Cerebellar organoids model cell type-specificFOXP2expression during human cerebellar development DOI Creative Commons
Elizabeth J. Apsley, Joey Riepsaame, Sally A. Cowley

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Abstract In this study, we demonstrate the potential of cerebellar organoids for studying features early human development. Forkhead box protein P2 (FOXP2) is a transcription factor associated with speech and language development that highly expressed in developing brain. However, little attention has been directed to study FOXP2 cerebellum. We used CRISPR gene editing iPSCs generate fluorescent FOXP2-reporter line. By combining transcriptomic analysis iPSC-derived published datasets, describe expression identify downstream targets Our results highlight Purkinje cells nuclei neurons, vulnerability these cell populations neurodevelopmental disorders. demonstrates power model developmental processes

Language: Английский

Cognitive-Affective Functions of the Cerebellum DOI Creative Commons
Stephanie Rudolph, Aleksandra Badura, Stefano Lutzu

et al.

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(45), P. 7554 - 7564

Published: Nov. 8, 2023

The cerebellum, traditionally associated with motor coordination and balance, also plays a crucial role in various aspects of higher-order function dysfunction. Emerging research has shed light on the cerebellum's broader contributions to cognitive, emotional, reward processes. influence autonomic further highlights its significance regulating motivational emotional states. Perturbations cerebellar development have been implicated neurodevelopmental disorders, including autism spectrum disorder attention deficit hyperactivity disorder. An increasing appreciation for neuropsychiatric symptoms that arise from dysfunction underscores importance elucidating circuit mechanisms underlie complex interactions between cerebellum other brain regions comprehensive understanding behavior. By briefly discussing new advances mapping affective, autonomic, social processing reviewing neuropathology beyond domain, this Mini-Symposium review aims provide broad perspective intersections limbic health disease.

Language: Английский

Citations

49
The interplay between oxidative stress and inflammation supports autistic-related behaviors in Cntnap2 knockout mice DOI Creative Commons
Luca Pangrazzi, Enrica Cerilli, Luigi Balasco

et al.

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Social and emotional learning in the cerebellum DOI
Frank Van Overwalle

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(12), P. 776 - 791

Published: Oct. 21, 2024

Language: Английский

Citations

7
Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice DOI Creative Commons
Meike E. van der Heijden

The Cerebellum, Journal Year: 2024, Volume and Issue: 23(5), P. 1754 - 1767

Published: May 23, 2024

Abstract Evidence from clinical and preclinical studies has shown that the cerebellum contributes to cognitive functions, including social behaviors. Now cerebellum’s role in a wider range of behaviors been confirmed, question arises whether via same mechanisms with which it modulates movements. This review seeks answer guides motor through identical pathways. It focuses on cerebellar cells, synapses, or genes are manipulated cell-type specific manner followed by testing effects These show both anatomically restricted cortex-wide manipulations can lead impairments without abnormal control, vice versa. suggest employs different cellular, synaptic, molecular pathways for Future warrant focus diverging wide neural functions.

Language: Английский

Citations

6
Unravelling the Cerebellar Involvement in Autism Spectrum Disorders: Insights into Genetic Mechanisms and Developmental Pathways DOI Creative Commons
Marika Guerra, Vanessa Medici, Gina La Sala

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(14), P. 1176 - 1176

Published: July 10, 2024

Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions characterized by deficits in social interaction and communication, as well repetitive behaviors. Although the etiology of ASD is multifactorial, with both genetic environmental factors contributing to its development, a strong basis widely recognized. Recent research has identified numerous mutations genomic rearrangements associated ASD-characterizing genes involved brain development. Alterations developmental programs particularly harmful during critical periods Notably, studies have indicated that disruptions occurring second trimester pregnancy affect cortical while disturbances perinatal early postnatal period cerebellar The defects must be viewed context role cerebellum cognitive processes, which now established. present review emphasizes complexity neuropathological mechanisms underlying aims provide insights into involvement disorder, focusing on recent advances molecular landscape governing development humans. Furthermore, we highlight when neurons ASD-associated may play cortico–cerebellar circuits. Finally, discuss improvements protocols for generating organoids recapitulate long maturation this organ. These models, if generated from patient-induced pluripotent stem cells (iPSC), could valuable approach elucidate contribution defective pathology inform diagnostic therapeutic strategies.

Language: Английский

Citations

5
Neuroanatomy of autism: what is the role of the cerebellum? DOI
Joan S. Baizer

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(13), P. 94 - 103

Published: May 1, 2024

Autism (or autism spectrum disorder) was initially defined as a psychiatric disorder, with the likely cause maternal behavior (the very destructive "refrigerator mother" theory). It took several decades for research into brain mechanisms to become established. Both neuropathological and imaging studies found differences in cerebellum most widely documented being decreased density of Purkinje cells cerebellar cortex. The popular interpretation these results is that neuropathology critical disorder. We challenge view by arguing if fewer are then any condition causes loss should also will review data on damage from lesions, tumors, syndromes (Joubert syndrome, Fragile X, tuberous sclerosis). Collectively, raise question whether really has role disorder now recognized genetically caused developmental A better understanding genes underlie development result show affect parallel structures do

Language: Английский

Citations

4
Enlightenment of ESCAP Autism Practice Guidelines for Autism Intervention Education in China DOI

朝阳 陶

Vocational Education, Journal Year: 2025, Volume and Issue: 14(02), P. 96 - 106

Published: Jan. 1, 2025

Language: Английский

Citations

0
Terra Incognita — Contributions of the Olivo-Cerebellar System to Autism Spectrum Disorder DOI

Pranav Shibu,

Daniel Ra,

Jemima Elise Robins

et al.

The Cerebellum, Journal Year: 2025, Volume and Issue: 24(4)

Published: May 2, 2025

Language: Английский

Citations

0
Cerebellar Alterations in Autism Spectrum Disorder: A Mini-Review DOI
Bianca Andrade Rodrigues, Josiane do Nascimento Silva, Elisa Mitiko Kawamoto

et al.

The Cerebellum, Journal Year: 2025, Volume and Issue: 24(2)

Published: Feb. 22, 2025

Language: Английский

Citations

0
A Gene-Expression Based Comparison of Murine and Human Inhibitory Interneurons in the Cerebellar Cortex and Nuclei DOI Creative Commons

Karl Schilling

The Cerebellum, Journal Year: 2025, Volume and Issue: 24(2)

Published: Feb. 28, 2025

Abstract Cerebellar information processing is critically shaped by several types of inhibitory interneurons forming various intra-cerebellar feed-forward and feed-back loops. Evidence gathered over the past decades has focused interest on a non-uniform set cortical distinct from “classical” Golgi, basket or stellate cells, summarily referred to as PLIs (for Purkinje cell layer interneurons). Similarly, cerebellar nuclear have gained increasing attention. Our understanding functions these cells still fragmentary. For humans, we lack functional data, even any dependable morphological classification for cells. Here, I used publicly available single based gene expression data compare cortex neurons humans mice. Integration revealed transcriptomic similarities between subsets suggest known characteristics may be helpful devise strategies further characterization interneurons. Comparison human murine indicate that strongly differ genes characterize in This limits their utility identify classify PLIs, leaves question open number non-Golgi resident granule layers humans.

Language: Английский

Citations

0