Circadian rhythm regulates the function of immune cells and participates in the development of tumors

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: April 27, 2024

Abstract Circadian rhythms are present in almost all cells and play a crucial role regulating various biological processes. Maintaining stable circadian rhythm is essential for overall health. Disruption of this can alter the expression clock genes cancer-related genes, affect many metabolic pathways factors, thereby affecting function immune system contributing to occurrence progression tumors. This paper aims elucidate regulatory effects BMAL1, other on cells, reveal molecular mechanism rhythm’s involvement tumor its microenvironment regulation. A deeper understanding has potential provide new strategies treatment cancer immune-related diseases.

Language: Английский

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The Common Hallmarks of Aging, Circadian Rhythms and Cancer: Implications for Therapeutic Strategies

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.

Language: Английский

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Major roles of the circadian clock in cancer

Cancer Biology and Medicine, Journal Year: 2023, Volume and Issue: 20(1), P. 1 - 24

Published: Jan. 12, 2023

Circadian rhythms are natural that widely exist in all creatures, and regulate the processes physiological functions of various biochemical reactions. The circadian clock is critical for cancer occurrence progression. Its function regulated by metabolic activities, expression transcription genes. This review summarizes composition clock; biological basis its function; relationship with, mechanisms in, cancer; different cancers; effects anti-tumor treatment; potential therapeutic targets. Research this area expected to advance understanding locomotor output cycles kaput (CLOCK) brain muscle ARNT-like protein 1 (BMAL1) tumor diseases, contribute development new treatment strategies.

Language: Английский

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Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7579 - 7579

Published: April 20, 2023

Mental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle may largely explain this trend. Impaired rhythms are associated with mental disorders. The evening chronotype, which misalignment, risk factor for severe psychiatric symptoms metabolic comorbidities. Resynchronization of commonly improves symptoms. Furthermore, evidence indicates that preventing misalignment help reduce disorders impact neuro–immuno–metabolic disturbances in psychiatry. gut microbiota exhibits diurnal rhythmicity, as governed by meal timing, regulates host’s rhythms. Temporal regulation feeding has emerged promising chronotherapeutic strategy prevent and/or treatment illnesses, through modulation microbiota. Here, we provide an overview link between disruption illness. We summarize connection rhythms, supporting idea aid resynchronization disrupted describe microbiome rhythmicity its related factors, highlighting role timing. Lastly, emphasize necessity rationale further research develop effective safe dietary strategies based chrononutrition combat

Language: Английский

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The Relationship between Circadian Rhythm and Cancer Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5846 - 5846

Published: May 28, 2024

The circadian clock regulates biological cycles across species and is crucial for physiological activities biochemical reactions, including cancer onset development. interplay between the rhythm involves regulating cell division, DNA repair, immune function, hormonal balance, potential chronotherapy. This highlights importance of maintaining a healthy prevention treatment. article investigates complex relationship cancer, exploring how disruptions to internal may contribute tumorigenesis influence progression. Numerous databases are utilized conduct searches articles, such as NCBI, MEDLINE, Scopus. keywords used throughout academic archives “circadian rhythm”, ”cancer”, ”circadian clock”. Maintaining cycle prioritizing sleep habits minimizing disruptions, consistent schedules, reduced artificial light exposure, meal timing adjustments. Dysregulation gene can cause tumor growth, leading need regulate better treatment outcomes. components significantly impact cellular responses damage, influencing Understanding rhythm’s role in diseases their therapeutic targets essential treating preventing cancer. Disruptions promote abnormal development metastasis, potentially due system imbalances fluctuations.

Language: Английский

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The role of circadian clock in regulating cell functions: implications for diseases

MedComm, Journal Year: 2024, Volume and Issue: 5(3)

Published: March 1, 2024

Abstract The circadian clock system orchestrates daily behavioral and physiological rhythms, facilitating adaptation to environmental internal oscillations. Disruptions in rhythms have been linked increased susceptibility various diseases can exacerbate existing conditions. This review delves into the intricate regulation of diurnal gene expression cell function by clocks across diverse tissues. . Specifically, we explore rhythmicity expressions, behaviors, functions both immune non‐immune cells, elucidating regulatory effects mechanisms imposed clocks. A detailed discussion is centered on complex regulating key cellular signaling pathways. We further diseases, with a focus inflammatory cancers, systemic diseases. By highlighting intimate interplay between especially through clock‐controlled function, this contributes development novel disease intervention strategies. enhanced understanding holds significant promise for design targeted therapies that exploit improved treatment efficacy.

Language: Английский

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Programmable chronogenetic gene circuits for self-regulated circadian delivery of biologic drugs

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Abstract Cells of the body rely on circadian clock to orchestrate daily changes in physiology that impact both homeostatic and pathological conditions, such as inflammatory autoimmune disease rheumatoid arthritis (RA). In RA, high levels proinflammatory cytokines peak early morning hours, reflected by joint stiffness. Chronotherapy (or medicine) seeks delivery drugs at optimal times maximize their efficacy. However, chronotherapy remains a largely unexplored approach for modifying, antirheumatic treatment, particularly cell-based therapies. this study, we developed autonomous chronogenetic gene circuits produce biologic drug interleukin-1 receptor antagonist (IL-1Ra) with desired phase amplitude. We compared expression IL-1Ra from contained different promoter elements (E’-boxes, D-boxes, or RREs) ability respond challenges murine pre-differentiated induced pluripotent stem cells (PDiPSC) engineered cartilage pellets. confirmed each circuit reliably peaked distinct time over multiple days. Engineered generated significant amounts basis, which protected them dysregulation damage. These programmable have potential align an individual’s rhythm optimized, self-regulated delivery.

Language: Английский

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The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 8, 2023

Life expectancy is increasing throughout the world and coincides with a rise in non-communicable diseases (NCDs), especially for metabolic disease that includes diabetes mellitus (DM) neurodegenerative disorders. The debilitating effects of disorders influence entire body significantly affect nervous system impacting greater than one billion people disability peripheral as well cognitive loss, now seventh leading cause death worldwide. Metabolic disorders, such DM, neurologic remain significant challenge treatment care individuals since present therapies may limit symptoms but do not halt overall progression. These clinical challenges to address interplay between warrant innovative strategies can focus upon underlying mechanisms aging-related oxidative stress, cell senescence, death. Programmed pathways involve autophagy, apoptosis, ferroptosis, pyroptosis play critical role oversee processes include insulin resistance, β-cell function, mitochondrial integrity, reactive oxygen species release, inflammatory activation. silent mating type information regulation 2 homolog 1

Language: Английский

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Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock

npj Precision Oncology, Journal Year: 2024, Volume and Issue: 8(1)

Published: Feb. 20, 2024

Abstract Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major successes. This underlines necessity to understand glioblastoma biology on other levels and use these learnings for development new concepts. Mounting evidence in field circadian medicine points a tight interplay between disturbances system progression. The clock, an internal biological mechanism governing numerous physiological processes across 24-h cycle, also plays pivotal role regulationg key cellular functions, including DNA repair, cell cycle progression, apoptosis. These are integral tumour response therapy. Disruptions rhythms can influence growth, invasion, treatment patients. In this review, we explore robust association cancer hallmarks within context glioblastoma. We further discuss impact clock eight shown previously link molecular different cancers, summarize putative proteins rhythm chronotherapy By unravelling mechanisms behind intricate connections researchers pave way identification potential targets, innovative strategies personalized approaches. conclusion, review underscores significant advancement understanding future therapies glioblastoma, ultimately leading enhanced outcomes

Language: Английский

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The Metabolic Basis for Nervous System Dysfunction in Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease

Current Neurovascular Research, Journal Year: 2023, Volume and Issue: 20(3), P. 314 - 333

Published: July 25, 2023

Disorders of metabolism affect multiple systems throughout the body but may have greatest impact on both central and peripheral nervous systems. Currently available treatments behavior changes for disorders that include diabetes mellitus (DM) system diseases are limited cannot reverse disease burden. Greater access to healthcare a longer lifespan led an increased prevalence metabolic neurodegenerative disorders. In light these challenges, innovative studies into underlying pathways offer new treatment perspectives Alzheimer's Disease, Parkinson's Huntington's Disease. Metabolic intimately tied can lead debilitating outcomes, such as multi-nervous disease, susceptibility viral pathogens, long-term cognitive disability. Novel strategies robustly address involve careful consideration cellular metabolism, programmed cell death pathways, mechanistic target rapamycin (mTOR) its associated mTOR Complex 1 (mTORC1), 2 (mTORC2), AMP-activated protein kinase (AMPK), growth factor signaling, risk factors apolipoprotein E (APOE-ε4) gene. Yet, complex necessitate comprehensive understanding achieve clinical outcomes susceptibility, onset, progression.

Language: Английский

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