglobin (HbF) fraction, altering dynamics and potentially contributing ROP. We aimed investigate the relationship between RBC HbF percentage, ROP, evaluating as potential predictive biomarker. Methods: A multicenter, prospective study was conducted across eight Portuguese NICUs, involving infants born at <32 weeks gestational age (GA) or <1500 g. ROP staging followed International Classification (ICROP2). Clinical data were collected during hospitalization, fractions measured from samples first four life using standardized methods. Infants stratified by presence treatment requirement. Statistical analysis SPSS 28.0, p < 0.05. Results: Eighty-two (mean GA: 28.1 ± 2.1 weeks, birth weight: 1055.8 258.3 g) included. Among them, 29 (35.4%) presented 4 (4.9%) required treatment. had more transfusions lower percentages than those without (p 0.05). Lower associated 0.001). Kaplan–Meier survival curves showed higher risk reduced Conclusions: Low percentage may increase infants. could serve biomarker for prediction. Interventions preserving risk. Further studies are needed validate refine prevention strategies.

Language: Английский

Evaluation of the protective role of ellagic acid in retinal degeneration: an experimental model

Journal of The Arab Society for Medical Research, Journal Year: 2024, Volume and Issue: 19(2), P. 211 - 220

Published: July 1, 2024

Background/aim Ellagic acid (EA) is widely recognized as a natural compound with pharmacological potency polyphenolic molecule, possessing antioxidant, anti-inflammatory, antimutagenic, and antiproliferative characteristics. The present study aims to evaluate the potential neuroprotective effect of EA in retinal degeneration induced experimentally rabbits. Material methods A total 27 male white New Zealand rabbits, an average weight ranging from 1.5 2 kg, were divided into three groups (nine each). Group I served control group, while group II III, macular (MD) induction that received single intravitreal injection sodium iodate (SI). Following injection, III was given 50 mg/kg powder for 21 days, starting immediately after MD induction. Ophthalmic examinations retinas conducted on days 7, 14, using fundus camera, followed by electroretinogram (ERG) recording Apoptotic caspase-3 caspase-7 activities retina tissues also measured postdecapitation. Results results showed significant decrease ( P ≤0.05) ‘a- b-waves’ following SI comparing group. pattern internucleosomal fragmentation, indicating apoptosis, time-dependent. increased relative activity. However, rabbits treated exhibited noticeable improvements these outcomes MD-induced Conclusions administration demonstrated notable impact improving retina’s function, decreased apoptosis levels model

Language: Английский