Targeting the PD-1/PD-L1 Signaling Pathway for Cancer Therapy: Focus on Biomarkers

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1235 - 1235

Published: Jan. 31, 2025

The PD1/PD-L1 axis plays an important immunosuppressive role during the T-cell-mediated immune response, which is essential for physiological homeostasis of system. biology immunological microenvironment extremely complex and crucial development treatment strategies immunotherapy. Characterization immunological, genomic or transcriptomic landscape cancer patients could allow discrimination between responders non-responders to anti-PD-1/PD-L1 therapy. Immune checkpoint inhibitor (ICI) therapy has shown remarkable efficacy in a variety malignancies landmark trials fundamentally changed Current research focuses on maximize patient selection therapy, clarify mechanisms resistance, improve existing biomarkers, including PD-L1 expression tumor mutational burden (TMB), discover new biomarkers. In this review, we focus function PD-1/PD-L1 signaling pathway discuss genomic, epigenetic receiving Finally, provide overview clinical testing antibodies against PD-1/PD-L1.

Language: Английский

---

LINC01271 promotes fracture healing via regulating miR-19a-3p/PIK3CA axis

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 10, 2025

Osteoporosis increases the risk of fragility fractures, impacting patients' lives. This study aimed to investigate whether LINC01271 was involved in process fractures and healing, providing a new perspective for its diagnosis treatment. included 94 healthy individuals, 82 patients with osteoporosis, 85 as subjects. RT-qPCR used measure levels LINC01271, miR-19a-3p, PIK3CA, osteogenic differentiation markers osteoblasts subjects' serum. Luciferase reporter assays, RIP experiments, RNA pull-down assays were utilized verify target relationships between well miR-19a-3p PIK3CA. Cell proliferation apoptosis assessed using CCK-8 flow cytometry. Compared control group, serum significantly reduced osteoporosis fractures. Furthermore, increased time-dependent fracture healing. In vitro studies indicated that boosted osteoblast proliferation, inhibited apoptosis, augmented differences, whereas inhibition reverses their effects. PIK3CA identified targets overexpression could antagonize effect promoting The results may play key role function healing through interaction regulation

Language: Английский

---

The pathogenesis mechanism and potential clinical value of lncRNA in gliomas

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 5, 2024

Abstract Glioma is the most common malignant tumor in central nervous system, and its unique pathogenesis often leads to poor treatment outcomes prognosis. In 2021, World Health Organization (WHO) divided gliomas into five categories based on their histological characteristics molecular changes. Non-coding RNA a type of that does not encode proteins but can exert biological functions at level, long non-coding (lncRNA) with length exceeding 200 nt. It controlled by various transcription factors plays an indispensable role regulatory processes cells. Numerous studies have confirmed dysregulation lncRNA critical pathogenesis, progression, malignancy gliomas. Therefore, this article reviews proliferation, apoptosis, invasion, migration, angiogenesis, immune regulation, glycolysis, stemness, drug resistance changes caused gliomas, summarizes potential clinical significance

Language: Английский

---

Gene Expression Profile Identifies LncRNA AL355974.3 As a Potential Glioma Biomarker

Current Medical Science, Journal Year: 2024, Volume and Issue: 44(5), P. 1047 - 1057

Published: Aug. 15, 2024

Language: Английский

---