miR‐185 affected the EMT, cell viability, and proliferation via DNMT1/MEG3 pathway in TGF‐β1‐induced renal fibrosis DOI
Rong Xue, Yingping Li, Xiaoli Li

et al.

Cell Biology International, Journal Year: 2018, Volume and Issue: 43(10), P. 1152 - 1162

Published: Aug. 10, 2018

Abstract Kidney fibrosis is usually the final manifestation of a wide variety renal diseases. Recent years, research reported that long non‐coding RNAs (lncRNAs) played important roles in human However, role and underlying mechanisms lncRNAs kidney were complicated largely unclear. In our study, we constructed cell model HK2 cells using transforming growth factor β1 (TGF‐β1) found lncRNA maternally expressed gene 3 (MEG3) was downregulated TGF‐β1‐induced fibrosis. We then overexpressed MEG3 inhibited promotion epithelial–mesenchymal transition, viability, proliferation. Furthermore, demonstrated DNA methyltransferases 1 (DNMT1) regulated expression by altering CpGs methylation level promoter addition, further revealed miR‐185 could regulate DNMT1 thus, modulate Ultimately, study illustrated modulation miR‐185/ DNMT1/ pathway exerted summary, finding displayed novel regulatory mechanism for fibrosis, which provided new potential therapeutic target

Language: Английский

Curcumin suppresses tumor growth of gemcitabine-resistant non-small cell lung cancer by regulating lncRNA-MEG3 and PTEN signaling DOI
Likun Gao, Tingting Shao, Wenkui Zheng

et al.

Clinical & Translational Oncology, Journal Year: 2021, Volume and Issue: 23(7), P. 1386 - 1393

Published: Feb. 10, 2021

Language: Английский

Citations

38
Long Non-Coding RNA MEG3 in Metal Carcinogenesis DOI Creative Commons

Zhuo Zhang,

Sophia Shi,

Jingxia Li

et al.

Toxics, Journal Year: 2023, Volume and Issue: 11(2), P. 157 - 157

Published: Feb. 7, 2023

Most transcripts from human genomes are non-coding RNAs (ncRNAs) that not translated into proteins. ncRNAs divided long (lncRNAs) and small (sncRNAs). LncRNAs regulate their target genes both transcriptionally post-transcriptionally through interactions with proteins, RNAs, DNAs. Maternally expressed gene 3 (MEG3), a lncRNA, functions as tumor suppressor. MEG3 regulates cell proliferation, cycle, apoptosis, hypoxia, autophagy, many other processes involved in development. is downregulated various cancer lines primary cancers. Heavy metals, such hexavalent chromium (Cr(VI)), arsenic, nickel, cadmium, confirmed carcinogens. The exposure of cells to these metals causes variety Among them, lung the one can be induced by all metals. In vitro studies have demonstrated chronic normal bronchial epithelial (BEAS-2B) cause malignant transformation. Metal-transformed capability an increase resistance elevated migration invasion, properties stem-like cells. Studies revealed MEG Cr(VI)-transformed cells, nickel-transformed cadmium (Cd)-transformed forced expression reduces invasion downregulation neuronal precursor developmentally protein 9 (NEDD9). suppresses transformation overexpression decreases Bcl-xL, causing reduced apoptosis Cd-transformed This paper reviews current knowledge lncRNA metal carcinogenesis.

Language: Английский

Citations

15
Targeting crosstalk of signaling pathways in cancer stem cells: a promising approach for development of novel anti-cancer therapeutics DOI
Subhasmita Bhal, Chanakya Nath Kundu

Medical Oncology, Journal Year: 2023, Volume and Issue: 40(2)

Published: Jan. 20, 2023

Language: Английский

Citations

14
Identification of long non-coding RNA signatures in triple-negative breast cancer DOI Creative Commons
Tian Tian,

Zhouqing Gong,

Meng Wang

et al.

Cancer Cell International, Journal Year: 2018, Volume and Issue: 18(1)

Published: July 17, 2018

Triple-negative breast cancer (TNBC) is a particular subtype with poor prognosis due to its aggressive biological behavior and lack of targets for therapy. This study aimed explore the expression profile potential function lncRNAs in TNBC through bioinformatic methods.Two microarrays were obtained from Gene Expression Omnibus database. Differentially expressed mRNAs screened out expressions top overlapping validated using data The Cancer Genome Atlas co-expression analysis was conducted R software functional enrichment performed by Metascape. Kaplan-Meier Plotter used survival analysis.A total 1034 dysregulated found two microarrays, there 8 overlapped lncRNAs. Among them, 537 significantly correlated 451 protein-coding genes (PCGs). co-expressed PCGs mainly enriched terms including cell division, cycle, protein/DNA binding, involved pathways other such as PI3K-Akt, MAPK, ErbB p53 signaling pathways. Hub-genes network identified, 7 them associated relapse-free (MAGI2-AS3: HR = 0.51; GGTA1P: 0.54; NAP1L2: 0.59; CRABP2: 0.41; SYNPO2: 0.50; MKI67: 2.23; COL4A6: 1.91; all P < 0.05).Numerous TNBC, many are possibly biology. Several these prognosis, which can be promising biomarkers.

Language: Английский

Citations

45
miR‐185 affected the EMT, cell viability, and proliferation via DNMT1/MEG3 pathway in TGF‐β1‐induced renal fibrosis DOI
Rong Xue, Yingping Li, Xiaoli Li

et al.

Cell Biology International, Journal Year: 2018, Volume and Issue: 43(10), P. 1152 - 1162

Published: Aug. 10, 2018

Abstract Kidney fibrosis is usually the final manifestation of a wide variety renal diseases. Recent years, research reported that long non‐coding RNAs (lncRNAs) played important roles in human However, role and underlying mechanisms lncRNAs kidney were complicated largely unclear. In our study, we constructed cell model HK2 cells using transforming growth factor β1 (TGF‐β1) found lncRNA maternally expressed gene 3 (MEG3) was downregulated TGF‐β1‐induced fibrosis. We then overexpressed MEG3 inhibited promotion epithelial–mesenchymal transition, viability, proliferation. Furthermore, demonstrated DNA methyltransferases 1 (DNMT1) regulated expression by altering CpGs methylation level promoter addition, further revealed miR‐185 could regulate DNMT1 thus, modulate Ultimately, study illustrated modulation miR‐185/ DNMT1/ pathway exerted summary, finding displayed novel regulatory mechanism for fibrosis, which provided new potential therapeutic target

Language: Английский

Citations

41