Advances in Clinical Medicine, Journal Year: 2022, Volume and Issue: 12(11), P. 10026 - 10033
Published: Jan. 1, 2022
Language: Английский
Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(13)
Published: June 30, 2024
Biological sex is an important modifier of physiology and influences pathobiology in many diseases. While heart disease the number one cause death worldwide both men women, differences exist at organ cellular scales, affecting clinical presentation, diagnosis, treatment. In this Review, we highlight baseline cardiac structure, function, signaling discuss contribution hormones chromosomes to these characteristics. The a remarkably plastic rapidly responds physiological pathological cues by modifying form function. nature extent remodeling response stimuli are often dependent on biological sex. We organ- molecular-level adaptive from pressure volume overload, ischemia, genetic disease. Finally, offer perspective key future directions for research into differences.
Language: Английский
Citations
18
Aging and Disease, Journal Year: 2023, Volume and Issue: 14(3), P. 670 - 670
Published: Jan. 1, 2023
The biomechanical properties of extracellular matrices (ECM) and their consequences for cellular homeostasis have recently emerged as a driver aging. Here we review the age-dependent deterioration ECM in context our current understanding aging processes. We discuss reciprocal interactions longevity interventions with remodeling. And relevance dynamics captured by matrisome matreotypes associated health, disease, longevity. Furthermore, highlight that many established compounds promote homeostasis. A large body evidence to qualify hallmark is emerging, data invertebrates promising. However, direct experimental proof activating sufficient slow mammals lacking. conclude further research required anticipate conceptual framework biomechanics will provide new strategies health during
Language: Английский
Citations
40
GeroScience, Journal Year: 2025, Volume and Issue: unknown
Published: March 2, 2025
Language: Английский
Citations
1
Cardiovascular Research, Journal Year: 2024, Volume and Issue: unknown
Published: June 26, 2024
Abstract Cardiac ageing is an intricate and multifaceted process with considerable impact on public health, especially given the global demographic shift towards aged populations. This review discusses structural, cellular, functional changes associated cardiac heart failure preserved ejection fraction (HFpEF). Key molecular mediators are considered within framework of established hallmarks ageing, particular attention to promising therapeutic candidates. We further delineate differential impacts structure function in men women, addressing hormonal chromosomal influences. The protective mitigating effects exercise HFpEF discussed, as inspiration for identification pathways that mitigate biological ageing. also emphasize how much remains be learned importance these efforts enhancing health populations worldwide.
Language: Английский
Citations
7
Matrix Biology, Journal Year: 2024, Volume and Issue: 134, P. 1 - 22
Published: Aug. 29, 2024
Language: Английский
Citations
7
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(10), P. 5803 - 5803
Published: May 22, 2022
Propionic acid is a cell nutrient but also stimulus for cellular signaling. Free fatty receptor (FFAR)-3, known as GPR41, Gi/o protein-coupled (GPCR) that mediates some of the propionate's actions in cells, such inflammation, fibrosis, and increased firing/norepinephrine release from peripheral sympathetic neurons. The regulator G-protein Signaling (RGS)-4 inactivates (terminates) both Gi/o- Gq-protein signaling and, heart, protects against atrial fibrillation via calcium attenuation. RGS4 activity stimulated by β-adrenergic receptors (ARs) protein kinase A (PKA)-dependent phosphorylation. Herein, we examined whether modulates cardiac FFAR3 signaling/function. We report essential dampening H9c2 cardiomyocytes, since siRNA-mediated depletion significantly enhanced propionate-dependent cAMP lowering, activation, p38 MAPK pro-inflammatory interleukin (IL)-1β IL-6 production, pro-fibrotic transforming growth factor (TGF)-β synthesis. Additionally, catecholamine pretreatment blocked propionic acid/FFAR3 PKA-dependent activation cardiomyocytes. Finally, opposes FFAR3-dependent norepinephrine sympathetic-like neurons (differentiated Neuro-2a cells) co-cultured with thereby preserving functional βAR number In conclusion, appears propionate/FFAR3 attenuation cardiomyocytes neurons, leading to cardioprotection inflammation/adverse remodeling sympatholysis, respectively.
Language: Английский
Citations
26
Clinical Research in Cardiology, Journal Year: 2024, Volume and Issue: unknown
Published: March 11, 2024
Abstract Background Aging as a major non-modifiable cardiac risk factor challenges future cardiovascular medicine and economic demands, which requires further assessments addressing physiological age-associated changes. Objectives Using magnetic resonance (CMR), this study aims to characterize sex-specific ventricular adaptations during healthy aging. Methods The population included volunteers who underwent CMR at 1.5 or 3 Tesla scanners applying cine-imaging with short-axis coverage of the left (LV) right (RV) ventricle. cohort was divided by sex (female male) age (subgroups in years): 1 (19–29), 2 (30–39), (40–49), 4 (≥50). Cardiac were quantitatively assessed indices. Results After exclusion missing poor-quality datasets diagnosed disease, 140 203 part final analysis. Women generally had smaller dimensions LV mass, but higher biventricular systolic function. There significant decrease well increase mass-to-volume ratio (LV-MVR, concentricity) both sexes (LV-MVR g/ml: group vs. 4: females 0.50 0.57, p =0.016, males 0.56 0.67, =0.024). stroke volume index decreased significantly sexes, stronger for men than women (in ml/m : 51.76 41.94, <0.001, 55.31 40.78, <0.001). Ventricular proportions (RV-to-LV-volume ratio) constant between groups sexes. Conclusions In aging associated an concentricity decline dimensions. Furthermore, relevant age-related differences performance observed. Graphical ↓, decrease; ↑, increase; ±, maintaining. Abbreviations: CMR, resonance; EDV, end-diastolic volume; EF, ejection fraction; LV, ventricle; MVR, ratio; RV, SVI, index; T, Tesla; VR, ratio.
Language: Английский
Citations
4
Journal of Molecular and Cellular Cardiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Nature Cardiovascular Research, Journal Year: 2023, Volume and Issue: 2(4), P. 340 - 350
Published: April 3, 2023
Language: Английский
Citations
10
Cells, Journal Year: 2023, Volume and Issue: 12(16), P. 2102 - 2102
Published: Aug. 19, 2023
Fabry disease (FD) is a lysosomal disorder caused by α-galactosidase A deficiency, resulting in the accumulation of globotriaosylceramide (Gb-3) and its metabolite globotriaosylsphingosine (Lyso-Gb-3). Cardiovascular complications hypertrophic cardiomyopathy (HCM) are most frequent manifestations FD. While an echocardiogram cardiac MRI clinical tools to assess involvement, pattern variations fibrosis make it crucial identify biomarkers predict early outcomes. This study aims investigate potential associated with HCM FD: transforming growth factor-β1 (TGF-β1), TGF-β active form (a-TGF-β), vascular endothelial factor (VEGF-A), fibroblast (FGF2) 45 patients FD, categorized into cohorts based on severity. TGF-β1, a-TGF-β, FGF2, VEGF-A were elevated association TGF-β1 was not gender-related, VEGF males FD HCM. Female abnormal electrocardiograms but without overt also have TGF-β1. Lyso-Gb3 correlated VEGF-A, a-TGF-β1. Elevation provides evidence chronic inflammatory state as cause myocardial patients; thus, marker detected even prior hypertrophy. may be prognostic indicators adverse cardiovascular events
Language: Английский
Citations
8