Homogeneous Polyporus polysaccharide exerts anti-bladder cancer effects via autophagy induction

Pharmaceutical Biology, Journal Year: 2024, Volume and Issue: 62(1), P. 214 - 221

Published: Feb. 14, 2024

Context Polyporus polysaccharide (PPS), the leading bioactive ingredient extracted from umbellatus (Pers.) Fr. (Polyporaceae), has been demonstrated to exert anti-bladder cancer and immunomodulatory functions in macrophages.

Language: Английский

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Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II)

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 8896 - 8896

Published: Aug. 10, 2022

Triterpenic acids are a widespread class of phytocompounds which have been found to possess valuable therapeutic properties such as anticancer, anti-inflammatory, hepatoprotective, cardioprotective, antidiabetic, neuroprotective, lipolytic, antiviral, and antiparasitic effects. They subclass triterpenes bearing characteristic lipophilic structure that imprints unfavorable in vivo subsequently limit their applications. The early investigation the mechanism action (MOA) drug candidate can provide information regarding possible side effects interactions may occur after administration. current paper aimed summarize most recent (last 5 years) studies MOA betulinic acid, boswellic glycyrrhetinic madecassic moronic pomolic acid order scientists with updated accessible material on topic could contribute development future studies; stands sequel our previously published triterpenic value. literature has highlighted role several signaling pathways including PI3/AKT/mTOR, TNF-alpha/NF-kappa B, JNK-p38, HIF-α/AMPK, Grb2/Sos/Ras/MAPK, trigger various biological activities.

Language: Английский

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Dioscin promotes autophagy by regulating the AMPK-mTOR pathway in ulcerative colitis

Immunopharmacology and Immunotoxicology, Journal Year: 2022, Volume and Issue: 44(2), P. 238 - 246

Published: Feb. 17, 2022

Dioscin is reported to alleviate the dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in mice. Autophagy plays an anti-inflammatory role UC. We herein aimed explore biological functions of dioscin autophagy UC.To effects on UC progression, a DSS-induced mouse model was established. Body weight, disease activity index and macroscopic damage scores were recorded for seven days. Hematoxylin & Eosin (HE) staining used stain colon sections BX53 microscope prepared observe pathological changes. The activities glutathione, superoxidative dismutase, malondialdehyde determined by commercially available kits. Western blotting performed measure protein levels p-AMPK/AMPK, p-mTOR/mTOR autophagy-related genes.The oxidative stress mice ameliorated after treatment. promoted phosphorylation AMPK inhibit mTOR activation facilitated UC.Dioscin promotes promoting colitis.

Language: Английский

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Ziziphus mauritiana Leaf Extract Induces ROS-dependent Apoptosis by Downregulation of CD81 in MDA- MB 231 Triple Negative Breast Cancer Cells

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Background. Breast cancer (BC) is the most prevalent among women, with triple-negative breast (TNBC) representing a particularly aggressive subtype. Current treatments often have limited efficacy and significant toxicity, highlighting need for alternative therapeutic strategies. Ziziphus mauritiana (ZM) leaf extract contains triterpenoids which been proven to be used as anticancer agents, but not studied in TNBC cells. Aim. To examine triterpenoid content ZM, especially BA OA, ZM cytotoxicity, intracellular ROS levels, amount of apoptosis, CD81 expression on MDA-MB 231 cells after being given ZM. Material Methods. The was prepared using sequential extraction method. presence confirmed via HPLC LC-MS analysis. cytotoxicity assessed CCK-8 assay, while flow cytometry employed analyze levels. Apoptosis quantified an Annexin V-FITC/PI detection kit. Results. Based HPLC, 28.3 µg/ml, OA 13.4 µg/ml. significantly reduced cell viability by 28.28% at 400 µg/ml 48 hours. Flow revealed notable downregulation (p < 0.0001) increase levels 0.0001). Furthermore, induced early late apoptosis treated cells, increases 2.34-fold 2.66-fold, respectively. Conclusion. exhibits potent cytotoxic effects against through ROS-dependent downregulation, suggesting its potential novel agent treatment.

Language: Английский

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Anticancer Properties of Dillenia suffruticosa (Griffith Ex. Hook. F. & Thomsom) Martelli

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100736 - 100736

Published: Jan. 1, 2025

Language: Английский

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Enhanced ZBTB10 expression induced by betulinic acid inhibits gastric cancer progression by inactivating the ARRDC3/ITGB4/PI3K/AKT pathway

Cellular Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

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Review: performance of jujube and its extracts in cancer: therapeutic, toxicity-reducing and potentiating effects

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 29, 2025

Cancer is one of the most serious public health challenges in world. The number new and fatal patients with cancer continues to increase every year, which poses a threat human health. Although there are effective treatments such as radiotherapy chemotherapy for cancers, they often accompanied by side effects. With development pharmaceutical industry, gradual desire develop low-toxicity anticancer drugs from traditional Chinese herbs. Due its “homology medicine food,” jujube herbs that extensively used China. In addition, has received much attention around world excellent pharmacological effects food value. This article reviews fruit, food, drug, jujube, have been shown current studies, analyzes therapeutic mechanism, active ingredients, extraction isolation methods, well synergistic attenuation performance cancer. will further promote progress natural medicine’s anti-cancer effect.

Language: Английский

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COTI-2 suppresses the malignancy of bladder cancer by inducing apoptosis via the AMPK-mTOR signaling pathway.

PubMed, Journal Year: 2025, Volume and Issue: 28(3), P. 240 - 246

Published: Jan. 1, 2025

COTI-2, an innovative oral homocysteine, has shown promising antitumor results on multiple types of cancer. However, its effects in treating bladder cancer (BCa) and the underlying molecular mechanisms have not been elucidated. The present study aimed to explore COTI-2 BCa potential mechanisms. cell lines, including 5637 T24 were treated with at concentrations 0.5 1 μM, respectively. Cell Counting Kit (CCK)-8 assay, colony formation apoptosis transwell migration invasion assay conducted evaluate cells. Western blotting, H&E, immunohistochemical staining, immunofluorescence analysis performed investigate Moreover, a xenograft model nude mice using cells was generated determine activities vivo. highly inhibited proliferation cells, induced their apoptosis. it efficiently suppressed Additionally, subcutaneous showed that treatment tumor growth by inducing We also found promoted presumably through activating AMPK/mTOR pathway. Our data suggest effectively reduces malignancy BCa, probably via signaling These highlight as therapeutic agent for BCa.

Language: Английский

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Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis

Molecules, Journal Year: 2022, Volume and Issue: 28(1), P. 67 - 67

Published: Dec. 21, 2022

The pursual of novel anticancer molecules from natural sources has gained worthwhile appreciation, and a significant fraction conceptual knowledge revolutionized our understanding about heterogeneous nature cancer. Betulinic acid fascinated interdisciplinary researchers due to its tremendous pharmacological properties. Ground-breaking discoveries have unraveled previously unprecedented empirical proof-of-concept momentous chemopreventive role betulinic against carcinogenesis metastasis. Deregulation cell signaling pathways been reported play linchpin in cancer progression colonization metastatically competent cells the distant organs for development secondary tumors. Importantly, demonstrated unique properties mechanistically modulate oncogenic transduction cascades. In this mini-review, we attempted provide sophisticated compendium regulatory chemoprevention. We partitioned multi-component review into different sections which summarized landmark research-works highlighted mediated regulation JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR ubiquitination inhibition parallel, cascades non-coding RNAs will be critically analyzed culture animal model studies. Better comprehension pharmaceutical features mapping existing gaps valuable translatability preclinical studies rationally designed clinical trials.

Language: Английский

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Isoprenoid flavonoids isolated from Sophora davidii and their activities induces apoptosis and autophagy in HT29 cells

Fitoterapia, Journal Year: 2024, Volume and Issue: 175, P. 105945 - 105945

Published: April 2, 2024

Language: Английский

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