Hepatoprotective Effects of Flavonoids against Benzo[a]Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(2), P. 180 - 180
Published: Jan. 31, 2024
Benzo[a]pyrene
(B[a]P),
a
highly
carcinogenic
polycyclic
aromatic
hydrocarbon
primarily
formed
during
incomplete
organic
matter
combustion,
undergoes
series
of
hepatic
metabolic
reactions
once
absorbed
into
the
body.
B[a]P
contributes
to
liver
damage,
ranging
from
molecular
DNA
damage
onset
and
progression
various
diseases,
including
cancer.
Specifically,
induces
oxidative
stress
via
reactive
oxygen
species
generation
within
cells.
Consequently,
more
research
has
focused
on
exploring
underlying
mechanisms
B[a]P-induced
potential
strategies
counter
its
toxicity.
Flavonoids,
natural
compounds
abundant
in
plants
renowned
for
their
antioxidant
properties,
possess
ability
neutralize
adverse
effects
free
radicals
effectively.
Although
extensive
investigated
flavonoids,
limited
delved
regulating
metabolism
alleviate
stress.
This
review
aims
consolidate
current
knowledge
examines
role
flavonoids
mitigating
Language: Английский
Kaempferol: A Review of Current Evidence of Its Antiviral Potential
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(22), P. 16299 - 16299
Published: Nov. 14, 2023
Kaempferol
and
its
derivatives
are
flavonoids
found
in
various
plants,
a
considerable
number
of
these
have
been
used
medical
applications
worldwide.
compounds
well-known
antioxidant,
anti-inflammatory
antimicrobial
properties
among
other
health
benefits.
However,
the
antiviral
kaempferol
notable,
there
is
significant
experimental
studies
on
this
topic.
were
effective
against
DNA
viruses
such
as
hepatitis
B
virus,
alphaherpesvirinae
family,
African
swine
fever
pseudorabies
virus;
they
also
RNA
viruses,
namely
feline
SARS
coronavirus,
dengue
Japanese
encephalitis
influenza
enterovirus
71,
poliovirus,
respiratory
syncytial
human
immunodeficiency
calicivirus,
chikungunya
virus.
On
hand,
no
effectiveness
murine
norovirus
A
virus
could
be
determined.
The
action
mechanisms
various,
inhibition
viral
polymerases
attachment
entry
into
host
cells.
Future
research
should
focused
further
elucidating
from
different
plants
assessing
their
potential
use
to
complement
drugs.
Language: Английский
Roles of the Caspase-11 Non-Canonical Inflammasome in Rheumatic Diseases
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2091 - 2091
Published: Feb. 8, 2024
Inflammasomes
are
intracellular
multiprotein
complexes
that
activate
inflammatory
signaling
pathways.
comprise
two
major
classes:
canonical
inflammasomes,
which
were
discovered
first
and
activated
in
response
to
a
variety
of
pathogen-associated
molecular
patterns
(PAMPs)
danger-associated
(DAMPs),
non-canonical
recently
only
lipopolysaccharide
(LPS).
Although
larger
number
studies
have
successfully
demonstrated
particularly
the
NLRP3
inflammasome,
play
roles
various
rheumatic
diseases,
including
rheumatoid
arthritis
(RA),
infectious
(IR),
gouty
(GA),
osteoarthritis
(OA),
systemic
lupus
erythematosus
(SLE),
psoriatic
(PA),
ankylosing
spondylitis
(AS),
Sjögren’s
syndrome
(SjS),
regulatory
such
as
mouse
caspase-11
human
caspase-4
these
diseases
still
largely
unknown.
Interestingly,
an
increasing
reported
possible
for
inflammasomes
pathogenesis
models
disease.
This
review
comprehensively
summarizes
discusses
recent
emerging
demonstrating
focusing
on
progression
types
provides
new
insights
into
strategies
developing
potential
therapeutics
prevent
treat
well
associated
by
targeting
inflammasomes.
Language: Английский
Regulatory Roles of Flavonoids in Caspase-11 Non-canonical Inflammasome-mediated Inflammatory Responses and Diseases
Published: June 9, 2023
Inflammasomes
are
multiprotein
complexes
that
activate
inflammatory
responses
by
inducing
pyroptosis
and
secretion
of
pro-inflammatory
cytokines.
Along
with
many
previous
studies
on
diseases
induced
canonical
inflammasomes,
an
increasing
number
have
demonstrated
non-canonical
such
as
mouse
caspase-11
human
caspase-4
emerging
key
players
in
various
diseases.
Flavonoids
natural
bioactive
compounds
found
plants,
fruits,
vegetables,
teas
pharmacological
properties
a
wide
range
Many
successfully
flavonoids
play
anti-inflammatory
role
ameliorate
inhibiting
inflammasomes.
Others
the
roles
diseases,
new
mechanism
which
inhibit
This
review
discusses
recent
investigated
inflammasomes
further
provides
insight
into
developing
flavonoid-based
therapeutics
potential
nutraceuticals
against
Language: Английский
Quercetin Ameliorates Acute Lethal Sepsis in Mice by Inhibiting Caspase-11 Noncanonical Inflammasome in Macrophages
Molecules,
Journal Year:
2024,
Volume and Issue:
29(24), P. 5900 - 5900
Published: Dec. 13, 2024
Quercetin
is
a
natural
polyphenolic
flavonoid
widely
found
in
plants,
fruits,
and
vegetables,
has
been
reported
to
play
pharmacological
roles
numerous
pathogenic
conditions.
The
anti-inflammatory
effects
of
quercetin
various
inflammatory
conditions
diseases
have
well-documented.
However,
its
regulatory
role
noncanonical
inflammasome
activation
not
yet
demonstrated.
This
study
investigated
the
caspase-11
inflammasome-activated
responses
macrophages
mouse
model
acute
lethal
sepsis.
protected
J774A.1
from
lipopolysaccharide
(LPS)-induced
cell
death
inflammasome-induced
pyroptosis.
It
significantly
decreased
production
mRNA
expression
pro-inflammatory
cytokines,
such
as
interleukin
(IL)-1β,
IL-18,
IL-6,
but
tumor
necrosis
factor
(TNF)-α,
molecules,
nitric
oxide
(NO)
inducible
NO
synthase
cells.
Mechanistically,
strongly
suppressed
autoproteolysis
secretion
proteolysis
gasdermin
D
did
inhibit
direct
binding
LPS.
In
vivo,
revealed
that
increased
survival
rate
mice
with
sepsis
serum
levels
cytokines
without
causing
significant
toxicity.
conclusion,
this
highlights
quercetin-mediated
action
through
novel
mechanism
targets
macrophages,
suggesting
promising
agent
medicine.
Language: Английский