Organometallic complexes of neodymium: an overview of synthetic methodologies based on coordinating elements DOI

Adeena Asif,

Rana Yasir Nadeem, Muhammad Adnan Iqbal

et al.

Reviews in Inorganic Chemistry, Journal Year: 2021, Volume and Issue: 41(2), P. 77 - 130

Published: Jan. 21, 2021

Abstract Organometallic complexes of neodymium have unique coordinating ability to form both micro and macromolecules as well metal-based polymers. These been reported in different fields play a tremendous role luminescence, catalytic, biological magnetic applications. So, the current study will comprise all possible routes for synthesis organometallic neodymium. Neodymium synthesized single, double, triple tetra linkages with H, C, N, O S, B, X. The detailed synthetic classified into four categories but brief, forms by reacting metal chloride, nitrate or oxide (hydrated dehydrated) precursor along appropriate ligand. Most applied solvents were Toluene THF. required range temperature based on nature linkages. authors surveyed research work published through 2011–2020 provide comprehensive overview understand

Language: Английский

Synthesis of 3-selanyl-isoflavones from 2-hydroxyphenyl enaminones using trichloroisocyanuric acid (TCCA): a sustainable approach DOI

Carlos V. Doerner,

José S. S. Neto,

Climei R. Cabreira

et al.

New Journal of Chemistry, Journal Year: 2023, Volume and Issue: 47(12), P. 5598 - 5602

Published: Jan. 1, 2023

We hereby present an original and sustainable synthetic methodology for the synthesis of 3-selanyl-isoflavones from 2-hydroxyphenyl enaminones diorganoyl diselenides.

Language: Английский

Citations

16
Synthesis, Characterization, and Evaluation of Antifungal Activity of 1-Butyl-3-hexyl-1H-imidazol-2(3H)-selenone by Surface-Enhanced Raman Spectroscopy DOI Creative Commons
Noor ul Huda, Muhammad Wasim, Haq Nawaz

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(39), P. 36460 - 36470

Published: Sept. 21, 2023

In the present research work, a selenium N-heterocyclic carbene (Se-NHC) complex/adduct was synthesized and characterized by using different analytical methods including FT-IR, 1HNMR, 13CNMR. The antifungal activity of Se-NHC complex against Aspergillus flavus (A. flavus) fungus investigated with disc diffusion assay. Moreover, biochemical changes occurring in this due to exposure concentrations in-house compound are surface-enhanced Raman spectroscopy (SERS) illustrated form SERS spectral peaks. analysis yields valuable information about probable mechanisms responsible for effects complex. As demonstrated spectra, caused denaturation conformational proteins as well decomposition fungal cell membrane. spectra were analyzed two chemometric tools such principal component (PCA) partial least-squares discriminant (PLS-DA). samples' differentiated PCA, while various groups discriminated ultrahigh sensitivity (98%), high specificity (99.7%), accuracy (100%), area under receiver operating characteristic curve (87%) PLS-DA.

Language: Английский

Citations

15
Synthesis, Characterization, and DFT Studies of NHC-Derived Amide-Functionalized Organoselenium Compounds DOI Creative Commons

Ismat Nawaz,

Muhammad Naeem Khan, Syed Tasadaque Ali Shah

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(10), P. 10579 - 10593

Published: March 3, 2025

The NHC-Se scaffold has emerged as an intriguing target, opening new avenues for discovering compounds that could significantly improve public health. Recently, extensive efforts have been made to synthesize NHC-Se-based organic various biomedical applications. Herein, we disclose a straightforward method access series of N-heterocyclic carbene (NHC)-derived organoselenium molecules functionalized with amide moiety. parent adduct pendent ester moiety is sufficiently activated facilitate base- and additive-free ester-to-amide bond transformation. Furthermore, the use PEG 3550, biocompatible solvent, enhances reaction efficiency simplifies workup. This approach employs broad spectrum aliphatic amines good functional group tolerance, offering versatile ecofriendly extending chemical space around compounds. Additionally, density theory (DFT) calculations provide insights into electronic properties, stability, reactivity profiles synthesized compounds, suggesting their promising potential applications in fields.

Language: Английский

Citations

0
Organotellurium compounds: an overview of synthetic methodologies DOI
Muhammad Irfan, Rabia Rehman, Mohd. R. Razali

et al.

Reviews in Inorganic Chemistry, Journal Year: 2020, Volume and Issue: 40(4), P. 193 - 232

Published: Aug. 7, 2020

Abstract In wake of emerging applications organotellurium compounds in biological and material science avenues, the current review describes their key synthetic methodologies while focusing synthesis through five ligand-to-metal linkages including carbon; carbon-oxygen; carbon-nitrogen; carbon-metal; carbon-sulfur to tellurium. all these whether tellurium links with ligands a complicated or simple pathways, it is often governed electrophilic substitution reactions. The present study encompasses major routes so as acquire comprehensive understanding compounds.

Language: Английский

Citations

25
In vitro and in silico anticancer potential of binuclear silver (I) N-heterocyclic carbene (NHCs) complexes: Investigation of interaction with surfactants DOI
Rizwan Ashraf, Sumia Akram, Mohamed El‐Naggar

et al.

Inorganica Chimica Acta, Journal Year: 2024, Volume and Issue: 571, P. 122181 - 122181

Published: June 6, 2024

Language: Английский

Citations

3
Selenium-N-heterocyclic carbene (Se-NHC) complexes with higher aromaticity inhibit microbes: synthesis, structure, and biological potential DOI

Amna Kamal,

Muhammad Adnan Iqbal, Haq Nawaz Bhatti

et al.

Journal of Coordination Chemistry, Journal Year: 2022, Volume and Issue: 75(11-14), P. 1915 - 1928

Published: July 18, 2022

The synthesis of five selenium complexes bearing imidazole-based N-heterocyclic carbene ligands (Se-NHC) are reported. adducts were characterized by elemental and spectroscopic analysis (FTIR, 1H 13C NMR). Single-crystal XRD confirmed the structures two Se-NHC adducts, VIII XI. Zone inhibition (ZOI) values evaluated towards bacterial (Bacillus thuringiensis Escherichia coli) one fungal strain (Candida albicans). most active tested compound was XI with value 24.1 ± 0.1 mm against E. coli, it showed higher activity than Tetracycline (reference drug). Similarly, exhibited good potential C. albicans (26.5 0.2 mm). hemolytic assay demonstrated that compounds (VIII-XII) non-toxic to healthy human blood; however, thrombolysis indicated VIII-XII could be used as thrombolytic agents. It is concluded having more aromatic rings at terminal nitrogens imidazole effective other compounds. have efficacy strains strain.

Language: Английский

Citations

14
Bioactivity and DNA/BSA Interactions of Selenium N‐Heterocyclic Carbene Adducts DOI
Rizwan Ashraf, Muhammad Adnan Iqbal, Haq Nawaz Bhatti

et al.

ChemistrySelect, Journal Year: 2020, Volume and Issue: 5(35), P. 10970 - 10981

Published: Sept. 16, 2020

Abstract In wake of promising biomedical applications organo‐selenium compounds, the present work was planned to synthesize selenium adducts ( 1 s ‐ ‐4 ) and their respective azolium ligands a – 4 ), which were subsequently authenticated by various analytical spectroscopic techniques like microanalysis, UV‐Visible, FT‐IR, H & 13 C NMR Electrospray Ionisation‐Mass Spectrometry (ESI‐MS). Moreover, synthesized compounds tested for biological potential antioxidant, antimicrobial, hemolytic, DNA Bovin Serum Albumin (BSA) interactions, stability lipophilicity using in‐vitro models. All found stable in solution form studied period 12–68 hours showed good lipophilic values range logP 0.66–0.85. context activities, better antimicrobial (ranging 17.4±0.5–25.3±0.8 mm against S. aureus 18.6±0.7–24.1±0.9 E.coli at concentration 0.3 mg/mL both strains) antioxidant (IC 50 ranging 40.0–62.0 μg/mL DPPH solutions) compared ligands. The interaction study BSA prominent binding affinity.

Language: Английский

Citations

16
Synthesis in combination with Biological and Computational evaluations of selenium-N-Heterocyclic Carbene compounds DOI
Nida Iqbal,

Munazzah Yaqoob,

Mehwish Javed

et al.

Computational and Theoretical Chemistry, Journal Year: 2020, Volume and Issue: 1197, P. 113135 - 113135

Published: Dec. 28, 2020

Language: Английский

Citations

14
N-heterocyclic carbene based Bi-nuclear organoselenium compounds impart a mild biocidal potential compared to their ligands: Synthesis, characterization, computational studies DOI
Ahmad Hassan, Muhammad Adnan Iqbal, Haq Nawaz Bhatti

et al.

Computational Biology and Chemistry, Journal Year: 2023, Volume and Issue: 107, P. 107963 - 107963

Published: Sept. 26, 2023

Language: Английский

Citations

4
Synthesis of Water-Soluble Menthol Derivatives Using Response Surface Methodology DOI Creative Commons
Shafaq Nisar, Muhammad Asif Hanif, Umer Rashid

et al.

Indonesian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 24(6), P. 1701 - 1701

Published: Dec. 1, 2024

In this study, menthol was glycosylated with starch in the presence of α-amylase to produce menthyl maltoside (MenM) as primary product. Optimization experimental parameters, including menthol-starch ratio, enzyme concentration, temperature, and time, performed using response surface methodology (RSM). The RSM-generated model displayed adequate accuracy reasonable predictability for MenM yield under specified conditions. Under optimized reaction conditions menthol-to-starch ratio 1:3 (50 °C, 18 h) concentration 50 U, highest (23.7%) obtained. Fourier transform infrared nuclear magnetic resonance spectroscopies were employed analyze synthesized derivative MenM. Compared standard menthol, derivatives various biological activities, antioxidant, antibacterial, antifungal, insecticidal properties. results study demonstrate effectiveness RSM-optimized synthesis from glycosylation starch. This showed that is highly soluble water can be easily stored owing its non-volatile nature.

Language: Английский

Citations

1