Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

Biomolecules, Journal Year: 2019, Volume and Issue: 9(11), P. 735 - 735

Published: Nov. 13, 2019

Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous ROS production normal cells is controlled by the appropriate regulation between silver lining of low high concentration mediated effects. Interestingly, also dynamically influences tumor microenvironment known to initiate cancer angiogenesis, metastasis, survival at different concentrations. At moderate concentration, activates cell signaling cascade involving mitogen-activated protein kinase/extracellular signal-regulated kinases 1/2 (MAPK/ERK1/2), p38, c-Jun N-terminal kinase (JNK), phosphoinositide-3-kinase/ B (PI3K/Akt), which turn activate nuclear factor kappa-light-chain-enhancer activated (NF-κB), matrix metalloproteinases (MMPs), vascular endothelial growth (VEGF). concentrations, can cause apoptosis. Hence, it critically depends upon levels, either augment tumorigenesis or lead The major issue targeting dual actions effectively with respect bias, needs be monitored carefully impede angiogenesis metastasis for serve as potential therapeutic targets exogenously/endogenously. Overall, additional research required comprehend an effective anti-tumor modality target treating malignancies.

Language: Английский

---

NK Cell Metabolism and Tumor Microenvironment

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Sept. 24, 2019

Natural Killer (NK) cells are characterized by their potential to kill tumor different means without previous sensitization and therefore, they have become a valuable tool in cancer immunotherapy. However, efficacy against solid tumors is still poor further studies required improve it. One of the major restrictions for NK cell activity immunosuppressive microenvironment (TME). There, other immune create appropriate conditions proliferation while, among others, preventing activation. Furthermore, metabolism impaired TME, presumably due nutrient oxygen deprivation, higher concentration tumor-derived metabolic end products, such as lactate. This restriction limits effector functions, it could represent target focus on cell-based therapies tumors. In this review, we discuss effect TME into its influence functions.

Language: Английский

---

Tumor-Infiltrating Natural Killer Cells

Cancer Discovery, Journal Year: 2020, Volume and Issue: 11(1), P. 34 - 44

Published: Dec. 4, 2020

Abstract Because of their potent antitumor activity and proinflammatory role, natural killer (NK) cells are at the forefront efforts to develop immuno-oncologic treatments. NK participate in immune responses tumors by killing target producing cytokines. However, immunosuppressive tumor microenvironment, become dysfunctional through exposure inhibitory molecules produced cancer cells, leading escape. We provide an overview what is known about infiltration surveillance mechanisms which dysfunctional. Significance: The functions tumor-infiltrating may be impaired. This review aims describe various alter NK-cell functions.

Language: Английский

---

Oncogenic pathways and the electron transport chain: a dangeROS liaison

British Journal of Cancer, Journal Year: 2019, Volume and Issue: 122(2), P. 168 - 181

Published: Dec. 10, 2019

Driver mutations in oncogenic pathways, rewiring of cellular metabolism and altered ROS homoeostasis are intimately connected hallmarks cancer. Electrons derived from different metabolic processes channelled into the mitochondrial electron transport chain (ETC) to fuel oxidative phosphorylation process. leaking ETC can prematurely react with oxygen, resulting generation reactive oxygen species (ROS). Several signalling pathways affected by ROS, which act as second messengers controlling cell proliferation survival. On other hand, hijack ETC, enhancing its ROS-producing capacity increasing flow or impinging on structure organisation ETC. In this review, we focus a source modulation generates vicious cycle that resets levels higher homoeostatic set point, sustaining cancer phenotype.

Language: Английский

---

Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications

Pharmacological Research, Journal Year: 2022, Volume and Issue: 177, P. 106114 - 106114

Published: Feb. 3, 2022

Language: Английский

---

CAR-T Cell Therapy for Breast Cancer: From Basic Research to Clinical Application

International Journal of Biological Sciences, Journal Year: 2022, Volume and Issue: 18(6), P. 2609 - 2626

Published: Jan. 1, 2022

Breast cancer rises as the most commonly diagnosed in 2020.Among women, breast ranks first both incidence rate and mortality.Treatment resistance developed from current clinical therapies limits efficacy of therapeutic outcomes, thus new treatment approaches are urgently needed.Chimeric antigen receptor (CAR) T cell therapy is a type immunotherapy adoptive transfer, which typically uses patients' own immune cells to combat cancer.CAR-T armed with specific antibodies recognize antigens self-tumor eliciting cytotoxic effects.In recent years, CAR-T has achieved remarkable successes treating hematologic malignancies; however, effects solid tumors not up expectations including cancer.This review aims discuss development preclinical studies ongoing trials.Specifically, we summarize tumor-associated cancer, trials, obstacles interfering therapy, potential strategies improve efficacy.Overall, hope our provides landscape view progress for ignites interest further research directions.

Language: Английский

---

The impact of lipid metabolism on breast cancer: a review about its role in tumorigenesis and immune escape

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: June 27, 2023

Abstract Background Breast cancer (BC) is the second most frequent type of in world and common among women, configuring a major challenge to global health. BC complex heterogeneous disease that can be subdivided into distinct tumor types based on expression molecular markers predicting patient outcomes response therapy. A growing number studies have tried expand known by investigating association altered lipid metabolism with immune escape, progression, metastasis. In this review, we describe metabolic peculiarities each subtype, understanding how influences its aggressiveness identifying whether these intrinsic vulnerabilities subtype play role therapeutic management may affect system cells microenvironment. Conclusion The evidence suggests so far when changes occur pathways, it availability structural lipids for membrane synthesis, degradation contribute energy homeostasis cell signaling functions. These findings will guide next steps path mechanisms underlying alterations are related disparities chemotherapeutic escape BC.

Language: Английский

---

Metabolic heterogeneity in cancer

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(1), P. 18 - 38

Published: Jan. 24, 2024

Language: Английский

---

Mechanisms and applications of radiation-induced oxidative stress in regulating cancer immunotherapy

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 4, 2023

Radiotherapy (RT) is an effective treatment option for cancer patients, which induces the production of reactive oxygen species (ROS) and causes oxidative stress (OS), leading to death tumor cells. OS not only apoptosis, autophagy ferroptosis, but also affects immune response. The combination RT immunotherapy has revolutionized management various cancers. In this process, caused by ROS plays a critical role. Specifically, RT-induced can promote release tumor-associated antigens (TAAs), regulate infiltration differentiation cells, manipulate expression checkpoints, change microenvironment (TME). review, we briefly summarize several ways in IR cell discuss interrelationship between antitumor immunity, with focus on interaction ferroptosis immunogenic death. We potential mechanisms regulates checkpoint expression, cells activity, differentiation. addition, conclude therapeutic opportunity improving radiotherapy regulating OS, may be beneficial clinical treatment.

Language: Английский

---

Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy

Journal of Cancer, Journal Year: 2021, Volume and Issue: 12(18), P. 5543 - 5561

Published: Jan. 1, 2021

Reactive oxygen species (ROS) play a dual role in the initiation, development, suppression, and treatment of cancer.Excess ROS can induce nuclear DNA, leading to cancer initiation.Not only that, but also inhibit T cells natural killer promote recruitment M2 polarization macrophages; consequently, escape immune surveillance defense.Furthermore, tumor invasion metastasis by triggering epithelial-mesenchymal transition cells.Interestingly, massive accumulation inhibits growth two ways: (1) blocking cell proliferation suppressing signaling pathway, cycle, biosynthesis nucleotides ATP (2) inducing death via activating endoplasmic reticulum stress-, mitochondrial-, P53-apoptotic pathways ferroptosis pathway.Unfortunately, adapt self-adaption system.This review highlighted bidirectional regulation cancer.The study further discussed application massively accumulated treatment.Of note, self-adaptive ability should be taken into consideration for prevention.

Language: Английский

---