Global, regional, and national burden of early-onset gastric cancer

Cancer Biology and Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Aug. 7, 2024

The burden of gastric cancer (GC) across different age groups needs updating. We determined the GC global, regional, and national profiles changes in incidence for 3 sequential 5-year intervals from 2003 to 2017.

Language: Английский

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Residual gastric cancer with a mixed small cell neuroendocrine and keratinizing squamous cell carcinoma: A case report

World Journal of Clinical Oncology, Journal Year: 2025, Volume and Issue: 16(3)

Published: Jan. 20, 2025

BACKGROUND Despite advancements in early detection and treatment, the prognosis histological types for residual gastric cancer (GC) remains poor. CASE SUMMARY This case report presents a rare occurrence of GC featuring combination small cell neuroendocrine carcinoma (SCNEC) squamous (SCC) 60-year-old male patient. The patient, with history Billroth II gastrectomy duodenal ulcer bleeding, presented gastrointestinal bleeding. Preoperative computed tomography positron emission tomography-computed indicated adenocarcinoma tumor abdominal lymph node metastasis. patient underwent laparoscopic total dissection GC. Histological examination resected confirmed presence both SCNEC SCC. Postoperatively, adjuvant chemotherapy four times. Two years later, was found to occur esophageal performed bowel stoma radical esophagectomy. CONCLUSION In this report, we detail instance mixed SCC, emphasizing complexity diagnosis need ongoing research.

Language: Английский

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Cost-effectiveness of adding Helicobacter pylori screening to the National Gastric Cancer Screening Program in Korea (Preprint)

Published: Feb. 5, 2025

Helicobacter pylori (H. pylori) screening with eradication reduces gastric cancer incidence and mortality. This study evaluated the cost-effectiveness of incorporating H. into Korea's National Gastric Cancer Screening Program. A Markov model was developed to compare two strategies: (1) endoscopy every years starting at age 40 (conventional screening), (2) testing therapy 40, followed by continuous screening. The primary outcome is Incremental Cost-Utility Ratio (ICUR), calculated dividing incremental cost quality-adjusted life year (QALY) between strategies. Sensitivity analysis identified most influential variables for cost-effectiveness. parameter adding H.pylori current NCSP, which will be expressed as ICUR. Costs utility discounted an annual ra: determined that introducing Program a more cost-effective strategy reducing risk than conventional endoscopy-based program. te 4.5%. ICUR threshold set KRW 50 million, South Korea’s Gross Domestic Product (GDP) per capita. None

Language: Английский

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Isolation of daucosterol from Polygonum capitatum and its antitumor activity against gastric cancer BGC-823 cells

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 179, P. 1 - 10

Published: Feb. 8, 2025

Language: Английский

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Global, Regional, and National Burdens of Early Onset Gastric Cancer Aged 15-49 Years from 1990 to 2021 with Projections to 2035: A Population-Based Study

Published: Jan. 1, 2025

Language: Английский

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Spectrum of Upper Gastrointestinal Diseases in Patients Presenting with Dyspepsia—A First Report from Myanmar

JGH Open, Journal Year: 2025, Volume and Issue: 9(2)

Published: Feb. 1, 2025

ABSTRACT Background Dyspepsia is associated with a variety of benign and malignant gastrointestinal diseases. The aim the study was to evaluate spectrum upper endoscopic findings in patients presenting dyspepsia. Methods This retrospective on consecutive dyspepsia undergoing endoscopy at gastroenterology department Thingangyun General Hospital, University Medicine 2, Yangon, from January 1, 2017, December 31, 2019. Results In this study, 1650 were recruited retrospectively. Forty‐nine excluded due incomplete data entry. There 883 female (55%) out 1601 patients. mean age 50.5 ± 15.82 years. gastric/duodenal erosion (10.8%), erosive esophagitis (5.1%), duodenal ulcer (3.5%), gastric (4.4%), gastroesophageal varices (3.49%), esophageal cancer (0.8%), (5.3%); which early‐onset contributed for 17.6%. Miscellaneous diagnoses 4.2%, normal 62.5%. Significant diagnosed over 45 years age. Helicobacter pylori infection found 40.6% total population, 52% cancers, 50% ulcers, 51.2% 49.3% erosions. Conclusion dyspeptic are frequent our data. A considerable number under H. prevalent population. threshold 40–45 both males females could be reasonable use

Language: Английский

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Analysis of garlic intake on atrophic gastritis risk in different infectious states of Helicobacter pylori in a case-control study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 12, 2025

In this case-control study, the main risk factors for atrophic gastritis (AG) were comprehensively analyzed in a real-world environment to identify potential associated with garlic intake and its effects on AG. Design Upper gastrointestinal endoscopy pathological examination performed as part of gastric cancer screening health check-up program. The detailed characteristics both case group healthy control recorded analyzed. All participants fasted at least 4 h urea breath test13C-UBT) was all rest. Both univariate multivariate logistic regression analyses presented odds ratio (OR) 95% confidential interval (CI), additional subgroup analysis stratified by infectious state based presence, eradication or absence H. pylori. Setting Gansu Province China. Participants 10,035 people from China included. Among 7,058 participants, 4,712 (66.8%) had Garlic significant factor AG currently (infected state) previously (eradicated infected pylori (OR = 1.39, CI: 1.06–1.83; OR 1.16, CI 1.01–1.32). not significantly without pylori' s infection 1.14, 0.88–1.46). association between differed state. People eradicated states are higher intake. Diet may regulate pathogenic role intestinal flora.

Language: Английский

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Epidemiological and Pathophysiological Features of Gastric Cancer in Young Patients

Published: March 21, 2025

Introduction. Gastric cancer maintains a significant position among malignant neoplasms in terms of incidence rates and cancer-specific mortality, with higher prevalence geriatric patients. In recent years, there has been notable trend increasing oncological morbidity younger individuals. The aim the study is to identify epidemiological pathophysiological characteristics gastric young Materials methods. Thematic search scientific papers was carried out by keywords “early-onset cancer”, “young patients”, “gastric incidence”, “cancer-specific mortality”, “cancer patient survival”, “risk factors for tumor progression” cohort full-text publications presented electronic libraries eLibrary, PubMed, Scopus 2015–2024. Results. distribution patients age revealed that highest proportion cases both diagnosed deceased found under 50 years African countries, while lowest observed European countries. Malignant tumors individuals typically lack clinical symptoms, especially diffuse-type cancer. This may not be due involvement other organs but rather appearance signs upon primary dissemination, leading development complications. Risk include dietary disturbances, addictions, diseases esophagogastroduodenal zone hepatopancreatobiliary system, genetic mutations, microbial contamination, hormonal imbalances. A association between high frequency diffuse estrogen receptor expression women, particularly those an unfavorable prognosis. combination progression exacerbation dysbiosis gastroduodenal zone, as well lymphogenic metastasis, also highlighted. patients, locally advanced primarily disseminated neoplastic processes are dominant, degree malignancy. Discussion conclusion. promising avenue research involves refining pathogenic mechanisms carcinogenesis, relation estrogen-dependent proliferation epithelial cells, variability immune mediator signaling induction context pathomicrobiome, potential genuine reversals associated lifestyle changes.

Language: Английский

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Comparative Changes in Fecal Microbiome After Endoscopic Resection and Surgical Resection in Gastric Cancer Patients

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(4), P. 144 - 144

Published: April 4, 2025

Background/Objectives: Gastric cancer treatments can lead to significant alterations patients’ gastrointestinal microbiome. However, differences in microbial impacts between gastrectomy and endoscopic submucosal dissection (ESD) remain underexplored. This study investigates how these influence diversity composition patients with stage I gastric cancer. Methods: Patients pathologically confirmed were recruited from Chung-Ang University Hospital December 2016 2019. analyzed fecal samples 13 (ESD: n = 5; gastrectomy: 8) before after treatment using 16S rRNA gene sequencing. Microbial indices taxonomic compared, follow-up extending up two years. Results: In the total cohort, alpha significantly decreased post-treatment (p < 0.05), beta analysis showed distinct clustering pre- 0.05). At genus level, Bacteroides while Lactobacillus, Bifidobacterium, Blautia increases Comparative analyses revealed that ESD group, remained unchanged, although without notable changes major taxa. contrast, surgical resection resulted a reduction 0.05) increased abundances of Streptococcus abundance Conclusions: Surgical exerts effects on microbiome composition, has more limited impact. These findings underscore importance considering postoperative management.

Language: Английский

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Advances and applications of multiomics technologies in precision diagnosis and treatment for gastric cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189336 - 189336

Published: April 1, 2025

Language: Английский

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